Peringatan Keamanan

May cause chemical pneumonitis in case of inhalation and skin irritation. Animal data suggests potential alteration in female fertility.

Hydroxyethyl cellulose

DB11602

small molecule approved

Deskripsi

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties. It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature. It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.

Struktur Molekul 2D

Berat 806.937

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi -

Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 25735667
Mianehrow H, Moghadam MH, Sharif F, Mazinani S: Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application. Int J Pharm. 2015 Apr 30;484(1-2):276-82. doi: 10.1016/j.ijpharm.2015.02.069. Epub 2015 Feb 28.
PMID: 16081080
Wang J, Somasundaran P: Mechanisms of ethyl(hydroxyethyl) cellulose-solid interaction: influence of hydrophobic modification. J Colloid Interface Sci. 2006 Jan 15;293(2):322-32. Epub 2005 Aug 2.
PMID: 11438427
Giandalia G, De Caro V, Cordone L, Giannola LI: Trehalose-hydroxyethylcellulose microspheres containing vancomycin for topical drug delivery. Eur J Pharm Biopharm. 2001 Jul;52(1):83-9.
PMID: 2612782
Durand-Cavagna G, Delort P, Duprat P, Bailly Y, Plazonnet B, Gordon LR: Corneal toxicity studies in rabbits and dogs with hydroxyethyl cellulose and benzalkonium chloride. Fundam Appl Toxicol. 1989 Oct;13(3):500-8.
PMID: 24772038
Baranowski P, Karolewicz B, Gajda M, Pluta J: Ophthalmic drug dosage forms: characterisation and research methods. ScientificWorldJournal. 2014 Mar 18;2014:861904. doi: 10.1155/2014/861904. eCollection 2014.
PMID: 24363715
Mortazavi SA, Jaffariazar Z, Damercheli E: Formulation and In-Vitro Evaluation of Ocular Ciprofloxacin-Containing Minitablets Prepared with Different Combinations of Carbopol 974P and Various Cellulose Derivatives. Iran J Pharm Res. 2010 Spring;9(2):107-14.

Link

Cellosize product information

Contoh Produk & Brand

Produk: 15 • International brands: 1

Produk

AnubisMed

Liquid • - • Topical • US • OTC
AOPAR Water Based Personal Lubricant

Lotion • 0.381 g/30mL • Rectal; Vaginal • US • OTC
ExEm Foam

Kit • - • Intrauterine • US • Approved
Goojin Bio Serum

Liquid • - • Topical • US • OTC
Gujin Bio Serum

Liquid • - • Topical • US • OTC
Inner Cell Serum- Serum

Emulsion • - • Topical • US • OTC
Jenacell Supercell Serum

Liquid • - • Topical • US • OTC
Odan-atropine

Solution / drops • - • Ophthalmic • Canada • Generic • Approved

Menampilkan 8 dari 15 produk.

International Brands

Cellosize — The DOW Chemical Company

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.