Lesinurad is an oral uric acid transporter 1 (URAT1) inhibitor indicated for the treatment of hyperuricemia associated with gout. It reduces serum uric acid concentration through the inhibition of URAT1, an enzyme responsible for reuptake of uric acid from the renal tubule, and OAT4, another uric acid transporter associated with diuretic-induced hyperuricemia.
Marketed as the product Zurampic, it is indicated for use in combination with a xanthine oxidase inhibitor for the treatment of hyperuricemia associated with gout in
patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone. In August 2017, a combination oral therapy consisting of lesinurad and DB00437 was FDA-approved under the brand name Duzallo indicated for the treatment of gout-related hyperuricemia in patients with uncontrolled gout.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Nitrofurantoin | The serum concentration of Nitrofurantoin can be increased when it is combined with Lesinurad. |
| Pegloticase | The risk or severity of adverse effects can be increased when Lesinurad is combined with Pegloticase. |
| Fluvoxamine | The metabolism of Lesinurad can be decreased when combined with Fluvoxamine. |
| Troglitazone | The metabolism of Lesinurad can be decreased when combined with Troglitazone. |
| Fluoxetine | The metabolism of Lesinurad can be decreased when combined with Fluoxetine. |
| Nabilone | The metabolism of Lesinurad can be decreased when combined with Nabilone. |
| Efavirenz | The metabolism of Lesinurad can be decreased when combined with Efavirenz. |
| Mifepristone | The metabolism of Lesinurad can be decreased when combined with Mifepristone. |
| Felbamate | The metabolism of Lesinurad can be decreased when combined with Felbamate. |
| Sulfinpyrazone | The metabolism of Lesinurad can be decreased when combined with Sulfinpyrazone. |
| Iproniazid | The metabolism of Lesinurad can be decreased when combined with Iproniazid. |
| Medical Cannabis | The metabolism of Lesinurad can be decreased when combined with Medical Cannabis. |
| Imatinib | The metabolism of Lesinurad can be decreased when combined with Imatinib. |
| Valproic acid | The metabolism of Lesinurad can be decreased when combined with Valproic acid. |
| Fluconazole | The metabolism of Lesinurad can be decreased when combined with Fluconazole. |
| Floxuridine | The metabolism of Lesinurad can be decreased when combined with Floxuridine. |
| Nicardipine | The metabolism of Lesinurad can be decreased when combined with Nicardipine. |
| Delavirdine | The metabolism of Lesinurad can be decreased when combined with Delavirdine. |
| Miconazole | The metabolism of Lesinurad can be decreased when combined with Miconazole. |
| Gemfibrozil | The metabolism of Lesinurad can be decreased when combined with Gemfibrozil. |
| Sulfaphenazole | The metabolism of Lesinurad can be decreased when combined with Sulfaphenazole. |
| Icosapent | Icosapent may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefotiam | Cefotiam may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Mesalazine | Mesalazine may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefmenoxime | Cefmenoxime may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefmetazole | Cefmetazole may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Pamidronic acid | Pamidronic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Tenofovir disoproxil | Tenofovir disoproxil may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Indomethacin | Indomethacin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cidofovir | Cidofovir may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefpiramide | Cefpiramide may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ceftazidime | Ceftazidime may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Loracarbef | Loracarbef may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefalotin | Cefalotin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Nabumetone | Nabumetone may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ketorolac | Ketorolac may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Tenoxicam | Tenoxicam may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Celecoxib | Celecoxib may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefotaxime | Cefotaxime may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Tolmetin | Tolmetin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Foscarnet | Foscarnet may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Rofecoxib | Rofecoxib may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Piroxicam | Piroxicam may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Fenoprofen | Fenoprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Valaciclovir | Valaciclovir may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Valdecoxib | Valdecoxib may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Diclofenac | Diclofenac may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Sulindac | Sulindac may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Bacitracin | Bacitracin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Amphotericin B | Amphotericin B may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cephaloglycin | Cephaloglycin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Flurbiprofen | Flurbiprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Adefovir dipivoxil | Adefovir dipivoxil may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Pentamidine | Pentamidine may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Etodolac | Etodolac may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Mefenamic acid | Mefenamic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Acyclovir | Acyclovir may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Naproxen | Naproxen may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Sulfasalazine | Sulfasalazine may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Meloxicam | Meloxicam may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Carprofen | Carprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefaclor | Cefaclor may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Diflunisal | Diflunisal may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ceforanide | Ceforanide may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Salicylic acid | Salicylic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Meclofenamic acid | Meclofenamic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Carboplatin | Carboplatin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Oxaprozin | Oxaprozin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ketoprofen | Ketoprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Balsalazide | Balsalazide may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ibuprofen | Ibuprofen may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefditoren | Cefditoren may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Colistimethate | Colistimethate may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefuroxime | Cefuroxime may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefapirin | Cefapirin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefadroxil | Cefadroxil may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefprozil | Cefprozil may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ceftriaxone | Ceftriaxone may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Olsalazine | Olsalazine may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Lumiracoxib | Lumiracoxib may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefamandole | Cefamandole may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefazolin | Cefazolin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefonicid | Cefonicid may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefoperazone | Cefoperazone may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefotetan | Cefotetan may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefoxitin | Cefoxitin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ceftizoxime | Ceftizoxime may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefradine | Cefradine may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Magnesium salicylate | Magnesium salicylate may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Salsalate | Salsalate may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Choline magnesium trisalicylate | Choline magnesium trisalicylate may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefepime | Cefepime may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefacetrile | Cefacetrile may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Ceftibuten | Ceftibuten may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Cefpodoxime | Cefpodoxime may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Antrafenine | Antrafenine may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Aminophenazone | Aminophenazone may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Antipyrine | Antipyrine may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Tiaprofenic acid | Tiaprofenic acid may decrease the excretion rate of Lesinurad which could result in a higher serum level. |
| Hydrolyzed Cephalothin | Hydrolyzed Cephalothin may decrease the excretion rate of Lesinurad which could result in a higher serum level. |