Peringatan Keamanan

No cases of overdose have been reported at this time FDA Label. The LD50 value for the mouse model is calculated to be approximately 3 gm/kg MSDS.

Human thrombin

DB11571

biotech approved

Deskripsi

Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This transformation mimics the final coagulation cascade step which involves the clotting mass that adheres to the wound surface and achieves hemostasis and sealing of open tissues.

In particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin is a human coagulation protein produced via recombinant DNA technology from a genetically modified Chinese hamster ovary cell line FDA Label. Furthermore, human thrombin is manufactured by chromatographic purification of prothrombin from cryo-poor plasma followed by activation with calcium chloride FDA Label.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Due to the nature of the product, which is intended for topical application to the surface of the tissue at the surgical site, pharmacokinetic studies were not conducted [FDA Label].
Volume Distribusi Due to the nature of the product, which is intended for topical application to the surface of the tissue at the surgical site, pharmacokinetic studies were not conducted [FDA Label]. Precisely because human thrombin is applied only topically, systemic exposure or distribution to other organs and tissues is not expected [A32427].
Klirens (Clearance) Due to the nature of the product, which is intended for topical application to the surface of the tissue at the surgical site, pharmacokinetic studies were not conducted [FDA Label]. Regardless, commercial human thrombin, like endogenous thrombin, is generally rapidly neutralized by naturally circulating plasma inhibitors limiting its duration of action and preventing the active form from diffusing into the general circulation [L2079].

Absorpsi

Due to the nature of the product, which is intended for topical application to the surface of the tissue at the surgical site, pharmacokinetic studies were not conducted FDA Label. Particularly because the agent is topical, systemic absorption is expected to be small A32427.

Metabolisme

Due to the nature of the product, which is intended for topical application to the surface of the tissue at the surgical site, pharmacokinetic studies were not conducted FDA Label. Nevertheless, commercial human thrombin products are expected to be metabolized in the same way as endogenous thrombin is. Endogenous thrombin does not circulate in the blood as a free, active molecule for very long L2079. After performing its function it is rapidly inactivated after formation of complexes with various circulating endogenous plasma inhibitors (like antithrombin III) L2079. This rapid inactivation prevents the active agent from diffusing into the general circulation. The complexes formed are then generally cleared and eliminated by the liver L2079.

Rute Eliminasi

Due to the nature of the product, which is intended for topical application to the surface of the tissue at the surgical site, pharmacokinetic studies were not conducted FDA Label. Nevertheless, commercial human thrombin products are expected to act in much the same way as endogenous thrombin does. Natural bodily thrombin is cleared by two primary separate pathways: (1) through rapid formation of thrombin inhibitor complexes, which are recognized by hepatic receptors and degraded, and (2) via direct binding to thrombomodulin on the endothelium, followed by internalization and degradation L2079. Specific thrombin inhibitors include ATIII, alpha-2M and heparin cofactor II L2079.

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

Coagulation factor V F5
Coagulation factor VIII F8
Coagulation factor XI F11
Coagulation factor XIII A chain F13A1
Coagulation factor XIII B chain F13B
Fibrinogen alpha chain FGA
Fibrinogen beta chain FGB
Fibrinogen gamma chain FGG

Referensi & Sumber

Artikel (PubMed)
  • PMID: 24625330
    Mandell SP, Gibran NS: Fibrin sealants: surgical hemostat, sealant and adhesive. Expert Opin Biol Ther. 2014 Jun;14(6):821-30. doi: 10.1517/14712598.2014.897323. Epub 2014 Mar 13.
  • PMID: 17635715
    Crawley JT, Zanardelli S, Chion CK, Lane DA: The central role of thrombin in hemostasis. J Thromb Haemost. 2007 Jul;5 Suppl 1:95-101. doi: 10.1111/j.1538-7836.2007.02500.x.

Contoh Produk & Brand

Produk: 73 • International brands: 0
Produk
  • Artiss
    Kit • - • Topical • US • Approved
  • Artiss
    Solution • - • Topical • Canada • Approved
  • ARTISS Fibrin Sealant
    Solution • - • Topical • US • Approved
  • ARTISS Fibrin Sealant
    Solution • - • Topical • US • Approved
  • ARTISS Fibrin Sealant
    Solution • - • Topical • US • Approved
  • ARTISS Fibrin Sealant
    Solution • - • Topical • US • Approved
  • ARTISS Frozen
    Solution • - • Topical • US • Approved
  • Evarrest
    Patch • - • Topical • US • Approved
Menampilkan 8 dari 73 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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