The toxic effects of normethadone are similar to those of other opioids. It can produce respiratory depression, depression of central nervous system function, and constipation FDA Label.
Normethadone is used as an opioid antitussive in combination with DB11610. It is marketed in Canada by Valeant under the tradename Cophylac.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Buprenorphine | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine. |
| Doxylamine | Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Dronabinol | Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Droperidol | Droperidol may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Hydrocodone | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone. |
| Hydroxyzine | Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Magnesium sulfate | The therapeutic efficacy of Normethadone can be increased when used in combination with Magnesium sulfate. |
| Methotrimeprazine | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine. |
| Metyrosine | Normethadone may increase the sedative activities of Metyrosine. |
| Minocycline | Minocycline may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Nabilone | Nabilone may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Orphenadrine | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine. |
| Paraldehyde | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde. |
| Perampanel | Perampanel may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Pramipexole | Normethadone may increase the sedative activities of Pramipexole. |
| Ropinirole | Normethadone may increase the sedative activities of Ropinirole. |
| Rotigotine | Normethadone may increase the sedative activities of Rotigotine. |
| Rufinamide | The risk or severity of adverse effects can be increased when Rufinamide is combined with Normethadone. |
| Sodium oxybate | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate. |
| Suvorexant | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant. |
| Tapentadol | Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Thalidomide | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide. |
| Zolpidem | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem. |
| Alvimopan | The risk or severity of adverse effects can be increased when Normethadone is combined with Alvimopan. |
| Desmopressin | The risk or severity of hyponatremia can be increased when Normethadone is combined with Desmopressin. |
| Morphine | The risk or severity of adverse effects can be increased when Morphine is combined with Normethadone. |
| Codeine | The risk or severity of adverse effects can be increased when Codeine is combined with Normethadone. |
| Hydromorphone | The risk or severity of adverse effects can be increased when Hydromorphone is combined with Normethadone. |
| Meperidine | The risk or severity of adverse effects can be increased when Meperidine is combined with Normethadone. |
| Oxycodone | The risk or severity of adverse effects can be increased when Oxycodone is combined with Normethadone. |
| Dextropropoxyphene | The risk or severity of adverse effects can be increased when Dextropropoxyphene is combined with Normethadone. |
| Naltrexone | The therapeutic efficacy of Normethadone can be decreased when used in combination with Naltrexone. |
| Sufentanil | The risk or severity of adverse effects can be increased when Sufentanil is combined with Normethadone. |
| Alfentanil | The risk or severity of adverse effects can be increased when Alfentanil is combined with Normethadone. |
| Fentanyl | The risk or severity of adverse effects can be increased when Fentanyl is combined with Normethadone. |
| Levorphanol | The risk or severity of adverse effects can be increased when Levorphanol is combined with Normethadone. |
| Remifentanil | The risk or severity of adverse effects can be increased when Remifentanil is combined with Normethadone. |
| Diphenoxylate | The risk or severity of adverse effects can be increased when Diphenoxylate is combined with Normethadone. |
| Oxymorphone | The risk or severity of adverse effects can be increased when Oxymorphone is combined with Normethadone. |
| Dezocine | The risk or severity of adverse effects can be increased when Dezocine is combined with Normethadone. |
| Methadyl acetate | The risk or severity of adverse effects can be increased when Methadyl acetate is combined with Normethadone. |
| Dihydroetorphine | The risk or severity of adverse effects can be increased when Dihydroetorphine is combined with Normethadone. |
| Diamorphine | The risk or severity of adverse effects can be increased when Diamorphine is combined with Normethadone. |
| Bezitramide | The risk or severity of adverse effects can be increased when Bezitramide is combined with Normethadone. |
| Ethylmorphine | The risk or severity of adverse effects can be increased when Ethylmorphine is combined with Normethadone. |
| Etorphine | The risk or severity of adverse effects can be increased when Etorphine is combined with Normethadone. |
| Dextromoramide | The risk or severity of adverse effects can be increased when Dextromoramide is combined with Normethadone. |
| Desomorphine | The risk or severity of adverse effects can be increased when Desomorphine is combined with Normethadone. |
| Carfentanil | The risk or severity of adverse effects can be increased when Carfentanil is combined with Normethadone. |
| Dihydrocodeine | The risk or severity of adverse effects can be increased when Dihydrocodeine is combined with Normethadone. |
| Alphacetylmethadol | The risk or severity of adverse effects can be increased when Alphacetylmethadol is combined with Normethadone. |
| Dihydromorphine | The risk or severity of adverse effects can be increased when Dihydromorphine is combined with Normethadone. |
| Ketobemidone | The risk or severity of adverse effects can be increased when Ketobemidone is combined with Normethadone. |
| DPDPE | The risk or severity of adverse effects can be increased when DPDPE is combined with Normethadone. |
| Lofentanil | The risk or severity of adverse effects can be increased when Lofentanil is combined with Normethadone. |
| Opium | The risk or severity of adverse effects can be increased when Opium is combined with Normethadone. |
| Piritramide | The risk or severity of adverse effects can be increased when Normethadone is combined with Piritramide. |
| Alphaprodine | The risk or severity of adverse effects can be increased when Normethadone is combined with Alphaprodine. |
| Nicomorphine | The risk or severity of adverse effects can be increased when Normethadone is combined with Nicomorphine. |
| Meptazinol | The therapeutic efficacy of Normethadone can be decreased when used in combination with Meptazinol. |
| Phenoperidine | The risk or severity of adverse effects can be increased when Normethadone is combined with Phenoperidine. |
| Phenazocine | The risk or severity of adverse effects can be increased when Normethadone is combined with Phenazocine. |
| Tilidine | The risk or severity of adverse effects can be increased when Normethadone is combined with Tilidine. |
| Carfentanil, C-11 | The risk or severity of adverse effects can be increased when Normethadone is combined with Carfentanil, C-11. |
| Naloxegol | The risk or severity of adverse effects can be increased when Naloxegol is combined with Normethadone. |
| Benzhydrocodone | The risk or severity of adverse effects can be increased when Normethadone is combined with Benzhydrocodone. |
| Pegvisomant | The therapeutic efficacy of Pegvisomant can be decreased when used in combination with Normethadone. |
| Succinylcholine | The risk or severity of bradycardia can be increased when Succinylcholine is combined with Normethadone. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Normethadone. |
| Linezolid | The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Normethadone. |
| Mirtazapine | Normethadone may increase the serotonergic activities of Mirtazapine. |
| Fluvoxamine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Fluvoxamine. |
| Citalopram | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Citalopram. |
| Duloxetine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Duloxetine. |
| Paroxetine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Paroxetine. |
| Sertraline | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Sertraline. |
| Sibutramine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Sibutramine. |
| Nefazodone | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Nefazodone. |
| Zimelidine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Zimelidine. |
| Dapoxetine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Dapoxetine. |
| Milnacipran | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Milnacipran. |
| Desvenlafaxine | The risk or severity of serotonin syndrome can be increased when Desvenlafaxine is combined with Normethadone. |
| Seproxetine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Seproxetine. |
| Levomilnacipran | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Levomilnacipran. |
| Indalpine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Indalpine. |
| Ritanserin | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Ritanserin. |
| Alaproclate | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Alaproclate. |
| Ethanol | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Ethanol. |
| Azelastine | Normethadone may increase the central nervous system depressant (CNS depressant) activities of Azelastine. |
| Brimonidine | Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Normethadone. |
| Phentermine | Phentermine may increase the analgesic activities of Normethadone. |
| Pseudoephedrine | Pseudoephedrine may increase the analgesic activities of Normethadone. |
| Benzphetamine | Benzphetamine may increase the analgesic activities of Normethadone. |
| Diethylpropion | Diethylpropion may increase the analgesic activities of Normethadone. |
| Lisdexamfetamine | The risk or severity of serotonin syndrome can be increased when Normethadone is combined with Lisdexamfetamine. |
| Mephentermine | Mephentermine may increase the analgesic activities of Normethadone. |
| MMDA | MMDA may increase the analgesic activities of Normethadone. |
| Midomafetamine | Midomafetamine may increase the analgesic activities of Normethadone. |
| 2,5-Dimethoxy-4-ethylamphetamine | 2,5-Dimethoxy-4-ethylamphetamine may increase the analgesic activities of Normethadone. |
| 4-Bromo-2,5-dimethoxyamphetamine | 4-Bromo-2,5-dimethoxyamphetamine may increase the analgesic activities of Normethadone. |