Maduramicin

DB11525

small molecule vet_approved

Deskripsi

Maduramicin is an antiprotozoal agent used in veterinary medicine as prophylaxis against coccidiosis. It is a naturally occurring compound which was first isolated from the actinomycete, Actinomadura rubra.

Struktur Molekul 2D

Berat 934.171
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

55 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Maduramicin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Maduramicin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Maduramicin.
Dicoumarol The risk or severity of bleeding can be increased when Maduramicin is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Maduramicin is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Maduramicin is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Maduramicin is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Maduramicin is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Maduramicin is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Maduramicin is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Maduramicin is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Maduramicin is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Maduramicin is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Maduramicin is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Maduramicin is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Maduramicin is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Maduramicin is combined with (S)-Warfarin.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Maduramicin.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Maduramicin.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Maduramicin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Quinisocaine.
Cisatracurium Maduramicin may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Maduramicin is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Maduramicin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16299200
    Sharma N, Bhalla A, Varma S, Jain S, Singh S: Toxicity of maduramicin. Emerg Med J. 2005 Dec;22(12):880-2.
  • PMID: 10431386
    Gutierrez-Lugo MT, Lotina-Hennsen B, Farres A, Sanchez S, Mata R: Phytotoxic and photosynthetic activities of maduramicin and maduramicin methyl ester. Z Naturforsch C. 1999 May-Jun;54(5-6):325-32.
  • PMID: 9226847
    Shlosberg A, Perl S, Harmelin A, Hanji V, Bellaiche M, Bogin E, Cohen R, Markusfeld-Nir O, Shpigel N, Eisenberg Z, Furman M, Brosh A, Holzer Z, Aharoni Y: Acute maduramicin toxicity in calves. Vet Rec. 1997 Jun 21;140(25):643-6.
  • PMID: 17423864
    Sanford SE, McNaughton C: Ontario. Inonophore (maduramicin) toxicity in pigs. Can Vet J. 1991 Sep;32(9):567.
  • PMID: 18671068
    Badiola JJ, Luco DF, Perez V, Vargas MA, Lujan L, Marin JF: Maduramicin and tiamulin compatibility in broiler chickens. Avian Pathol. 1994 Mar;23(1):3-17.
  • PMID: 7804225
    Arrowood MJ, Xie LT, Hurd MR: In vitro assays of maduramicin activity against Cryptosporidium parvum. J Eukaryot Microbiol. 1994 Sep-Oct;41(5):23S.
  • PMID: 3793623
    McGahren WJ, Morton GO, Siegel MM, Borders DB, James JC, Ellestad GA: Chemistry of maduramicin. II. Decarboxylation, abnormal ketalization and dehydration. J Antibiot (Tokyo). 1986 Nov;39(11):1541-50.
  • PMID: 3700246
    Ellestad GA, Canfield N, Leese RA, Morton GO, James JC, Siegel MM, McGahren WJ: Chemistry of maduramicin. I. Salt formation and normal ketalization. J Antibiot (Tokyo). 1986 Mar;39(3):447-56.
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