Difloxacin

DB11511

small molecule vet_approved

Deskripsi

Difloxacin is a synthetic fluoroquinolone used in veterinary. As an antibacterial, it presents a broad bactericidal spectrum and its effects are dependent on its concentration. However, it presents a reduced efficacy when compared to other fluoroquinolone antibacterials.

Struktur Molekul 2D

Berat 399.398
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

935 Data
Didanosine Didanosine can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Probenecid Probenecid may decrease the excretion rate of Difloxacin which could result in a higher serum level.
Quinapril Quinapril can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate Calcium acetate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sevelamer Sevelamer can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron Dextran Iron Dextran can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium Calcium can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium carbonate Calcium carbonate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum carbonate Lanthanum carbonate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric carboxymaltose Ferric carboxymaltose can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Iron sucrose Iron sucrose can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric pyrophosphate Ferric pyrophosphate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium citrate Calcium citrate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium gluconate Calcium gluconate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric sulfate Ferric sulfate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric cation Ferric cation can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tetraferric tricitrate decahydrate Tetraferric tricitrate decahydrate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lanthanum III cation Lanthanum III cation can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium polycarbophil Calcium polycarbophil can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ferric oxyhydroxide Ferric oxyhydroxide can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sucralfate Sucralfate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Zolmitriptan The metabolism of Zolmitriptan can be decreased when combined with Difloxacin.
Nitrofurantoin The therapeutic efficacy of Difloxacin can be decreased when used in combination with Nitrofurantoin.
Mycophenolate mofetil The serum concentration of Mycophenolate mofetil can be decreased when it is combined with Difloxacin.
Mycophenolic acid The serum concentration of Mycophenolic acid can be decreased when it is combined with Difloxacin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Difloxacin.
Insulin human The therapeutic efficacy of Insulin human can be increased when used in combination with Difloxacin.
Insulin lispro The therapeutic efficacy of Insulin lispro can be increased when used in combination with Difloxacin.
Insulin pork The therapeutic efficacy of Insulin pork can be increased when used in combination with Difloxacin.
Troglitazone The therapeutic efficacy of Troglitazone can be increased when used in combination with Difloxacin.
Glimepiride The therapeutic efficacy of Glimepiride can be increased when used in combination with Difloxacin.
Sulfisoxazole The therapeutic efficacy of Sulfisoxazole can be increased when used in combination with Difloxacin.
Acarbose The therapeutic efficacy of Acarbose can be increased when used in combination with Difloxacin.
Metformin The therapeutic efficacy of Metformin can be increased when used in combination with Difloxacin.
Sulfadiazine The therapeutic efficacy of Sulfadiazine can be increased when used in combination with Difloxacin.
Rosiglitazone The therapeutic efficacy of Rosiglitazone can be increased when used in combination with Difloxacin.
Acetohexamide The therapeutic efficacy of Acetohexamide can be increased when used in combination with Difloxacin.
Miglitol The therapeutic efficacy of Miglitol can be increased when used in combination with Difloxacin.
Chlorpropamide The therapeutic efficacy of Chlorpropamide can be increased when used in combination with Difloxacin.
Nateglinide The therapeutic efficacy of Nateglinide can be increased when used in combination with Difloxacin.
Pentamidine The therapeutic efficacy of Pentamidine can be increased when used in combination with Difloxacin.
Tolazamide The therapeutic efficacy of Tolazamide can be increased when used in combination with Difloxacin.
Repaglinide The therapeutic efficacy of Repaglinide can be increased when used in combination with Difloxacin.
Phenformin The therapeutic efficacy of Phenformin can be increased when used in combination with Difloxacin.
Sulfamethoxazole The therapeutic efficacy of Sulfamethoxazole can be increased when used in combination with Difloxacin.
Glyburide The therapeutic efficacy of Glyburide can be increased when used in combination with Difloxacin.
Glipizide The therapeutic efficacy of Glipizide can be increased when used in combination with Difloxacin.
Gliclazide The therapeutic efficacy of Gliclazide can be increased when used in combination with Difloxacin.
Tolbutamide The therapeutic efficacy of Tolbutamide can be increased when used in combination with Difloxacin.
Pioglitazone The therapeutic efficacy of Pioglitazone can be increased when used in combination with Difloxacin.
Bromocriptine The therapeutic efficacy of Bromocriptine can be increased when used in combination with Difloxacin.
Gliquidone The therapeutic efficacy of Gliquidone can be increased when used in combination with Difloxacin.
Mitiglinide The therapeutic efficacy of Mitiglinide can be increased when used in combination with Difloxacin.
Sitagliptin The therapeutic efficacy of Sitagliptin can be increased when used in combination with Difloxacin.
Sunitinib The therapeutic efficacy of Sunitinib can be increased when used in combination with Difloxacin.
Exenatide The therapeutic efficacy of Exenatide can be increased when used in combination with Difloxacin.
Mecasermin The therapeutic efficacy of Mecasermin can be increased when used in combination with Difloxacin.
Pramlintide The therapeutic efficacy of Pramlintide can be increased when used in combination with Difloxacin.
Glisoxepide The therapeutic efficacy of Glisoxepide can be increased when used in combination with Difloxacin.
Insulin aspart The therapeutic efficacy of Insulin aspart can be increased when used in combination with Difloxacin.
Insulin glulisine The therapeutic efficacy of Insulin glulisine can be increased when used in combination with Difloxacin.
Glymidine The therapeutic efficacy of Glymidine can be increased when used in combination with Difloxacin.
AICA ribonucleotide The therapeutic efficacy of AICA ribonucleotide can be increased when used in combination with Difloxacin.
Buformin The therapeutic efficacy of Buformin can be increased when used in combination with Difloxacin.
Vildagliptin The therapeutic efficacy of Vildagliptin can be increased when used in combination with Difloxacin.
Voglibose The therapeutic efficacy of Voglibose can be increased when used in combination with Difloxacin.
NN344 The therapeutic efficacy of NN344 can be increased when used in combination with Difloxacin.
AMG-222 The therapeutic efficacy of AMG-222 can be increased when used in combination with Difloxacin.
Bisegliptin The therapeutic efficacy of Bisegliptin can be increased when used in combination with Difloxacin.
Alogliptin The therapeutic efficacy of Alogliptin can be increased when used in combination with Difloxacin.
Dapagliflozin The therapeutic efficacy of Dapagliflozin can be increased when used in combination with Difloxacin.
Saxagliptin The therapeutic efficacy of Saxagliptin can be increased when used in combination with Difloxacin.
Liraglutide The therapeutic efficacy of Liraglutide can be increased when used in combination with Difloxacin.
Gosogliptin The therapeutic efficacy of Gosogliptin can be increased when used in combination with Difloxacin.
Linagliptin The therapeutic efficacy of Linagliptin can be increased when used in combination with Difloxacin.
Canagliflozin The therapeutic efficacy of Canagliflozin can be increased when used in combination with Difloxacin.
Glibornuride The therapeutic efficacy of Glibornuride can be increased when used in combination with Difloxacin.
Benfluorex The therapeutic efficacy of Benfluorex can be increased when used in combination with Difloxacin.
Empagliflozin The therapeutic efficacy of Empagliflozin can be increased when used in combination with Difloxacin.
Albiglutide The therapeutic efficacy of Albiglutide can be increased when used in combination with Difloxacin.
Dulaglutide The therapeutic efficacy of Dulaglutide can be increased when used in combination with Difloxacin.
Lobeglitazone The therapeutic efficacy of Lobeglitazone can be increased when used in combination with Difloxacin.
Netoglitazone The therapeutic efficacy of Netoglitazone can be increased when used in combination with Difloxacin.
Rivoglitazone The therapeutic efficacy of Rivoglitazone can be increased when used in combination with Difloxacin.
Ciglitazone The therapeutic efficacy of Ciglitazone can be increased when used in combination with Difloxacin.
Lixisenatide The therapeutic efficacy of Lixisenatide can be increased when used in combination with Difloxacin.
Insulin beef The therapeutic efficacy of Insulin beef can be increased when used in combination with Difloxacin.
Insulin degludec The therapeutic efficacy of Insulin degludec can be increased when used in combination with Difloxacin.
Insulin peglispro The therapeutic efficacy of Insulin peglispro can be increased when used in combination with Difloxacin.
Insulin tregopil The therapeutic efficacy of Insulin tregopil can be increased when used in combination with Difloxacin.
Ipragliflozin The therapeutic efficacy of Ipragliflozin can be increased when used in combination with Difloxacin.
Dutogliptin The therapeutic efficacy of Dutogliptin can be increased when used in combination with Difloxacin.
Allicin The therapeutic efficacy of Allicin can be increased when used in combination with Difloxacin.
Tofogliflozin The therapeutic efficacy of Tofogliflozin can be increased when used in combination with Difloxacin.
Ertugliflozin The therapeutic efficacy of Ertugliflozin can be increased when used in combination with Difloxacin.
2,4-thiazolidinedione The therapeutic efficacy of 2,4-thiazolidinedione can be increased when used in combination with Difloxacin.
Teneligliptin The therapeutic efficacy of Teneligliptin can be increased when used in combination with Difloxacin.
Omarigliptin The therapeutic efficacy of Omarigliptin can be increased when used in combination with Difloxacin.
Carmegliptin The therapeutic efficacy of Carmegliptin can be increased when used in combination with Difloxacin.
Gemigliptin The therapeutic efficacy of Gemigliptin can be increased when used in combination with Difloxacin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12161971
    Atef M, el-Banna HA, Abd El-Aty AM, Goudah A: Pharmacokinetics of difloxacin in goats. Dtsch Tierarztl Wochenschr. 2002 Jul;109(7):320-3.
  • PMID: 19751946
    Prabhakaran D, Sukul P, Lamshoft M, Maheswari MA, Zuhlke S, Spiteller M: Photolysis of difloxacin and sarafloxacin in aqueous systems. Chemosphere. 2009 Oct;77(6):739-46. doi: 10.1016/j.chemosphere.2009.08.031. Epub 2009 Sep 13.
  • PMID: 10850850
    Olchowy TW, TerHune TN, Herrick RL: Efficacy of difloxacin in calves experimentally infected with Mannheimia haemolytica. Am J Vet Res. 2000 Jun;61(6):710-3.
  • PMID: 3800345
    Granneman GR, Snyder KM, Shu VS: Difloxacin metabolism and pharmacokinetics in humans after single oral doses. Antimicrob Agents Chemother. 1986 Nov;30(5):689-93.
  • PMID: 15953209
    Mavrogianni VS, Fthenakis GC: Efficacy of difloxacin against respiratory infections of lambs. J Vet Pharmacol Ther. 2005 Jun;28(3):325-8.
  • PMID: 10826834
    van den Hoven R, Wagenaar JA, Walker RD: In vitro activity of difloxacin against canine bacterial isolates. J Vet Diagn Invest. 2000 May;12(3):218-23.
  • PMID: 19181312
    Sukul P, Lamshoft M, Kusari S, Zuhlke S, Spiteller M: Metabolism and excretion kinetics of 14C-labeled and non-labeled difloxacin in pigs after oral administration, and antimicrobial activity of manure containing difloxacin and its metabolites. Environ Res. 2009 Apr;109(3):225-31. doi: 10.1016/j.envres.2008.12.007. Epub 2009 Jan 31.
  • PMID: 3521473
    Fernandes PB, Chu DT, Bower RR, Jarvis KP, Ramer NR, Shipkowitz N: In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986 Feb;29(2):201-8.
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