Aclarubicin

DB11617

small molecule investigational

Deskripsi

Struktur Molekul 2D

Berat 811.878
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

41 Data
Trastuzumab The risk or severity of cardiotoxicity can be increased when Trastuzumab is combined with Aclarubicin.
Margetuximab The risk or severity of cardiotoxicity can be increased when Margetuximab is combined with Aclarubicin.
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Aclarubicin.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Aclarubicin.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Aclarubicin.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Aclarubicin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Aclarubicin.
Ambroxol The risk or severity of methemoglobinemia can be increased when Aclarubicin is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Aclarubicin is combined with Etrasimod.

Target Protein

DNA topoisomerase 2-alpha TOP2A
DNA topoisomerase 2-beta TOP2B

Referensi & Sumber

Artikel (PubMed)
  • PMID: 1655244
    Jensen PB, Jensen PS, Demant EJ, Friche E, Sorensen BS, Sehested M, Wassermann K, Vindelov L, Westergaard O, Hansen HH: Antagonistic effect of aclarubicin on daunorubicin-induced cytotoxicity in human small cell lung cancer cells: relationship to DNA integrity and topoisomerase II. Cancer Res. 1991 Oct 1;51(19):5093-9.
  • PMID: 23715267
    Pang B, Qiao X, Janssen L, Velds A, Groothuis T, Kerkhoven R, Nieuwland M, Ovaa H, Rottenberg S, van Tellingen O, Janssen J, Huijgens P, Zwart W, Neefjes J: Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin. Nat Commun. 2013;4:1908. doi: 10.1038/ncomms2921.
  • PMID: 25961671
    Pang B, de Jong J, Qiao X, Wessels LF, Neefjes J: Chemical profiling of the genome with anti-cancer drugs defines target specificities. Nat Chem Biol. 2015 Jul;11(7):472-80. doi: 10.1038/nchembio.1811. Epub 2015 May 11.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul