Tildipirosin

DB11470

small molecule vet_approved

Deskripsi

Tildipirosin is a veterinary antibiotic.

Struktur Molekul 2D

Berat 734.032
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

315 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Tildipirosin.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Tildipirosin.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Tildipirosin.
Buspirone The metabolism of Buspirone can be decreased when combined with Tildipirosin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Tildipirosin.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Tildipirosin.
Disopyramide Tildipirosin may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Tildipirosin.
Quinine The serum concentration of Quinine can be increased when it is combined with Tildipirosin.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Tildipirosin.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Tildipirosin.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Tildipirosin.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Tildipirosin.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Tildipirosin.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Tildipirosin.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Tildipirosin.
Colchicine The metabolism of Colchicine can be decreased when combined with Tildipirosin.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Tildipirosin.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Tildipirosin.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Tildipirosin.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Tildipirosin.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Tildipirosin.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Tildipirosin.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Tildipirosin.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Tildipirosin.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Tildipirosin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Tildipirosin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Tildipirosin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Tildipirosin.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Tildipirosin.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Tildipirosin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Tildipirosin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Tildipirosin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Tildipirosin.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Tildipirosin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Tildipirosin.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Tildipirosin.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Tildipirosin.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Tildipirosin.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Tildipirosin.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Tildipirosin.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Tildipirosin.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Tildipirosin.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Tildipirosin.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Tildipirosin.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Tildipirosin.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Tildipirosin.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Tildipirosin.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Tildipirosin.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Tildipirosin.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Tildipirosin.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Tildipirosin.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Tildipirosin.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Tildipirosin.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Tildipirosin.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Tildipirosin.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Tildipirosin.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Tildipirosin.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Tildipirosin.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Tildipirosin.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Tildipirosin.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Tildipirosin.
Acefylline The metabolism of Acefylline can be decreased when combined with Tildipirosin.
Bufylline The metabolism of Bufylline can be decreased when combined with Tildipirosin.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Tildipirosin.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Tildipirosin.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Tildipirosin.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Tildipirosin.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Tildipirosin.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Tildipirosin.
Xanthine The metabolism of Xanthine can be decreased when combined with Tildipirosin.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Tildipirosin.
Guanine The metabolism of Guanine can be decreased when combined with Tildipirosin.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Tildipirosin.
Peldesine The metabolism of Peldesine can be decreased when combined with Tildipirosin.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Tildipirosin.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Tildipirosin.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Tildipirosin.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Tildipirosin.
Uric acid The metabolism of Uric acid can be decreased when combined with Tildipirosin.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Tildipirosin.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Tildipirosin.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Tildipirosin.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Tildipirosin.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Tildipirosin.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Tildipirosin.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Tildipirosin.
Furafylline The metabolism of Furafylline can be decreased when combined with Tildipirosin.
Theobromine The metabolism of Theobromine can be decreased when combined with Tildipirosin.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Tildipirosin.
Caffeine The metabolism of Caffeine can be decreased when combined with Tildipirosin.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Tildipirosin.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Tildipirosin.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Tildipirosin.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Tildipirosin.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Tildipirosin.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Tildipirosin.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Tildipirosin.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Tildipirosin.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Tildipirosin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22188102
    Menge M, Rose M, Bohland C, Zschiesche E, Kilp S, Metz W, Allan M, Ropke R, Nurnberger M: Pharmacokinetics of tildipirosin in bovine plasma, lung tissue, and bronchial fluid (from live, nonanesthetized cattle). J Vet Pharmacol Ther. 2012 Dec;35(6):550-9. doi: 10.1111/j.1365-2885.2011.01349.x. Epub 2011 Dec 21.
  • PMID: 22926570
    Andersen NM, Poehlsgaard J, Warrass R, Douthwaite S: Inhibition of protein synthesis on the ribosome by tildipirosin compared with other veterinary macrolides. Antimicrob Agents Chemother. 2012 Nov;56(11):6033-6. doi: 10.1128/AAC.01250-12. Epub 2012 Aug 27.
  • PMID: 22563863
    Poehlsgaard J, Andersen NM, Warrass R, Douthwaite S: Visualizing the 16-membered ring macrolides tildipirosin and tilmicosin bound to their ribosomal site. ACS Chem Biol. 2012 Aug 17;7(8):1351-5. doi: 10.1021/cb300105p. Epub 2012 May 14.
  • PMID: 22398653
    Michael GB, Eidam C, Kadlec K, Meyer K, Sweeney MT, Murray RW, Watts JL, Schwarz S: Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm(42) and msr(E)-mph(E) for bovine Pasteurella multocida and Mannheimia haemolytica. J Antimicrob Chemother. 2012 Jun;67(6):1555-7. doi: 10.1093/jac/dks076. Epub 2012 Mar 7.
  • PMID: 22500881
    Rose M, Menge M, Bohland C, Zschiesche E, Wilhelm C, Kilp S, Metz W, Allan M, Ropke R, Nurnberger M: Pharmacokinetics of tildipirosin in porcine plasma, lung tissue, and bronchial fluid and effects of test conditions on in vitro activity against reference strains and field isolates of Actinobacillus pleuropneumoniae. J Vet Pharmacol Ther. 2013 Apr;36(2):140-53. doi: 10.1111/j.1365-2885.2012.01397.x. Epub 2012 Apr 15.
  • PMID: 24503775
    Gautier-Bouchardon AV, Ferre S, Le Grand D, Paoli A, Gay E, Poumarat F: Overall decrease in the susceptibility of Mycoplasma bovis to antimicrobials over the past 30 years in France. PLoS One. 2014 Feb 4;9(2):e87672. doi: 10.1371/journal.pone.0087672. eCollection 2014.
  • PMID: 26538405
    Rose M, Pridmore A, Shaw A, Wilhelm C, Menge M, Kilp S, Ropke R, Nurnberger M: A microbiological assay to estimate the antimicrobial activity of parenteral tildipirosin against foodborne pathogens and commensals in the colon of beef cattle and pigs. J Vet Pharmacol Ther. 2016 Jun;39(3):277-86. doi: 10.1111/jvp.12277. Epub 2015 Nov 5.
  • PMID: 25413993
    Dieste-Perez L, Fraile L, de Miguel MJ, Barberan M, Blasco JM, Munoz PM: Studies on a suitable antibiotic therapy for treating swine brucellosis. J Vet Pharmacol Ther. 2015 Aug;38(4):357-64. doi: 10.1111/jvp.12189. Epub 2014 Nov 21.
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