Roxarsone

DB11458

small molecule vet_approved

Deskripsi

Roxarsone is an organoarsenic molecule added to poultry feed. The addition of this compound to poultry feed improves weight gain and feed efficiency as well as prevent the growth of coccidian parasites. The drug is also approved in the United States for use in pigs.

Struktur Molekul 2D

Berat 263.0365
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

55 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Roxarsone.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Roxarsone.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Roxarsone.
Dicoumarol The risk or severity of bleeding can be increased when Roxarsone is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Roxarsone is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Roxarsone is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Roxarsone is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Roxarsone is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Roxarsone is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Roxarsone is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Roxarsone is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Roxarsone is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Roxarsone is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Roxarsone is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Roxarsone is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Roxarsone is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Roxarsone is combined with (S)-Warfarin.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Roxarsone.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Roxarsone.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Roxarsone.
Lidocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Quinisocaine.
Cisatracurium Roxarsone may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Roxarsone is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Roxarsone.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 12526912
    Bednar AJ, Garbarino JR, Ferrer I, Rutherford DW, Wershaw RL, Ranville JF, Wildeman TR: Photodegradation of roxarsone in poultry litter leachates. Sci Total Environ. 2003 Jan 20;302(1-3):237-45.
  • PMID: 12731831
    Garbarino JR, Bednar AJ, Rutherford DW, Beyer RS, Wershaw RL: Environmental fate of roxarsone in poultry litter. I. Degradation of roxarsone during composting. Environ Sci Technol. 2003 Apr 15;37(8):1509-14.
  • PMID: 20099042
    Andra SS, Makris KC, Quazi S, Sarkar D, Datta R, Bach SB: Organocopper complexes during roxarsone degradation in wastewater lagoons. Environ Sci Pollut Res Int. 2010 Jun;17(5):1167-73. doi: 10.1007/s11356-009-0281-7. Epub 2010 Jan 23.
  • PMID: 23498058
    Guo Q, Liu L, Hu Z, Chen G: Biological phosphorus removal inhibition by roxarsone in batch culture systems. Chemosphere. 2013 Jun;92(1):138-42. doi: 10.1016/j.chemosphere.2013.02.029. Epub 2013 Mar 14.
  • PMID: 16719096
    Cortinas I, Field JA, Kopplin M, Garbarino JR, Gandolfi AJ, Sierra-Alvarez R: Anaerobic biotransformation of roxarsone and related N-substituted phenylarsonic acids. Environ Sci Technol. 2006 May 1;40(9):2951-7.
  • PMID: 12724787
    Authors unspecified: NTP Toxicology and Carcinogenesis Studies of Roxarsone (CAS No. 121-19-7) in F344/N Rats and B6C3F1 Mice (Feed Studies). Natl Toxicol Program Tech Rep Ser. 1989 Mar;345:1-198.
  • PMID: 12731832
    Rutherford DW, Bednar AJ, Garbarino JR, Needham R, Staver KW, Wershaw RL: Environmental fate of roxarsone in poultry litter. Part II. Mobility of arsenic in soils amended with poultry litter. Environ Sci Technol. 2003 Apr 15;37(8):1515-20.
  • PMID: 18414637
    Basu P, Ghosh RN, Grove LE, Klei L, Barchowsky A: Angiogenic potential of 3-nitro-4-hydroxy benzene arsonic acid (roxarsone). Environ Health Perspect. 2008 Apr;116(4):520-3. doi: 10.1289/ehp.10885.
Menampilkan 8 dari 14 artikel.
Textbook
  • ISBN: 1584884169
    Yannai, Shmuel (2003). Dictionary of Food Compounds with : Additives, Flavors, and Ingredients. CRC Press LLC.

Contoh Produk & Brand

Produk: 0 • International brands: 2
International Brands
  • 3-Nitro
  • Ren-O-Sal

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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