Zolazepam

DB11555

small molecule vet_approved

Deskripsi

Zolazepam is a pyrazolodiazepinone derivative used as an anaesthetic in veterinary medicine. Zolazepam is typically used in combination with the NMDA antagonist tiletamine or the ?2 adrenoceptor agonist xylazine. It is around four times the potency of diazepam but it is both water-soluble and un-ionized at physiological pH meaning that its onset is very fast.

Struktur Molekul 2D

Berat 286.31
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

663 Data
Buprenorphine Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Hydrocodone Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Magnesium sulfate The therapeutic efficacy of Zolazepam can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Zolazepam may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Mirtazapine Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Orphenadrine Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Pramipexole Zolazepam may increase the sedative activities of Pramipexole.
Ropinirole Zolazepam may increase the sedative activities of Ropinirole.
Rotigotine Zolazepam may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Zolazepam.
Sodium oxybate The risk or severity of CNS depression can be increased when Sodium oxybate is combined with Zolazepam.
Suvorexant Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Thalidomide Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Yohimbine The therapeutic efficacy of Zolazepam can be increased when used in combination with Yohimbine.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Zolazepam.
Ethanol Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Zolazepam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Zimelidine The risk or severity of adverse effects can be increased when Zolazepam is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Zolazepam is combined with Dapoxetine.
Seproxetine The risk or severity of adverse effects can be increased when Zolazepam is combined with Seproxetine.
Fluvoxamine The risk or severity of adverse effects can be increased when Zolazepam is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Zolazepam is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Zolazepam is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Zolazepam is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Zolazepam is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Zolazepam is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Zolazepam is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Zolazepam is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Zolazepam is combined with Escitalopram.
Milnacipran The risk or severity of adverse effects can be increased when Zolazepam is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Zolazepam is combined with Desvenlafaxine.
Levomilnacipran The risk or severity of adverse effects can be increased when Levomilnacipran is combined with Zolazepam.
Indalpine The risk or severity of adverse effects can be increased when Zolazepam is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Zolazepam is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Zolazepam is combined with Alaproclate.
Cyproheptadine The risk or severity of CNS depression can be increased when Cyproheptadine is combined with Zolazepam.
Propiomazine The risk or severity of CNS depression can be increased when Propiomazine is combined with Zolazepam.
Zopiclone The risk or severity of adverse effects can be increased when Zolazepam is combined with Zopiclone.
Botulinum toxin type B The risk or severity of CNS depression can be increased when Botulinum toxin type B is combined with Zolazepam.
Botulinum toxin type A The risk or severity of CNS depression can be increased when Botulinum toxin type A is combined with Zolazepam.
Baclofen Baclofen may increase the central nervous system depressant (CNS depressant) activities of Zolazepam.
Ethchlorvynol The risk or severity of CNS depression can be increased when Ethchlorvynol is combined with Zolazepam.
Succinylcholine The risk or severity of CNS depression can be increased when Succinylcholine is combined with Zolazepam.
Eletriptan The risk or severity of CNS depression can be increased when Eletriptan is combined with Zolazepam.
Enflurane The risk or severity of CNS depression can be increased when Enflurane is combined with Zolazepam.
Butabarbital The risk or severity of CNS depression can be increased when Butabarbital is combined with Zolazepam.
Butalbital The risk or severity of CNS depression can be increased when Butalbital is combined with Zolazepam.
Methysergide The risk or severity of CNS depression can be increased when Methysergide is combined with Zolazepam.
Cabergoline The risk or severity of CNS depression can be increased when Cabergoline is combined with Zolazepam.
Phenytoin The risk or severity of CNS depression can be increased when Phenytoin is combined with Zolazepam.
Topiramate The risk or severity of CNS depression can be increased when Topiramate is combined with Zolazepam.
Clemastine The risk or severity of CNS depression can be increased when Clemastine is combined with Zolazepam.
Etomidate The risk or severity of CNS depression can be increased when Etomidate is combined with Zolazepam.
Morphine The risk or severity of CNS depression can be increased when Morphine is combined with Zolazepam.
Talbutal The risk or severity of CNS depression can be increased when Talbutal is combined with Zolazepam.
Pentobarbital The risk or severity of CNS depression can be increased when Pentobarbital is combined with Zolazepam.
Zolmitriptan The risk or severity of CNS depression can be increased when Zolmitriptan is combined with Zolazepam.
Codeine The risk or severity of CNS depression can be increased when Codeine is combined with Zolazepam.
Dihydroergotamine The risk or severity of CNS depression can be increased when Dihydroergotamine is combined with Zolazepam.
Tolcapone The risk or severity of CNS depression can be increased when Tolcapone is combined with Zolazepam.
Hydromorphone The risk or severity of CNS depression can be increased when Hydromorphone is combined with Zolazepam.
Cetirizine The risk or severity of CNS depression can be increased when Cetirizine is combined with Zolazepam.
Trimethadione The risk or severity of CNS depression can be increased when Trimethadione is combined with Zolazepam.
Chlorzoxazone The risk or severity of CNS depression can be increased when Chlorzoxazone is combined with Zolazepam.
Thiethylperazine The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Zolazepam.
Palonosetron The risk or severity of CNS depression can be increased when Palonosetron is combined with Zolazepam.
Dexbrompheniramine The risk or severity of CNS depression can be increased when Dexbrompheniramine is combined with Zolazepam.
Metocurine iodide The risk or severity of CNS depression can be increased when Metocurine iodide is combined with Zolazepam.
Secobarbital The risk or severity of CNS depression can be increased when Secobarbital is combined with Zolazepam.
Methocarbamol The risk or severity of CNS depression can be increased when Methocarbamol is combined with Zolazepam.
Triprolidine The risk or severity of CNS depression can be increased when Triprolidine is combined with Zolazepam.
Meperidine The risk or severity of CNS depression can be increased when Meperidine is combined with Zolazepam.
Metharbital The risk or severity of CNS depression can be increased when Metharbital is combined with Zolazepam.
Quinine The risk or severity of CNS depression can be increased when Quinine is combined with Zolazepam.
Methohexital The risk or severity of CNS depression can be increased when Methohexital is combined with Zolazepam.
Gallamine triethiodide The risk or severity of CNS depression can be increased when Gallamine triethiodide is combined with Zolazepam.
Entacapone The risk or severity of CNS depression can be increased when Entacapone is combined with Zolazepam.
Oxycodone The risk or severity of CNS depression can be increased when Oxycodone is combined with Zolazepam.
Dextromethorphan The risk or severity of CNS depression can be increased when Dextromethorphan is combined with Zolazepam.
Mephenytoin The risk or severity of CNS depression can be increased when Mephenytoin is combined with Zolazepam.
Cisatracurium The risk or severity of CNS depression can be increased when Cisatracurium is combined with Zolazepam.
Fenfluramine The risk or severity of CNS depression can be increased when Fenfluramine is combined with Zolazepam.
Mazindol The risk or severity of CNS depression can be increased when Mazindol is combined with Zolazepam.
Fluticasone propionate The risk or severity of CNS depression can be increased when Fluticasone propionate is combined with Zolazepam.
Lisuride The risk or severity of CNS depression can be increased when Lisuride is combined with Zolazepam.
Ethosuximide The risk or severity of CNS depression can be increased when Ethosuximide is combined with Zolazepam.
Thiopental The risk or severity of CNS depression can be increased when Thiopental is combined with Zolazepam.
Cisapride The risk or severity of CNS depression can be increased when Cisapride is combined with Zolazepam.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 15053744
    Natalini CC, Alves SD, Guedes AG, Polydoro AS, Brondani JT, Bopp S: Epidural administration of tiletamine/zolazepam in horses. Vet Anaesth Analg. 2004 Apr;31(2):79-85.
  • PMID: 2729719
    Hubbell JA, Bednarski RM, Muir WW: Xylazine and tiletamine-zolazepam anesthesia in horses. Am J Vet Res. 1989 May;50(5):737-42.
  • PMID: 7252822
    Hong WH, Szulczewski DH: Characteristics of equilibrium reaction of zolazepam. J Pharm Sci. 1981 Jun;70(6):691-3.
  • PMID: 8430114
    Wilson RP, Zagon IS, Larach DR, Lang CM: Cardiovascular and respiratory effects of tiletamine-zolazepam. Pharmacol Biochem Behav. 1993 Jan;44(1):1-8.
  • PMID: 14567228
    Cattet MR, Caulkett NA, Lunn NJ: Anesthesia of polar bears using xylazine-zolazepam-tiletamine or zolazepam-tiletamine. J Wildl Dis. 2003 Jul;39(3):655-64.
  • PMID: 7986185
    Lin HC, Wallace SS, Tyler JW, Robbins RL, Thurmon JC, Wolfe DF: Comparison of tiletamine-zolazepam-ketamine and tiletamine-zolazepam-ketamine-xylazine anaesthesia in sheep. Aust Vet J. 1994 Aug;71(8):239-42.
  • PMID: 10884126
    Fernandez-Moran J, Palomeque J, Peinado VI: Medetomidine/tiletamine/zolazepam and xylazine/tiletamine/zolazepam combinations for immobilization of fallow deer (Cervus dama). J Zoo Wildl Med. 2000 Mar;31(1):62-4.
  • PMID: 10642872
    Caulkett NA, Cattet MR, Cantwell S, Cool N, Olsen W: Anesthesia of wood bison with medetomidine-zolazepam/tiletamine and xylazine-zolazepam/tiletamine combinations. Can Vet J. 2000 Jan;41(1):49-53.
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