Zeranol

DB11478

small molecule experimental vet_approved

Deskripsi

Zeranol is a non-steroidal estrogen agonist. It is a mycotoxin, derived from fungi in the Fusarium family, and may be found as a contaminant in fungus-infected crops. It is 3-4x more potent as an estrogen agonist than the related compound zearalenone.

Struktur Molekul 2D

Berat 322.401
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

549 Data
Prasterone The risk or severity of adverse effects can be increased when Prasterone is combined with Zeranol.
Exemestane The therapeutic efficacy of Exemestane can be decreased when used in combination with Zeranol.
Hyaluronidase (ovine) The therapeutic efficacy of Hyaluronidase (ovine) can be decreased when used in combination with Zeranol.
Hyaluronidase (human recombinant) The therapeutic efficacy of Hyaluronidase (human recombinant) can be decreased when used in combination with Zeranol.
Hyaluronidase The therapeutic efficacy of Hyaluronidase can be decreased when used in combination with Zeranol.
Lenalidomide Zeranol may increase the thrombogenic activities of Lenalidomide.
Ospemifene The risk or severity of adverse effects can be increased when Zeranol is combined with Ospemifene.
Ropinirole Zeranol may increase the excretion rate of Ropinirole which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide Zeranol may increase the thrombogenic activities of Thalidomide.
Cetuximab Zeranol may increase the thrombogenic activities of Cetuximab.
Human immunoglobulin G Zeranol may increase the thrombogenic activities of Human immunoglobulin G.
Omalizumab Zeranol may increase the thrombogenic activities of Omalizumab.
Adalimumab Zeranol may increase the thrombogenic activities of Adalimumab.
Gemtuzumab ozogamicin Zeranol may increase the thrombogenic activities of Gemtuzumab ozogamicin.
Indium In-111 satumomab pendetide Zeranol may increase the thrombogenic activities of Indium In-111 satumomab pendetide.
Infliximab Zeranol may increase the thrombogenic activities of Infliximab.
Trastuzumab Zeranol may increase the thrombogenic activities of Trastuzumab.
Rituximab Zeranol may increase the thrombogenic activities of Rituximab.
Basiliximab Zeranol may increase the thrombogenic activities of Basiliximab.
Muromonab Zeranol may increase the thrombogenic activities of Muromonab.
Digoxin Immune Fab (Ovine) Zeranol may increase the thrombogenic activities of Digoxin Immune Fab (Ovine).
Ibritumomab tiuxetan Zeranol may increase the thrombogenic activities of Ibritumomab tiuxetan.
Tositumomab Zeranol may increase the thrombogenic activities of Tositumomab.
Alemtuzumab Zeranol may increase the thrombogenic activities of Alemtuzumab.
Capromab pendetide Zeranol may increase the thrombogenic activities of Capromab pendetide.
Efalizumab Zeranol may increase the thrombogenic activities of Efalizumab.
Antithymocyte immunoglobulin (rabbit) Zeranol may increase the thrombogenic activities of Antithymocyte immunoglobulin (rabbit).
Natalizumab Zeranol may increase the thrombogenic activities of Natalizumab.
Palivizumab Zeranol may increase the thrombogenic activities of Palivizumab.
Daclizumab Zeranol may increase the thrombogenic activities of Daclizumab.
Bevacizumab Zeranol may increase the thrombogenic activities of Bevacizumab.
Technetium Tc-99m arcitumomab Zeranol may increase the thrombogenic activities of Technetium Tc-99m arcitumomab.
Eculizumab Zeranol may increase the thrombogenic activities of Eculizumab.
Panitumumab Zeranol may increase the thrombogenic activities of Panitumumab.
Ranibizumab Zeranol may increase the thrombogenic activities of Ranibizumab.
Galiximab Zeranol may increase the thrombogenic activities of Galiximab.
Pexelizumab Zeranol may increase the thrombogenic activities of Pexelizumab.
Afelimomab Zeranol may increase the thrombogenic activities of Afelimomab.
Epratuzumab Zeranol may increase the thrombogenic activities of Epratuzumab.
Bectumomab Zeranol may increase the thrombogenic activities of Bectumomab.
Oregovomab Zeranol may increase the thrombogenic activities of Oregovomab.
IGN311 Zeranol may increase the thrombogenic activities of IGN311.
Adecatumumab Zeranol may increase the thrombogenic activities of Adecatumumab.
Labetuzumab Zeranol may increase the thrombogenic activities of Labetuzumab.
Matuzumab Zeranol may increase the thrombogenic activities of Matuzumab.
Fontolizumab Zeranol may increase the thrombogenic activities of Fontolizumab.
Bavituximab Zeranol may increase the thrombogenic activities of Bavituximab.
CR002 Zeranol may increase the thrombogenic activities of CR002.
Rozrolimupab Zeranol may increase the thrombogenic activities of Rozrolimupab.
Girentuximab Zeranol may increase the thrombogenic activities of Girentuximab.
Obiltoxaximab Zeranol may increase the thrombogenic activities of Obiltoxaximab.
XTL-001 Zeranol may increase the thrombogenic activities of XTL-001.
NAV 1800 Zeranol may increase the thrombogenic activities of NAV 1800.
Briakinumab Zeranol may increase the thrombogenic activities of Briakinumab.
Otelixizumab Zeranol may increase the thrombogenic activities of Otelixizumab.
AMG 108 Zeranol may increase the thrombogenic activities of AMG 108.
Iratumumab Zeranol may increase the thrombogenic activities of Iratumumab.
Enokizumab Zeranol may increase the thrombogenic activities of Enokizumab.
Ramucirumab Zeranol may increase the thrombogenic activities of Ramucirumab.
Farletuzumab Zeranol may increase the thrombogenic activities of Farletuzumab.
Veltuzumab Zeranol may increase the thrombogenic activities of Veltuzumab.
Ustekinumab Zeranol may increase the thrombogenic activities of Ustekinumab.
Trastuzumab emtansine Zeranol may increase the thrombogenic activities of Trastuzumab emtansine.
PRO-542 Zeranol may increase the thrombogenic activities of PRO-542.
TNX-901 Zeranol may increase the thrombogenic activities of TNX-901.
Inotuzumab ozogamicin Zeranol may increase the thrombogenic activities of Inotuzumab ozogamicin.
RI 624 Zeranol may increase the thrombogenic activities of RI 624.
Stamulumab Zeranol may increase the thrombogenic activities of MYO-029.
CT-011 Zeranol may increase the thrombogenic activities of CT-011.
Leronlimab Zeranol may increase the thrombogenic activities of Leronlimab.
Glembatumumab vedotin Zeranol may increase the thrombogenic activities of Glembatumumab vedotin.
Olaratumab Zeranol may increase the thrombogenic activities of Olaratumab.
IPH 2101 Zeranol may increase the thrombogenic activities of IPH 2101.
TB-402 Zeranol may increase the thrombogenic activities of TB-402.
Caplacizumab Zeranol may increase the thrombogenic activities of Caplacizumab.
IMC-1C11 Zeranol may increase the thrombogenic activities of IMC-1C11.
Eldelumab Zeranol may increase the thrombogenic activities of Eldelumab.
Lumiliximab Zeranol may increase the thrombogenic activities of Lumiliximab.
Canakinumab Zeranol may increase the thrombogenic activities of Canakinumab.
Ipilimumab Zeranol may increase the thrombogenic activities of Ipilimumab.
Nimotuzumab Zeranol may increase the thrombogenic activities of Nimotuzumab.
Clenoliximab Zeranol may increase the thrombogenic activities of Clenoliximab.
Tocilizumab Zeranol may increase the thrombogenic activities of Tocilizumab.
BIIB015 Zeranol may increase the thrombogenic activities of BIIB015.
Sonepcizumab Zeranol may increase the thrombogenic activities of Sonepcizumab.
Motavizumab Zeranol may increase the thrombogenic activities of Motavizumab.
Elotuzumab Zeranol may increase the thrombogenic activities of Elotuzumab.
AVE9633 Zeranol may increase the thrombogenic activities of AVE9633.
Carotuximab Zeranol may increase the thrombogenic activities of Carotuximab.
XmAb 2513 Zeranol may increase the thrombogenic activities of XmAb 2513.
Coltuximab ravtansine Zeranol may increase the thrombogenic activities of Coltuximab ravtansine.
Lucatumumab Zeranol may increase the thrombogenic activities of Lucatumumab.
Pertuzumab Zeranol may increase the thrombogenic activities of Pertuzumab.
Siplizumab Zeranol may increase the thrombogenic activities of Siplizumab.
Apolizumab Zeranol may increase the thrombogenic activities of Apolizumab.
Sibrotuzumab Zeranol may increase the thrombogenic activities of Sibrotuzumab.
Bivatuzumab Zeranol may increase the thrombogenic activities of Bivatuzumab.
Lerdelimumab Zeranol may increase the thrombogenic activities of Lerdelimumab.
Lexatumumab Zeranol may increase the thrombogenic activities of Lexatumumab.
Reslizumab Zeranol may increase the thrombogenic activities of Reslizumab.

Target Protein

Estrogen receptor ESR1
Sex hormone-binding globulin SHBG

Referensi & Sumber

Artikel (PubMed)
  • PMID: 16726026
    Juniewicz PE, Welsh TH Jr, Johnson BH: Effects of zeranol upon bovine testicular function. Theriogenology. 1985 Apr;23(4):565-82.
  • PMID: 8440661
    Pusateri AE, Kenison DC: Measurement of zeranol in plasma from three blood vessels in steers implanted with zeranol. J Anim Sci. 1993 Feb;71(2):415-9.
  • PMID: 16031223
    McKenzie JR: Zeranol and adult steers. N Z Vet J. 1986 Jan-Feb;34(1-2):19.
  • PMID: 16030974
    McKenzie JR: Zeranol and fattening bulls. N Z Vet J. 1983 Jun;31(6):104-5.
  • PMID: 2931335
    Lindsay DG: Zeranol--a 'nature-identical' oestrogen? Food Chem Toxicol. 1985 Aug;23(8):767-74.
  • PMID: 3701919
    Dixon SN, Mallinson CB: Radioimmunoassay of the anabolic agent zeranol. III. Zeranol concentrations in the faeces of steers implanted with zeranol (Ralgro). J Vet Pharmacol Ther. 1986 Mar;9(1):88-93.
  • PMID: 6632074
    Dixon SN, Russell KL: Radioimmunoassay of the anabolic agent zeranol. II. Zeranol concentrations in urine of sheep and cattle implanted with zeranol (Ralgro). J Vet Pharmacol Ther. 1983 Sep;6(3):173-9.
  • PMID: 3425550
    Neumeister CE: Environmental sampling and analysis for zeranol. Am Ind Hyg Assoc J. 1987 Nov;48(11):919-21.
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