Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats.A9095,L42675,A251420 It acts as an agonist at ?2 adrenoceptors; however, its affinity is lower than the one reported for other ?2 adrenergic receptor agonists such as detomidine and medetomidine.A32545 Xylazine is not approved for human use and requires a veterinary licence for its purchase and use.L42680 The intentional and unintentional use of xylazine is a cause for concern due to its side effects.A9096 The use of xylazine can lead to hypotension and bradycardiaA9092,A9093, and when combined with central nervous system depressants, such as benzodiazepines or alcohol, it can significantly depress vital functions and increase the risk of overdose and death.L42675 Xylazine is sometimes used as an adulterant and combined with opioids and recreational drugs; however, it has no antidote, and the use of naloxone has no effect on xylazine.L42675,L42680
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Valsartan | Xylazine may decrease the antihypertensive activities of Valsartan. |
| Ramipril | Xylazine may decrease the antihypertensive activities of Ramipril. |
| Remikiren | Xylazine may decrease the antihypertensive activities of Remikiren. |
| Torasemide | Xylazine may decrease the antihypertensive activities of Torasemide. |
| Isradipine | Xylazine may decrease the antihypertensive activities of Isradipine. |
| Olmesartan | Xylazine may decrease the antihypertensive activities of Olmesartan. |
| Chlorthalidone | Xylazine may decrease the antihypertensive activities of Chlorthalidone. |
| Nitroprusside | Xylazine may decrease the antihypertensive activities of Nitroprusside. |
| Diltiazem | Xylazine may decrease the antihypertensive activities of Diltiazem. |
| Minoxidil | Xylazine may decrease the antihypertensive activities of Minoxidil. |
| Treprostinil | Xylazine may decrease the antihypertensive activities of Treprostinil. |
| Amlodipine | Xylazine may decrease the antihypertensive activities of Amlodipine. |
| Nimodipine | Xylazine may decrease the antihypertensive activities of Nimodipine. |
| Nisoldipine | Xylazine may decrease the antihypertensive activities of Nisoldipine. |
| Bendroflumethiazide | Xylazine may decrease the antihypertensive activities of Bendroflumethiazide. |
| Fosinopril | Xylazine may decrease the antihypertensive activities of Fosinopril. |
| Trandolapril | Xylazine may decrease the antihypertensive activities of Trandolapril. |
| Metolazone | Xylazine may decrease the antihypertensive activities of Metolazone. |
| Lercanidipine | Xylazine may decrease the antihypertensive activities of Lercanidipine. |
| Benazepril | Xylazine may decrease the antihypertensive activities of Benazepril. |
| Bosentan | Xylazine may decrease the antihypertensive activities of Bosentan. |
| Enalapril | Xylazine may decrease the antihypertensive activities of Enalapril. |
| Cyclothiazide | Xylazine may decrease the antihypertensive activities of Cyclothiazide. |
| Candoxatril | Xylazine may decrease the antihypertensive activities of Candoxatril. |
| Mecamylamine | Xylazine may decrease the antihypertensive activities of Mecamylamine. |
| Losartan | Xylazine may decrease the antihypertensive activities of Losartan. |
| Moexipril | Xylazine may decrease the antihypertensive activities of Moexipril. |
| Eplerenone | Xylazine may decrease the antihypertensive activities of Eplerenone. |
| Lisinopril | Xylazine may decrease the antihypertensive activities of Lisinopril. |
| Nitroglycerin | Xylazine may decrease the antihypertensive activities of Nitroglycerin. |
| Hydroflumethiazide | Xylazine may decrease the antihypertensive activities of Hydroflumethiazide. |
| Cryptenamine | Xylazine may decrease the antihypertensive activities of Cryptenamine. |
| Perindopril | Xylazine may decrease the antihypertensive activities of Perindopril. |
| Candesartan cilexetil | Xylazine may decrease the antihypertensive activities of Candesartan cilexetil. |
| Fenoldopam | Xylazine may decrease the antihypertensive activities of Fenoldopam. |
| Indapamide | Xylazine may decrease the antihypertensive activities of Indapamide. |
| Tadalafil | Xylazine may decrease the antihypertensive activities of Tadalafil. |
| Eprosartan | Xylazine may decrease the antihypertensive activities of Eprosartan. |
| Chlorothiazide | Xylazine may decrease the antihypertensive activities of Chlorothiazide. |
| Quinapril | Xylazine may decrease the antihypertensive activities of Quinapril. |
| Telmisartan | Xylazine may decrease the antihypertensive activities of Telmisartan. |
| Methyldopa | Xylazine may decrease the antihypertensive activities of Methyldopa. |
| Hydrochlorothiazide | Xylazine may decrease the antihypertensive activities of Hydrochlorothiazide. |
| Trichlormethiazide | Xylazine may decrease the antihypertensive activities of Trichlormethiazide. |
| Irbesartan | Xylazine may decrease the antihypertensive activities of Irbesartan. |
| Nitrendipine | Xylazine may decrease the antihypertensive activities of Nitrendipine. |
| Deserpidine | Xylazine may decrease the antihypertensive activities of Deserpidine. |
| Pentolinium | Xylazine may decrease the antihypertensive activities of Pentolinium. |
| Trimethaphan | Xylazine may decrease the antihypertensive activities of Trimethaphan. |
| Diazoxide | Xylazine may decrease the antihypertensive activities of Diazoxide. |
| Captopril | Xylazine may decrease the antihypertensive activities of Captopril. |
| Epoprostenol | Xylazine may decrease the antihypertensive activities of Epoprostenol. |
| Bepridil | Xylazine may decrease the antihypertensive activities of Bepridil. |
| Hydralazine | Xylazine may decrease the antihypertensive activities of Hydralazine. |
| Polythiazide | Xylazine may decrease the antihypertensive activities of Polythiazide. |
| Cilazapril | Xylazine may decrease the antihypertensive activities of Cilazapril. |
| Saprisartan | Xylazine may decrease the antihypertensive activities of Saprisartan. |
| Spirapril | Xylazine may decrease the antihypertensive activities of Spirapril. |
| Mibefradil | Xylazine may decrease the antihypertensive activities of Mibefradil. |
| Tienilic acid | Xylazine may decrease the antihypertensive activities of Tienilic acid. |
| Debrisoquine | Xylazine may decrease the antihypertensive activities of Debrisoquine. |
| Sitaxentan | Xylazine may decrease the antihypertensive activities of Sitaxentan. |
| Ambrisentan | Xylazine may decrease the antihypertensive activities of Ambrisentan. |
| Diethylnorspermine | Xylazine may decrease the antihypertensive activities of Diethylnorspermine. |
| Nilvadipine | Xylazine may decrease the antihypertensive activities of Nilvadipine. |
| Pinacidil | Xylazine may decrease the antihypertensive activities of Pinacidil. |
| Temocapril | Xylazine may decrease the antihypertensive activities of Temocapril. |
| Riociguat | Xylazine may decrease the antihypertensive activities of Riociguat. |
| Macitentan | Xylazine may decrease the antihypertensive activities of Macitentan. |
| Aliskiren | Xylazine may decrease the antihypertensive activities of Aliskiren. |
| Nicorandil | Xylazine may decrease the antihypertensive activities of Nicorandil. |
| Efonidipine | Xylazine may decrease the antihypertensive activities of Efonidipine. |
| Lacidipine | Xylazine may decrease the antihypertensive activities of Lacidipine. |
| Manidipine | Xylazine may decrease the antihypertensive activities of Manidipine. |
| Rauwolfia serpentina root | Xylazine may decrease the antihypertensive activities of Rauwolfia serpentina root. |
| Enalaprilat | Xylazine may decrease the antihypertensive activities of Enalaprilat. |
| Selexipag | Xylazine may decrease the antihypertensive activities of Selexipag. |
| Angiotensin 1-7 | Xylazine may decrease the antihypertensive activities of Angiotensin 1-7. |
| Imidapril | Xylazine may decrease the antihypertensive activities of Imidapril. |
| BQ-123 | Xylazine may decrease the antihypertensive activities of BQ-123. |
| Cicletanine | Xylazine may decrease the antihypertensive activities of Cicletanine. |
| Dihydralazine | Xylazine may decrease the antihypertensive activities of Dihydralazine. |
| Zofenopril | Xylazine may decrease the antihypertensive activities of Zofenopril. |
| Guanoxan | Xylazine may decrease the antihypertensive activities of Guanoxan. |
| Delapril | Xylazine may decrease the antihypertensive activities of Delapril. |
| Vincamine | Xylazine may decrease the antihypertensive activities of Vincamine. |
| Linsidomine | Xylazine may decrease the antihypertensive activities of Linsidomine. |
| Guanoxabenz | Xylazine may decrease the antihypertensive activities of Guanoxabenz. |
| Tolonidine | Xylazine may decrease the antihypertensive activities of Tolonidine. |
| Endralazine | Xylazine may decrease the antihypertensive activities of Endralazine. |
| Cadralazine | Xylazine may decrease the antihypertensive activities of Cadralazine. |
| Cyclopenthiazide | Xylazine may decrease the antihypertensive activities of Cyclopenthiazide. |
| Bietaserpine | Xylazine may decrease the antihypertensive activities of Bietaserpine. |
| Guanazodine | Xylazine may decrease the antihypertensive activities of Guanazodine. |
| Methoserpidine | Xylazine may decrease the antihypertensive activities of Methoserpidine. |
| Guanoclor | Xylazine may decrease the antihypertensive activities of Guanoclor. |
| Muzolimine | Xylazine may decrease the antihypertensive activities of Muzolimine. |
| Xipamide | Xylazine may decrease the antihypertensive activities of Xipamide. |
| Candesartan | Xylazine may decrease the antihypertensive activities of Candesartan. |
| Dexniguldipine | Xylazine may decrease the antihypertensive activities of Dexniguldipine. |