Robenacoxib

DB11455

small molecule experimental vet_approved

Deskripsi

Robenacoxib is a non-steroidal anti-inflammatory drug used in veterinary medicine for the relief of pain and inflammation in cats and dogs.

Struktur Molekul 2D

Berat 327.279
Wujud -

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1404 Data
Amlodipine Robenacoxib may decrease the antihypertensive activities of Amlodipine.
Phentermine The risk or severity of hypertension can be increased when Phentermine is combined with Robenacoxib.
Midodrine The risk or severity of hypertension can be increased when Midodrine is combined with Robenacoxib.
Eletriptan The risk or severity of hypertension can be increased when Eletriptan is combined with Robenacoxib.
Isoetharine The risk or severity of hypertension can be increased when Isoetharine is combined with Robenacoxib.
Ziprasidone The risk or severity of hypertension can be increased when Ziprasidone is combined with Robenacoxib.
Methysergide The risk or severity of hypertension can be increased when Methysergide is combined with Robenacoxib.
Cabergoline The risk or severity of hypertension can be increased when Cabergoline is combined with Robenacoxib.
Zolmitriptan The risk or severity of hypertension can be increased when Zolmitriptan is combined with Robenacoxib.
Dihydroergotamine The risk or severity of hypertension can be increased when Dihydroergotamine is combined with Robenacoxib.
Methylergometrine The risk or severity of hypertension can be increased when Methylergometrine is combined with Robenacoxib.
Norepinephrine The risk or severity of hypertension can be increased when Norepinephrine is combined with Robenacoxib.
Mirtazapine The risk or severity of hypertension can be increased when Mirtazapine is combined with Robenacoxib.
Phenylephrine The risk or severity of hypertension can be increased when Phenylephrine is combined with Robenacoxib.
Phenylpropanolamine The risk or severity of hypertension can be increased when Phenylpropanolamine is combined with Robenacoxib.
Promazine The risk or severity of hypertension can be increased when Promazine is combined with Robenacoxib.
Droperidol The risk or severity of hypertension can be increased when Droperidol is combined with Robenacoxib.
Doxapram The risk or severity of hypertension can be increased when Doxapram is combined with Robenacoxib.
Atropine The risk or severity of hypertension can be increased when Atropine is combined with Robenacoxib.
Lisuride The risk or severity of hypertension can be increased when Lisuride is combined with Robenacoxib.
Linezolid The risk or severity of hypertension can be increased when Linezolid is combined with Robenacoxib.
Metaraminol The risk or severity of hypertension can be increased when Metaraminol is combined with Robenacoxib.
Furazolidone The risk or severity of hypertension can be increased when Furazolidone is combined with Robenacoxib.
Epinephrine The risk or severity of hypertension can be increased when Epinephrine is combined with Robenacoxib.
Thioridazine The risk or severity of hypertension can be increased when Thioridazine is combined with Robenacoxib.
Ergotamine The risk or severity of hypertension can be increased when Ergotamine is combined with Robenacoxib.
Nicergoline The risk or severity of hypertension can be increased when Nicergoline is combined with Robenacoxib.
Sufentanil The risk or severity of hypertension can be increased when Sufentanil is combined with Robenacoxib.
Methoxamine The risk or severity of hypertension can be increased when Methoxamine is combined with Robenacoxib.
Risperidone The risk or severity of hypertension can be increased when Risperidone is combined with Robenacoxib.
Tranylcypromine The risk or severity of hypertension can be increased when Tranylcypromine is combined with Robenacoxib.
Isoflurane The risk or severity of hypertension can be increased when Isoflurane is combined with Robenacoxib.
Propiomazine The risk or severity of hypertension can be increased when Propiomazine is combined with Robenacoxib.
Alfentanil The risk or severity of hypertension can be increased when Alfentanil is combined with Robenacoxib.
Minaprine The risk or severity of hypertension can be increased when Minaprine is combined with Robenacoxib.
Orciprenaline The risk or severity of hypertension can be increased when Orciprenaline is combined with Robenacoxib.
Propofol The risk or severity of hypertension can be increased when Propofol is combined with Robenacoxib.
Phenmetrazine The risk or severity of hypertension can be increased when Phenmetrazine is combined with Robenacoxib.
Trifluoperazine The risk or severity of hypertension can be increased when Trifluoperazine is combined with Robenacoxib.
Pseudoephedrine The risk or severity of hypertension can be increased when Pseudoephedrine is combined with Robenacoxib.
Benzphetamine The risk or severity of hypertension can be increased when Benzphetamine is combined with Robenacoxib.
Ritodrine The risk or severity of hypertension can be increased when Ritodrine is combined with Robenacoxib.
Flupentixol The risk or severity of hypertension can be increased when Flupentixol is combined with Robenacoxib.
Remifentanil The risk or severity of hypertension can be increased when Remifentanil is combined with Robenacoxib.
Bitolterol The risk or severity of hypertension can be increased when Bitolterol is combined with Robenacoxib.
Oxymetazoline The risk or severity of hypertension can be increased when Oxymetazoline is combined with Robenacoxib.
Diethylpropion The risk or severity of hypertension can be increased when Diethylpropion is combined with Robenacoxib.
Salmeterol The risk or severity of hypertension can be increased when Salmeterol is combined with Robenacoxib.
Naratriptan The risk or severity of hypertension can be increased when Naratriptan is combined with Robenacoxib.
Formoterol The risk or severity of hypertension can be increased when Formoterol is combined with Robenacoxib.
Frovatriptan The risk or severity of hypertension can be increased when Frovatriptan is combined with Robenacoxib.
Methoxyflurane The risk or severity of hypertension can be increased when Methoxyflurane is combined with Robenacoxib.
Selegiline The risk or severity of hypertension can be increased when Selegiline is combined with Robenacoxib.
Ergoloid mesylate The risk or severity of hypertension can be increased when Ergoloid mesylate is combined with Robenacoxib.
Isoprenaline The risk or severity of hypertension can be increased when Isoprenaline is combined with Robenacoxib.
Arbutamine The risk or severity of hypertension can be increased when Arbutamine is combined with Robenacoxib.
Dutasteride The risk or severity of hypertension can be increased when Dutasteride is combined with Robenacoxib.
Halothane The risk or severity of hypertension can be increased when Halothane is combined with Robenacoxib.
Moclobemide The risk or severity of hypertension can be increased when Moclobemide is combined with Robenacoxib.
Pergolide The risk or severity of hypertension can be increased when Pergolide is combined with Robenacoxib.
Desflurane The risk or severity of hypertension can be increased when Desflurane is combined with Robenacoxib.
Bromocriptine The risk or severity of hypertension can be increased when Bromocriptine is combined with Robenacoxib.
Finasteride The risk or severity of hypertension can be increased when Finasteride is combined with Robenacoxib.
Aripiprazole The risk or severity of hypertension can be increased when Aripiprazole is combined with Robenacoxib.
Isocarboxazid The risk or severity of hypertension can be increased when Isocarboxazid is combined with Robenacoxib.
Ergometrine The risk or severity of hypertension can be increased when Ergometrine is combined with Robenacoxib.
Lisdexamfetamine The risk or severity of hypertension can be increased when Lisdexamfetamine is combined with Robenacoxib.
Fenoterol The risk or severity of hypertension can be increased when Fenoterol is combined with Robenacoxib.
Pirbuterol The risk or severity of hypertension can be increased when Pirbuterol is combined with Robenacoxib.
Ephedra sinica root The risk or severity of hypertension can be increased when Ephedra sinica root is combined with Robenacoxib.
Ephedrine The risk or severity of hypertension can be increased when Ephedrine is combined with Robenacoxib.
Mephentermine The risk or severity of hypertension can be increased when Mephentermine is combined with Robenacoxib.
Procaterol The risk or severity of hypertension can be increased when Procaterol is combined with Robenacoxib.
Yohimbine The risk or severity of hypertension can be increased when Yohimbine is combined with Robenacoxib.
Methotrimeprazine The risk or severity of hypertension can be increased when Methotrimeprazine is combined with Robenacoxib.
Clenbuterol The risk or severity of hypertension can be increased when Clenbuterol is combined with Robenacoxib.
Bambuterol The risk or severity of hypertension can be increased when Bambuterol is combined with Robenacoxib.
MMDA The risk or severity of hypertension can be increased when MMDA is combined with Robenacoxib.
Midomafetamine The risk or severity of hypertension can be increased when Midomafetamine is combined with Robenacoxib.
2,5-Dimethoxy-4-ethylamphetamine The risk or severity of hypertension can be increased when 2,5-Dimethoxy-4-ethylamphetamine is combined with Robenacoxib.
4-Methoxyamphetamine The risk or severity of hypertension can be increased when 4-Methoxyamphetamine is combined with Robenacoxib.
4-Bromo-2,5-dimethoxyamphetamine The risk or severity of hypertension can be increased when 4-Bromo-2,5-dimethoxyamphetamine is combined with Robenacoxib.
Tenamfetamine The risk or severity of hypertension can be increased when Tenamfetamine is combined with Robenacoxib.
Chlorphentermine The risk or severity of hypertension can be increased when Chlorphentermine is combined with Robenacoxib.
Dextroamphetamine The risk or severity of hypertension can be increased when Dextroamphetamine is combined with Robenacoxib.
Phendimetrazine The risk or severity of hypertension can be increased when Phendimetrazine is combined with Robenacoxib.
Solifenacin The risk or severity of hypertension can be increased when Solifenacin is combined with Robenacoxib.
Periciazine The risk or severity of hypertension can be increased when Periciazine is combined with Robenacoxib.
Acepromazine The risk or severity of hypertension can be increased when Acepromazine is combined with Robenacoxib.
Thioproperazine The risk or severity of hypertension can be increased when Thioproperazine is combined with Robenacoxib.
Zuclopenthixol The risk or severity of hypertension can be increased when Zuclopenthixol is combined with Robenacoxib.
Epicaptopril The risk or severity of hypertension can be increased when Epicaptopril is combined with Robenacoxib.
Clorgiline The risk or severity of hypertension can be increased when Clorgiline is combined with Robenacoxib.
1-benzylimidazole The risk or severity of hypertension can be increased when 1-benzylimidazole is combined with Robenacoxib.
Iproniazid The risk or severity of hypertension can be increased when Iproniazid is combined with Robenacoxib.
Nialamide The risk or severity of hypertension can be increased when Nialamide is combined with Robenacoxib.
Lysergic acid diethylamide The risk or severity of hypertension can be increased when Lysergic acid diethylamide is combined with Robenacoxib.
Dronedarone The risk or severity of hypertension can be increased when Dronedarone is combined with Robenacoxib.
Flibanserin The risk or severity of hypertension can be increased when Flibanserin is combined with Robenacoxib.
Iloperidone The risk or severity of hypertension can be increased when Iloperidone is combined with Robenacoxib.

Target Protein

Cyclooxygenase 2 PTGS2

Referensi & Sumber

Artikel (PubMed)
  • PMID: 21736587
    King JN, Hotz R, Reagan EL, Roth DR, Seewald W, Lees P: Safety of oral robenacoxib in the cat. J Vet Pharmacol Ther. 2012 Jun;35(3):290-300. doi: 10.1111/j.1365-2885.2011.01320.x. Epub 2011 Jul 8.
  • PMID: 19161454
    Jung M, Lees P, Seewald W, King JN: Analytical determination and pharmacokinetics of robenacoxib in the dog. J Vet Pharmacol Ther. 2009 Feb;32(1):41-8. doi: 10.1111/j.1365-2885.2008.01035.x.
  • PMID: 23434263
    Staffieri F, Centonze P, Gigante G, De Pietro L, Crovace A: Comparison of the analgesic effects of robenacoxib, buprenorphine and their combination in cats after ovariohysterectomy. Vet J. 2013 Aug;197(2):363-7. doi: 10.1016/j.tvjl.2013.01.018. Epub 2013 Feb 21.
  • PMID: 19161453
    Giraudel JM, Toutain PL, King JN, Lees P: Differential inhibition of cyclooxygenase isoenzymes in the cat by the NSAID robenacoxib. J Vet Pharmacol Ther. 2009 Feb;32(1):31-40. doi: 10.1111/j.1365-2885.2008.01031.x.
  • PMID: 20004922
    King JN, Rudaz C, Borer L, Jung M, Seewald W, Lees P: In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study. Res Vet Sci. 2010 Jun;88(3):497-506. doi: 10.1016/j.rvsc.2009.11.002. Epub 2009 Dec 11.
  • PMID: 21480932
    Reymond N, Speranza C, Gruet P, Seewald W, King JN: Robenacoxib vs. carprofen for the treatment of canine osteoarthritis; a randomized, noninferiority clinical trial. J Vet Pharmacol Ther. 2012 Apr;35(2):175-83. doi: 10.1111/j.1365-2885.2011.01297.x. Epub 2011 Apr 12.
  • PMID: 21767277
    Pelligand L, King JN, Toutain PL, Elliott J, Lees P: Pharmacokinetic/pharmacodynamic modelling of robenacoxib in a feline tissue cage model of inflammation. J Vet Pharmacol Ther. 2012 Feb;35(1):19-32. doi: 10.1111/j.1365-2885.2011.01288.x. Epub 2011 Jul 18.
  • PMID: 23438125
    King JN, Jung M, Maurer MP, Schmid VB, Seewald W, Lees P: Effects of route of administration and feeding schedule on pharmacokinetics of robenacoxib in cats. Am J Vet Res. 2013 Mar;74(3):465-72. doi: 10.2460/ajvr.74.3.465.
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Sekuens Gen/Protein (FASTA)

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