Masitinib

DB11526

small molecule investigational vet_approved

Deskripsi

Masitinib is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in dogs. It has been available in Europe since 2009, under the brand name Masivet. In the USA it is distributed under the name Kinavet and has been available for veterinaries since 2011.

Struktur Molekul 2D

Berat 498.65
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

39 Data
Darbepoetin alfa The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Masitinib.
Erythropoietin The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Masitinib.
Peginesatide The risk or severity of Thrombosis can be increased when Peginesatide is combined with Masitinib.
Methoxy polyethylene glycol-epoetin beta The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Masitinib.
Lidocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Quinisocaine.
Nelarabine The risk or severity of adverse effects can be increased when Nelarabine is combined with Masitinib.
Ambroxol The risk or severity of methemoglobinemia can be increased when Masitinib is combined with Ambroxol.
Etrasimod The risk or severity of immunosuppression can be increased when Masitinib is combined with Etrasimod.

Target Protein

Proto-oncogene tyrosine-protein kinase Src SRC

Referensi & Sumber

Artikel (PubMed)
  • PMID: 19664170
    Walker UA: More about masitinib. Arthritis Res Ther. 2009;11(4):120. doi: 10.1186/ar2734. Epub 2009 Jul 13.
  • PMID: 19533403
    Bellamy F, Bader T, Moussy A, Hermine O: Pharmacokinetics of masitinib in cats. Vet Res Commun. 2009 Dec;33(8):831-7. doi: 10.1007/s11259-009-9231-6.
  • PMID: 21953477
    Chaigne B, Lagier L, Aubourg A, de Muret A, Jonville-Bera AP, Machet L, Samimi M: Stevens-Johnson Syndrome induced by masitinib. Acta Derm Venereol. 2012 Mar;92(2):210-2. doi: 10.2340/00015555-1196.
  • PMID: 21314730
    Daly M, Sheppard S, Cohen N, Nabity M, Moussy A, Hermine O, Wilson H: Safety of masitinib mesylate in healthy cats. J Vet Intern Med. 2011 Mar-Apr;25(2):297-302. doi: 10.1111/j.1939-1676.2011.0687.x. Epub 2011 Feb 11.
  • PMID: 21257519
    Procoli F: Clinical trial on the efficacy of masitinib in canine IBD. Vet Rec. 2010 Nov 6;167(19):760. doi: 10.1136/vr.c6030.
  • PMID: 18823406
    Hahn KA, Ogilvie G, Rusk T, Devauchelle P, Leblanc A, Legendre A, Powers B, Leventhal PS, Kinet JP, Palmerini F, Dubreuil P, Moussy A, Hermine O: Masitinib is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med. 2008 Nov-Dec;22(6):1301-9. doi: 10.1111/j.1939-1676.2008.0190.x. Epub 2008 Sep 24.
  • PMID: 20391634
    Gentilini F: "Masitinib" is safe and effective for the treatment of canine mast cell tumors. J Vet Intern Med. 2010 Jan-Feb;24(1):6; author reply 7.
  • PMID: 21333567
    Thamm DH, Rose B, Kow K, Humbert M, Mansfield CD, Moussy A, Hermine O, Dubreuil P: Masitinib as a chemosensitizer of canine tumor cell lines: a proof of concept study. Vet J. 2012 Jan;191(1):131-4. doi: 10.1016/j.tvjl.2011.01.001. Epub 2011 Feb 17.
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Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • Kinavet
  • Masivet

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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