Peringatan Keamanan

Dermal and oral LD50 in rat is > 2000 mg/kg MSDS.

Aluminum chlorohydrate

DB11573

small molecule approved

Deskripsi

Aluminum chlorohydrate is a group of water-soluble aluminum complexes with the general formula AlnCl(3n-m)(OH)m. It is included up to 25% in over-the-counter hygiene products as an active antiperspirant agent. The primary site of action of aluminum chlorohydrate is at the level of the stratum corneum layer, which is relatively near the skin surface A27159. It is also used as a coagulant in the water purification process.

Struktur Molekul 2D

Berat 192.46
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic information available.
Volume Distribusi No pharmacokinetic information available.
Klirens (Clearance) No pharmacokinetic information available.

Absorpsi

Penetration of aluminum chlorohydrate following dermal application is minimal, with the rate being around 0.01% and up to 0.06% in pre-damaged skin A32407. In a preliminary study, dermally applied aluminium chlorohydrate displayed 0.012% of the applied aluminium being absorbed through the skin, which accounts for 4 mcg of aluminum following a single dermal application A32406. This is about 2.5% of the aluminium typically absorbed by the gut from food over the same time period A32406.

Metabolisme

No pharmacokinetic information available.

Rute Eliminasi

No pharmacokinetic information available.

Interaksi Obat

22 Data
Ursodeoxycholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Ursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Glycochenodeoxycholic Acid Aluminum chlorohydrate can cause a decrease in the absorption of Glycochenodeoxycholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cholic Acid Aluminum chlorohydrate can cause a decrease in the absorption of Cholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Glycocholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Glycocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deoxycholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Deoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Taurocholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Taurocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Obeticholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Obeticholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Chenodeoxycholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Chenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Taurochenodeoxycholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Taurochenodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tauroursodeoxycholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Tauroursodeoxycholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Bamet-UD2 Aluminum chlorohydrate can cause a decrease in the absorption of Bamet-UD2 resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dehydrocholic acid Aluminum chlorohydrate can cause a decrease in the absorption of Dehydrocholic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Hyodeoxycholic Acid Aluminum chlorohydrate can cause a decrease in the absorption of Hyodeoxycholic Acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Aluminum chlorohydrate.
Halofantrine Aluminum chlorohydrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
cis-Diamminechlorocholylglycinateplatinum(II) The serum concentration of cis-Diamminechlorocholylglycinateplatinum(II) can be decreased when it is combined with Aluminum chlorohydrate.
Aramchol The serum concentration of Aramchol can be decreased when it is combined with Aluminum chlorohydrate.
Ox bile extract The serum concentration of Ox bile extract can be decreased when it is combined with Aluminum chlorohydrate.
Technetium Tc-99m oxidronate The serum concentration of Technetium Tc-99m oxidronate can be increased when it is combined with Aluminum chlorohydrate.
Phenytoin Aluminum chlorohydrate can cause a decrease in the absorption of Phenytoin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Roxadustat Aluminum chlorohydrate can cause a decrease in the absorption of Roxadustat resulting in a reduced serum concentration and potentially a decrease in efficacy.
Vadadustat The serum concentration of Vadadustat can be decreased when it is combined with Aluminum chlorohydrate.

Referensi & Sumber

Artikel (PubMed)
  • PMID: -
    Quatrale RP, Coble DW, Stoner KL, Felger CB: The mechanism of antiperspirant action by aluminum salts. II. Histological observations of human eccrine sweat glands inhibited by aluminum chlorohydrate Journal of the Society of Cosmetic Chemists. 1981 Jan 1;32(3):107-136.
  • PMID: 11267710
    Flarend R, Bin T, Elmore D, Hem SL: A preliminary study of the dermal absorption of aluminium from antiperspirants using aluminium-26. Food Chem Toxicol. 2001 Feb;39(2):163-8.
  • PMID: 29034866
    Klotz K, Weistenhofer W, Neff F, Hartwig A, van Thriel C, Drexler H: The Health Effects of Aluminum Exposure. Dtsch Arztebl Int. 2017 Sep 29;114(39):653-659. doi: 10.3238/arztebl.2017.0653.
  • PMID: 28485735
    Bretagne A, Cotot F, Arnaud-Roux M, Sztucki M, Cabane B, Galey JB: The mechanism of eccrine sweat pore plugging by aluminium salts using microfluidics combined with small angle X-ray scattering. Soft Matter. 2017 May 24;13(20):3812-3821. doi: 10.1039/c6sm02510b.

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