Selamectin

DB11459

small molecule vet_approved

Deskripsi

Selamectin is a topical parasiticide and antihelminthic used on dogs and cats to treat and prevent infections of heartworms, fleas, ear mites, sarcoptic mange, and certain types of ticks in dogs as well as prevent heartworms, fleas, ear mites, hookworms, and roundworms in cats. It also removes 2 types of lungworm in cats and one type of lungworm in dogs. It is distributed by Zoetis, a former Pfizer subsidiary. It is structurally related to ivermectin and milbemycin. Selamectin is not approved for human use.

Struktur Molekul 2D

Berat 769.973
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

315 Data
Eliglustat The metabolism of Eliglustat can be decreased when combined with Selamectin.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Selamectin.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Selamectin.
Buspirone The metabolism of Buspirone can be decreased when combined with Selamectin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Selamectin.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Selamectin.
Disopyramide Selamectin may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Selamectin.
Quinine The serum concentration of Quinine can be increased when it is combined with Selamectin.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Selamectin.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Selamectin.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Selamectin.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Selamectin.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Selamectin.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Selamectin.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Selamectin.
Colchicine The metabolism of Colchicine can be decreased when combined with Selamectin.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Selamectin.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Selamectin.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Selamectin.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Selamectin.
Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Selamectin.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Selamectin.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Selamectin.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Selamectin.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Selamectin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Selamectin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Selamectin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Selamectin.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Selamectin.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Selamectin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Selamectin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Selamectin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Selamectin.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Selamectin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Selamectin.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Selamectin.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Selamectin.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Selamectin.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Selamectin.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Selamectin.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Selamectin.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Selamectin.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Selamectin.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Selamectin.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Selamectin.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Selamectin.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Selamectin.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Selamectin.
Cyclosporine The metabolism of Cyclosporine can be decreased when combined with Selamectin.
Dicoumarol The serum concentration of Dicoumarol can be increased when it is combined with Selamectin.
Phenindione The serum concentration of Phenindione can be increased when it is combined with Selamectin.
Coumarin The serum concentration of Coumarin can be increased when it is combined with Selamectin.
Tioclomarol The serum concentration of Tioclomarol can be increased when it is combined with Selamectin.
Ethyl biscoumacetate The serum concentration of Ethyl biscoumacetate can be increased when it is combined with Selamectin.
Diphenadione The serum concentration of Diphenadione can be increased when it is combined with Selamectin.
4-hydroxycoumarin The serum concentration of 4-hydroxycoumarin can be increased when it is combined with Selamectin.
Fluindione The serum concentration of Fluindione can be increased when it is combined with Selamectin.
Clorindione The serum concentration of Clorindione can be increased when it is combined with Selamectin.
Oxtriphylline The metabolism of Oxtriphylline can be decreased when combined with Selamectin.
Doxofylline The metabolism of Doxofylline can be decreased when combined with Selamectin.
Bamifylline The metabolism of Bamifylline can be decreased when combined with Selamectin.
Acefylline The metabolism of Acefylline can be decreased when combined with Selamectin.
Bufylline The metabolism of Bufylline can be decreased when combined with Selamectin.
Fenethylline The metabolism of Fenethylline can be decreased when combined with Selamectin.
Proxyphylline The metabolism of Proxyphylline can be decreased when combined with Selamectin.
Bromotheophylline The metabolism of Bromotheophylline can be decreased when combined with Selamectin.
Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Selamectin.
8-azaguanine The metabolism of 8-azaguanine can be decreased when combined with Selamectin.
7,9-Dimethylguanine The metabolism of 7,9-Dimethylguanine can be decreased when combined with Selamectin.
Xanthine The metabolism of Xanthine can be decreased when combined with Selamectin.
7-Deazaguanine The metabolism of 7-Deazaguanine can be decreased when combined with Selamectin.
Guanine The metabolism of Guanine can be decreased when combined with Selamectin.
9-Methylguanine The metabolism of 9-Methylguanine can be decreased when combined with Selamectin.
Peldesine The metabolism of Peldesine can be decreased when combined with Selamectin.
Hypoxanthine The metabolism of Hypoxanthine can be decreased when combined with Selamectin.
9-Deazaguanine The metabolism of 9-Deazaguanine can be decreased when combined with Selamectin.
Valomaciclovir The metabolism of Valomaciclovir can be decreased when combined with Selamectin.
3-isobutyl-1-methyl-7H-xanthine The metabolism of 3-isobutyl-1-methyl-7H-xanthine can be decreased when combined with Selamectin.
Uric acid The metabolism of Uric acid can be decreased when combined with Selamectin.
6-O-benzylguanine The metabolism of 6-O-benzylguanine can be decreased when combined with Selamectin.
Lisofylline The metabolism of Lisofylline can be decreased when combined with Selamectin.
Lobucavir The metabolism of Lobucavir can be decreased when combined with Selamectin.
Cafedrine The metabolism of Cafedrine can be decreased when combined with Selamectin.
Theodrenaline The metabolism of Theodrenaline can be decreased when combined with Selamectin.
Etamiphylline The metabolism of Etamiphylline can be decreased when combined with Selamectin.
Pentifylline The metabolism of Pentifylline can be decreased when combined with Selamectin.
Furafylline The metabolism of Furafylline can be decreased when combined with Selamectin.
Theobromine The metabolism of Theobromine can be decreased when combined with Selamectin.
Propentofylline The metabolism of Propentofylline can be decreased when combined with Selamectin.
Caffeine The metabolism of Caffeine can be decreased when combined with Selamectin.
8-chlorotheophylline The metabolism of 8-chlorotheophylline can be decreased when combined with Selamectin.
Mercaptopurine The metabolism of Mercaptopurine can be decreased when combined with Selamectin.
PCS-499 The metabolism of PCS-499 can be decreased when combined with Selamectin.
Methylergometrine The serum concentration of Methylergometrine can be increased when it is combined with Selamectin.
Lisuride The serum concentration of Lisuride can be increased when it is combined with Selamectin.
Nicergoline The serum concentration of Nicergoline can be increased when it is combined with Selamectin.
Ergoloid mesylate The serum concentration of Ergoloid mesylate can be increased when it is combined with Selamectin.
Pergolide The serum concentration of Pergolide can be increased when it is combined with Selamectin.
Ergometrine The serum concentration of Ergometrine can be increased when it is combined with Selamectin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 10940537
    Krautmann MJ, Novotny MJ, De Keulenaer K, Godin CS, Evans EI, McCall JW, Wang C, Rowan TG, Jernigan AD: Safety of selamectin in cats. Vet Parasitol. 2000 Aug 23;91(3-4):393-403.
  • PMID: 10940536
    Novotny MJ, Krautmann MJ, Ehrhart JC, Godin CS, Evans EI, McCall JW, Sun F, Rowan TG, Jernigan AD: Safety of selamectin in dogs. Vet Parasitol. 2000 Aug 23;91(3-4):377-91.
  • PMID: 20021097
    Gupta RC, Masthay MB, Canerdy TD, Acosta TM, Provost RJ, Britton DM, Atieh BH, Keller RJ: Human exposure to selamectin from dogs treated with revolution: methodological consideration for selamectin isolation. Toxicol Mech Methods. 2005;15(4):317-21. doi: 10.1080/15376520590968860.
  • PMID: 10940518
    Jacobs DE: Selamectin - a novel endectocide for dogs and cats. Vet Parasitol. 2000 Aug 23;91(3-4):161-2.
  • PMID: 12625538
    Shanks DJ, Gautier P, McTier TL, Evans NA, Pengo G, Rowan TG: Efficacy of selamectin against biting lice on dogs and cats. Vet Rec. 2003 Feb 22;152(8):234-7.
  • PMID: 10940519
    Bishop BF, Bruce CI, Evans NA, Goudie AC, Gration KA, Gibson SP, Pacey MS, Perry DA, Walshe ND, Witty MJ: Selamectin: a novel broad-spectrum endectocide for dogs and cats. Vet Parasitol. 2000 Aug 23;91(3-4):163-76.
  • PMID: 20525946
    Schnabl B, Bettenay S, Glos N, Linek M, Loewenstein C, Mueller RS: Oral selamectin in the treatment of canine generalised demodicosis. Vet Rec. 2010 Jun 5;166(23):710-4. doi: 10.1136/vr.4850.
  • PMID: 15379435
    Dupuy J, Derlon AL, Sutra JF, Cadiergues MC, Franc M, Alvinerie M: Pharmacokinetics of selamectin in dogs after topical application. Vet Res Commun. 2004 Jul;28(5):407-13.
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