Nalorphine

DB11490

small molecule experimental vet_approved

Deskripsi

Nalorphine is a mixed opioid agonist–antagonist. It acts at two opioid receptors—at the mu receptor it has antagonistic effects, and at the kappa receptors it exerts high-efficacy agonistic characteristics. It is used to reverse opioid overdose and (starting in the 1950s) in a challenge test to determine opioid dependence.

Struktur Molekul 2D

Berat 311.381
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

54 Data
Methylnaltrexone Nalorphine may increase the opioid antagonism activities of Methylnaltrexone.
Naloxegol Nalorphine may increase the opioid antagonism activities of Naloxegol.
Tramadol The therapeutic efficacy of Tramadol can be decreased when used in combination with Nalorphine.
Morphine The therapeutic efficacy of Morphine can be decreased when used in combination with Nalorphine.
Codeine The therapeutic efficacy of Codeine can be decreased when used in combination with Nalorphine.
Hydromorphone The therapeutic efficacy of Hydromorphone can be decreased when used in combination with Nalorphine.
Methadone The therapeutic efficacy of Methadone can be decreased when used in combination with Nalorphine.
Meperidine The therapeutic efficacy of Meperidine can be decreased when used in combination with Nalorphine.
Oxycodone The therapeutic efficacy of Oxycodone can be decreased when used in combination with Nalorphine.
Butorphanol The therapeutic efficacy of Butorphanol can be decreased when used in combination with Nalorphine.
Dextropropoxyphene The therapeutic efficacy of Dextropropoxyphene can be decreased when used in combination with Nalorphine.
Pentazocine The therapeutic efficacy of Pentazocine can be decreased when used in combination with Nalorphine.
Naltrexone The therapeutic efficacy of Naltrexone can be decreased when used in combination with Nalorphine.
Sufentanil The therapeutic efficacy of Sufentanil can be decreased when used in combination with Nalorphine.
Alfentanil The therapeutic efficacy of Alfentanil can be decreased when used in combination with Nalorphine.
Fentanyl The therapeutic efficacy of Fentanyl can be decreased when used in combination with Nalorphine.
Nalbuphine The therapeutic efficacy of Nalbuphine can be decreased when used in combination with Nalorphine.
Levorphanol The therapeutic efficacy of Levorphanol can be decreased when used in combination with Nalorphine.
Remifentanil The therapeutic efficacy of Remifentanil can be decreased when used in combination with Nalorphine.
Buprenorphine The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Nalorphine.
Hydrocodone The therapeutic efficacy of Hydrocodone can be decreased when used in combination with Nalorphine.
Diphenoxylate The therapeutic efficacy of Diphenoxylate can be decreased when used in combination with Nalorphine.
Oxymorphone The therapeutic efficacy of Oxymorphone can be decreased when used in combination with Nalorphine.
Dezocine The therapeutic efficacy of Dezocine can be decreased when used in combination with Nalorphine.
Levacetylmethadol The therapeutic efficacy of Levacetylmethadol can be decreased when used in combination with Nalorphine.
Methadyl acetate The therapeutic efficacy of Methadyl acetate can be decreased when used in combination with Nalorphine.
Dihydroetorphine The therapeutic efficacy of Dihydroetorphine can be decreased when used in combination with Nalorphine.
Diamorphine The therapeutic efficacy of Diamorphine can be decreased when used in combination with Nalorphine.
Bezitramide The therapeutic efficacy of Bezitramide can be decreased when used in combination with Nalorphine.
Ethylmorphine The therapeutic efficacy of Ethylmorphine can be decreased when used in combination with Nalorphine.
Etorphine The therapeutic efficacy of Etorphine can be decreased when used in combination with Nalorphine.
Dextromoramide The therapeutic efficacy of Dextromoramide can be decreased when used in combination with Nalorphine.
Desomorphine The therapeutic efficacy of Desomorphine can be decreased when used in combination with Nalorphine.
Carfentanil The therapeutic efficacy of Carfentanil can be decreased when used in combination with Nalorphine.
Dihydrocodeine The therapeutic efficacy of Dihydrocodeine can be decreased when used in combination with Nalorphine.
Alphacetylmethadol The therapeutic efficacy of Alphacetylmethadol can be decreased when used in combination with Nalorphine.
Dihydromorphine The therapeutic efficacy of Dihydromorphine can be decreased when used in combination with Nalorphine.
Tapentadol The therapeutic efficacy of Tapentadol can be decreased when used in combination with Nalorphine.
Ketobemidone The therapeutic efficacy of Ketobemidone can be decreased when used in combination with Nalorphine.
DPDPE The therapeutic efficacy of DPDPE can be decreased when used in combination with Nalorphine.
Lofentanil The therapeutic efficacy of Lofentanil can be decreased when used in combination with Nalorphine.
Eluxadoline The therapeutic efficacy of Eluxadoline can be decreased when used in combination with Nalorphine.
Opium The therapeutic efficacy of Opium can be decreased when used in combination with Nalorphine.
Normethadone The therapeutic efficacy of Normethadone can be decreased when used in combination with Nalorphine.
Piritramide The therapeutic efficacy of Piritramide can be decreased when used in combination with Nalorphine.
Alphaprodine The therapeutic efficacy of Alphaprodine can be decreased when used in combination with Nalorphine.
Nicomorphine The therapeutic efficacy of Nicomorphine can be decreased when used in combination with Nalorphine.
Meptazinol The therapeutic efficacy of Meptazinol can be decreased when used in combination with Nalorphine.
Phenoperidine The therapeutic efficacy of Phenoperidine can be decreased when used in combination with Nalorphine.
Phenazocine The therapeutic efficacy of Phenazocine can be decreased when used in combination with Nalorphine.
Tilidine The therapeutic efficacy of Tilidine can be decreased when used in combination with Nalorphine.
Carfentanil, C-11 The therapeutic efficacy of Carfentanil, C-11 can be decreased when used in combination with Nalorphine.
Benzhydrocodone The therapeutic efficacy of Benzhydrocodone can be decreased when used in combination with Nalorphine.
Oliceridine The therapeutic efficacy of Oliceridine can be decreased when used in combination with Nalorphine.

Target Protein

Kappa-type opioid receptor OPRK1

Referensi & Sumber

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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