Pirlimycin

DB11537

small molecule vet_approved

Deskripsi

Pirlimycin hydrochloride is an antibiotic belonging to the lincosamide class. Often marketed as Pirsue, this drug is used to treat mastitis in cattle.

Struktur Molekul 2D

Berat 410.95
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

215 Data
Kaolin Kaolin can cause a decrease in the absorption of Pirlimycin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Pirlimycin.
Erythromycin The therapeutic efficacy of Erythromycin can be decreased when used in combination with Pirlimycin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Pirlimycin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Pirlimycin.
Dicoumarol The risk or severity of bleeding can be increased when Pirlimycin is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Pirlimycin is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Pirlimycin is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Pirlimycin is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Pirlimycin is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Pirlimycin is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Pirlimycin is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Pirlimycin is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Pirlimycin is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Pirlimycin is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Pirlimycin is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Pirlimycin is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Pirlimycin is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Pirlimycin is combined with (S)-Warfarin.
Cyclosporine Cyclosporine may increase the neurotoxic activities of Pirlimycin.
Reserpine Reserpine may increase the neurotoxic activities of Pirlimycin.
Ziprasidone Ziprasidone may increase the neurotoxic activities of Pirlimycin.
Cycloserine Cycloserine may increase the neurotoxic activities of Pirlimycin.
Amitriptyline Amitriptyline may increase the neurotoxic activities of Pirlimycin.
Protriptyline Protriptyline may increase the neurotoxic activities of Pirlimycin.
Vinorelbine Vinorelbine may increase the neurotoxic activities of Pirlimycin.
Clozapine Clozapine may increase the neurotoxic activities of Pirlimycin.
Thiethylperazine Thiethylperazine may increase the neurotoxic activities of Pirlimycin.
Sulpiride Sulpiride may increase the neurotoxic activities of Pirlimycin.
Loxapine Loxapine may increase the neurotoxic activities of Pirlimycin.
Remoxipride Remoxipride may increase the neurotoxic activities of Pirlimycin.
Promazine Promazine may increase the neurotoxic activities of Pirlimycin.
Prochlorperazine Prochlorperazine may increase the neurotoxic activities of Pirlimycin.
Teniposide Teniposide may increase the neurotoxic activities of Pirlimycin.
Droperidol Droperidol may increase the neurotoxic activities of Pirlimycin.
Imipramine Imipramine may increase the neurotoxic activities of Pirlimycin.
Chlorpromazine Chlorpromazine may increase the neurotoxic activities of Pirlimycin.
Haloperidol Haloperidol may increase the neurotoxic activities of Pirlimycin.
Triflupromazine Triflupromazine may increase the neurotoxic activities of Pirlimycin.
Cyclophosphamide Cyclophosphamide may increase the neurotoxic activities of Pirlimycin.
Nortriptyline Nortriptyline may increase the neurotoxic activities of Pirlimycin.
Vincristine Vincristine may increase the neurotoxic activities of Pirlimycin.
Amoxapine Amoxapine may increase the neurotoxic activities of Pirlimycin.
Fluphenazine Fluphenazine may increase the neurotoxic activities of Pirlimycin.
Stavudine Stavudine may increase the neurotoxic activities of Pirlimycin.
Thioridazine Thioridazine may increase the neurotoxic activities of Pirlimycin.
Moricizine Moricizine may increase the neurotoxic activities of Pirlimycin.
Trimipramine Trimipramine may increase the neurotoxic activities of Pirlimycin.
Risperidone Risperidone may increase the neurotoxic activities of Pirlimycin.
Trifluoperazine Trifluoperazine may increase the neurotoxic activities of Pirlimycin.
Perphenazine Perphenazine may increase the neurotoxic activities of Pirlimycin.
Flupentixol Flupentixol may increase the neurotoxic activities of Pirlimycin.
Ethanol Ethanol may increase the neurotoxic activities of Pirlimycin.
Didanosine Didanosine may increase the neurotoxic activities of Pirlimycin.
Cyclobenzaprine Cyclobenzaprine may increase the neurotoxic activities of Pirlimycin.
Mesoridazine Mesoridazine may increase the neurotoxic activities of Pirlimycin.
Acetophenazine Acetophenazine may increase the neurotoxic activities of Pirlimycin.
Promethazine Promethazine may increase the neurotoxic activities of Pirlimycin.
Pimozide Pimozide may increase the neurotoxic activities of Pirlimycin.
Doxepin Doxepin may increase the neurotoxic activities of Pirlimycin.
Desipramine Desipramine may increase the neurotoxic activities of Pirlimycin.
Clindamycin Clindamycin may increase the neurotoxic activities of Pirlimycin.
Paclitaxel Paclitaxel may increase the neurotoxic activities of Pirlimycin.
Aripiprazole Aripiprazole may increase the neurotoxic activities of Pirlimycin.
Chlorprothixene Chlorprothixene may increase the neurotoxic activities of Pirlimycin.
Clomipramine Clomipramine may increase the neurotoxic activities of Pirlimycin.
Alimemazine Alimemazine may increase the neurotoxic activities of Pirlimycin.
Paliperidone Paliperidone may increase the neurotoxic activities of Pirlimycin.
Lithium cation Lithium cation may increase the neurotoxic activities of Pirlimycin.
Methotrimeprazine Methotrimeprazine may increase the neurotoxic activities of Pirlimycin.
Imipenem Imipenem may increase the neurotoxic activities of Pirlimycin.
Periciazine Periciazine may increase the neurotoxic activities of Pirlimycin.
Acepromazine Acepromazine may increase the neurotoxic activities of Pirlimycin.
Aceprometazine Aceprometazine may increase the neurotoxic activities of Pirlimycin.
Molindone Molindone may increase the neurotoxic activities of Pirlimycin.
Pipotiazine Pipotiazine may increase the neurotoxic activities of Pirlimycin.
Thioproperazine Thioproperazine may increase the neurotoxic activities of Pirlimycin.
Thiothixene Thiothixene may increase the neurotoxic activities of Pirlimycin.
Zuclopenthixol Zuclopenthixol may increase the neurotoxic activities of Pirlimycin.
Lincomycin Lincomycin may increase the neurotoxic activities of Pirlimycin.
Amineptine Amineptine may increase the neurotoxic activities of Pirlimycin.
Fluspirilene Fluspirilene may increase the neurotoxic activities of Pirlimycin.
Osanetant Osanetant may increase the neurotoxic activities of Pirlimycin.
Bifeprunox Bifeprunox may increase the neurotoxic activities of Pirlimycin.
Iloperidone Iloperidone may increase the neurotoxic activities of Pirlimycin.
Pimavanserin Pimavanserin may increase the neurotoxic activities of Pirlimycin.
BL-1020 BL-1020 may increase the neurotoxic activities of Pirlimycin.
Cariprazine Cariprazine may increase the neurotoxic activities of Pirlimycin.
Sertindole Sertindole may increase the neurotoxic activities of Pirlimycin.
Asenapine Asenapine may increase the neurotoxic activities of Pirlimycin.
Amisulpride Amisulpride may increase the neurotoxic activities of Pirlimycin.
Lurasidone Lurasidone may increase the neurotoxic activities of Pirlimycin.
Perospirone Perospirone may increase the neurotoxic activities of Pirlimycin.
Amperozide Amperozide may increase the neurotoxic activities of Pirlimycin.
Dimetacrine Dimetacrine may increase the neurotoxic activities of Pirlimycin.
Cyamemazine Cyamemazine may increase the neurotoxic activities of Pirlimycin.
Butriptyline Butriptyline may increase the neurotoxic activities of Pirlimycin.
Brexpiprazole Brexpiprazole may increase the neurotoxic activities of Pirlimycin.
Sodium citrate Sodium citrate may increase the neurotoxic activities of Pirlimycin.
Dosulepin Dosulepin may increase the neurotoxic activities of Pirlimycin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10435279
    Hornish RE, Roof RD, Wiest JR: Pirlimycin residue in bovine liver--a case of reverse metabolism. Analyst. 1998 Dec;123(12):2463-7.
  • PMID: 8517701
    Thornsberry C, Marler JK, Watts JL, Yancey RJ Jr: Activity of pirlimycin against pathogens from cows with mastitis and recommendations for disk diffusion tests. Antimicrob Agents Chemother. 1993 May;37(5):1122-6.
  • PMID: 9325575
    Heller DN: Determination of pirlimycin residue in milk by liquid chromatographic analysis of the 9-fluorenylmethyl chloroformate derivative. J AOAC Int. 1997 Sep-Oct;80(5):975-81.
  • PMID: 6480775
    Shah JA, Weber DJ: High-performance liquid chromatographic assay of pirlimycin in human serum and urine using 9-fluorenylmethylchloroformate. J Chromatogr. 1984 Jul 13;309(1):95-105.
  • PMID: 15453485
    Oliver SP, Gillespie BE, Ivey SJ, Lewis MJ, Johnson DL, Lamar KC, Moorehead H, Dowlen HH, Chester ST, Hallberg JW: Influence of prepartum pirlimycin hydrochloride or penicillin-novobiocin therapy on mastitis in heifers during early lactation. J Dairy Sci. 2004 Jun;87(6):1727-31.
  • PMID: 10211716
    Whittem T: Pharmacokinetics and milk discard times of pirlimycin after intramammary infusion: a population approach. J Vet Pharmacol Ther. 1999 Feb;22(1):41-51.
  • PMID: 6606809
    Kopia GA, Driscoll EM, Yeung KF, Lucchesi BR: Antiarrhythmic and cardiovascular actions of the new antibiotic agent pirlimycin adenylate. Pharmacology. 1983;27(5):255-66.
  • PMID: 15653527
    Deluyker HA, Van Oye SN, Boucher JF: Factors affecting cure and somatic cell count after pirlimycin treatment of subclinical mastitis in lactating cows. J Dairy Sci. 2005 Feb;88(2):604-14.
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Contoh Produk & Brand

Produk: 0 • International brands: 1
International Brands
  • Pirsue

Sekuens Gen/Protein (FASTA)

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