Tylosin

DB11475

small molecule vet_approved

Deskripsi

Tylosin is a bacteriostatic macrolide antibiotic and feed additive used in veterinary medicine. It has a broad spectrum of activity against Gram-positive organisms and a limited range of Gram-negative organisms. Tylosin is produced as a fermentation product of Streptomyces fradiae.

Struktur Molekul 2D

Berat 916.1001
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

173 Data
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Tylosin.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Tylosin.
Buspirone The metabolism of Buspirone can be decreased when combined with Tylosin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Tylosin.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Tylosin.
Disopyramide Tylosin may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Tylosin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Tylosin.
Quinine The serum concentration of Quinine can be increased when it is combined with Tylosin.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Tylosin.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Tylosin.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Tylosin.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tylosin.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Tylosin.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Tylosin.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Tylosin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tylosin.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Tylosin.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Tylosin.
Vindesine The serum concentration of Vindesine can be increased when it is combined with Tylosin.
Vinorelbine The serum concentration of Vinorelbine can be increased when it is combined with Tylosin.
Vincristine The serum concentration of Vincristine can be increased when it is combined with Tylosin.
Vinblastine The serum concentration of Vinblastine can be increased when it is combined with Tylosin.
Vinflunine The serum concentration of Vinflunine can be increased when it is combined with Tylosin.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Tylosin.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Tylosin.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Tylosin.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Tylosin.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Tylosin.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Tylosin.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Tylosin.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Tylosin.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Tylosin.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Tylosin.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Tylosin.
Digitoxin The serum concentration of Digitoxin can be increased when it is combined with Tylosin.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Tylosin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Tylosin.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Tylosin.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Tylosin.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Tylosin.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Tylosin.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Tylosin.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Tylosin.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Tylosin.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Tylosin.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Tylosin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Tylosin.
Phenprocoumon The serum concentration of Phenprocoumon can be increased when it is combined with Tylosin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Tylosin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Tylosin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Tylosin.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Tylosin.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Tylosin.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Tylosin.
Acefylline The metabolism of Acefylline can be decreased when combined with Tylosin.
Bufylline The metabolism of Bufylline can be decreased when combined with Tylosin.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Tylosin.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Tylosin.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Tylosin.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Tylosin.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Tylosin.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Tylosin.
Xanthine The metabolism of Xanthine can be decreased when combined with Tylosin.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Tylosin.
Guanine The metabolism of Guanine can be decreased when combined with Tylosin.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Tylosin.
Peldesine The metabolism of Peldesine can be decreased when combined with Tylosin.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Tylosin.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Tylosin.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Tylosin.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Tylosin.
Uric acid The metabolism of Uric acid can be decreased when combined with Tylosin.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Tylosin.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Tylosin.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Tylosin.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Tylosin.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Tylosin.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Tylosin.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Tylosin.
Furafylline The metabolism of Furafylline can be decreased when combined with Tylosin.
Theobromine The metabolism of Theobromine can be decreased when combined with Tylosin.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Tylosin.
Caffeine The metabolism of Caffeine can be decreased when combined with Tylosin.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Tylosin.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Tylosin.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Tylosin.
Theophylline The metabolism of Theophylline can be decreased when combined with Tylosin.
Aminophylline The metabolism of Aminophylline can be decreased when combined with Tylosin.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Tylosin.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Tylosin.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Tylosin.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Tylosin.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Tylosin.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Tylosin.
Lysergic acid diethylamide The serum concentration of Lysergic acid diethylamide can be increased when it is combined with Tylosin.
Dihydroergocornine The serum concentration of Dihydroergocornine can be increased when it is combined with Tylosin.
Dihydroergocristine The serum concentration of Dihydroergocristine can be increased when it is combined with Tylosin.
Dihydroergocryptine The serum concentration of Dihydroergocryptine can be increased when it is combined with Tylosin.
Terguride The serum concentration of Terguride can be increased when it is combined with Tylosin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 5891431
    Smith HW: Tylosin. Vet Rec. 1965 Nov 6;77(45):1342.
  • PMID: 6225619
    Verbov J: Tylosin dermatitis. Contact Dermatitis. 1983 Jul;9(4):325-6.
  • PMID: 5500229
    Morin RB, Gorman M, Hamill RL, Demarco PV: The structure of tylosin. Tetrahedron Lett. 1970 Nov;(54):4737-40.
  • PMID: 7649866
    Bobillot S, Bakos T, Sarda P, Thang TT, Ming L, Olesker A, Lukacs G: Chemical modification of tylosin. J Antibiot (Tokyo). 1995 Jul;48(7):667-70.
  • PMID: 6501102
    Omura S, Matsubara H, Tsuzuki K, Nakagawa A: Chemical modification of tylosin. Thioether derivatives of tylosin and demycarosyltylosin. J Antibiot (Tokyo). 1984 Sep;37(9):1007-15.
  • PMID: 812238
    Urbanova Z, Zahradnikova M, Schovanek V, Polak L, Rabas P, Sechser T, Svandova E, Raskova H, Raska K, Janovska D, Gutova M, Sverak V, Belinger A, Vanecek J, Zima L: Effect of tylosin in pigs. Vet Med (Praha). 1975 May;20(5):251-60.
  • PMID: 7292915
    Roberts R: Effect of feeding tylosin and tylosin and dimetridazole to cows. Vet Rec. 1981 May 16;108(20):446.
  • PMID: 7257138
    Crossman PJ, Poyser MR: Effect of feeding tylosin and tylosin with dimetridazole to cows. Vet Rec. 1981 May 30;108(22):483.
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