Phenothiazine

DB11447

small molecule experimental vet_approved

Deskripsi

Phenothiazine (PTZ) is an organic thiazine compound.

Struktur Molekul 2D

Berat 199.27
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

92 Data
Lorazepam The therapeutic efficacy of Lorazepam can be decreased when used in combination with Phenothiazine.
Pregabalin The therapeutic efficacy of Pregabalin can be decreased when used in combination with Phenothiazine.
Butalbital The therapeutic efficacy of Butalbital can be decreased when used in combination with Phenothiazine.
Pentobarbital The therapeutic efficacy of Pentobarbital can be decreased when used in combination with Phenothiazine.
Valproic acid The therapeutic efficacy of Valproic acid can be decreased when used in combination with Phenothiazine.
Trimethadione The therapeutic efficacy of Trimethadione can be decreased when used in combination with Phenothiazine.
Secobarbital The therapeutic efficacy of Secobarbital can be decreased when used in combination with Phenothiazine.
Metharbital The therapeutic efficacy of Metharbital can be decreased when used in combination with Phenothiazine.
Methohexital The therapeutic efficacy of Methohexital can be decreased when used in combination with Phenothiazine.
Mephenytoin The therapeutic efficacy of Mephenytoin can be decreased when used in combination with Phenothiazine.
Ethosuximide The therapeutic efficacy of Ethosuximide can be decreased when used in combination with Phenothiazine.
Thiopental The therapeutic efficacy of Thiopental can be decreased when used in combination with Phenothiazine.
Paramethadione The therapeutic efficacy of Paramethadione can be decreased when used in combination with Phenothiazine.
Clorazepic acid The therapeutic efficacy of Clorazepic acid can be decreased when used in combination with Phenothiazine.
Magnesium sulfate The therapeutic efficacy of Magnesium sulfate can be decreased when used in combination with Phenothiazine.
Tizanidine The therapeutic efficacy of Tizanidine can be decreased when used in combination with Phenothiazine.
Riluzole The therapeutic efficacy of Riluzole can be decreased when used in combination with Phenothiazine.
Ethotoin The therapeutic efficacy of Ethotoin can be decreased when used in combination with Phenothiazine.
Primidone The therapeutic efficacy of Primidone can be decreased when used in combination with Phenothiazine.
Acetazolamide The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Phenothiazine.
Phensuximide The therapeutic efficacy of Phensuximide can be decreased when used in combination with Phenothiazine.
Progabide The therapeutic efficacy of Progabide can be decreased when used in combination with Phenothiazine.
Methylphenobarbital The therapeutic efficacy of Methylphenobarbital can be decreased when used in combination with Phenothiazine.
Tiagabine The therapeutic efficacy of Tiagabine can be decreased when used in combination with Phenothiazine.
Felbamate The therapeutic efficacy of Felbamate can be decreased when used in combination with Phenothiazine.
Zaleplon The therapeutic efficacy of Zaleplon can be decreased when used in combination with Phenothiazine.
Gabapentin The therapeutic efficacy of Gabapentin can be decreased when used in combination with Phenothiazine.
Clonazepam The therapeutic efficacy of Clonazepam can be decreased when used in combination with Phenothiazine.
Vigabatrin The therapeutic efficacy of Vigabatrin can be decreased when used in combination with Phenothiazine.
Phenacemide The therapeutic efficacy of Phenacemide can be decreased when used in combination with Phenothiazine.
Thiamylal The therapeutic efficacy of Thiamylal can be decreased when used in combination with Phenothiazine.
Estazolam The therapeutic efficacy of Estazolam can be decreased when used in combination with Phenothiazine.
Fosphenytoin The therapeutic efficacy of Fosphenytoin can be decreased when used in combination with Phenothiazine.
Amobarbital The therapeutic efficacy of Amobarbital can be decreased when used in combination with Phenothiazine.
Hexobarbital The therapeutic efficacy of Hexobarbital can be decreased when used in combination with Phenothiazine.
Barbital The therapeutic efficacy of Barbital can be decreased when used in combination with Phenothiazine.
Delorazepam The therapeutic efficacy of Delorazepam can be decreased when used in combination with Phenothiazine.
Nitrazepam The therapeutic efficacy of Nitrazepam can be decreased when used in combination with Phenothiazine.
7-Nitroindazole The therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Phenothiazine.
Valpromide The therapeutic efficacy of Valpromide can be decreased when used in combination with Phenothiazine.
Flunarizine The therapeutic efficacy of Flunarizine can be decreased when used in combination with Phenothiazine.
Ezogabine The therapeutic efficacy of Ezogabine can be decreased when used in combination with Phenothiazine.
Methsuximide The therapeutic efficacy of Methsuximide can be decreased when used in combination with Phenothiazine.
Brivaracetam The therapeutic efficacy of Brivaracetam can be decreased when used in combination with Phenothiazine.
Rufinamide The therapeutic efficacy of Rufinamide can be decreased when used in combination with Phenothiazine.
Lacosamide The therapeutic efficacy of Lacosamide can be decreased when used in combination with Phenothiazine.
Remacemide The therapeutic efficacy of Remacemide can be decreased when used in combination with Phenothiazine.
Clomethiazole The therapeutic efficacy of Clomethiazole can be decreased when used in combination with Phenothiazine.
Deramciclane The therapeutic efficacy of Deramciclane can be decreased when used in combination with Phenothiazine.
Tramiprosate The therapeutic efficacy of Tramiprosate can be decreased when used in combination with Phenothiazine.
Gaboxadol The therapeutic efficacy of Gaboxadol can be decreased when used in combination with Phenothiazine.
Sulthiame The therapeutic efficacy of Sulthiame can be decreased when used in combination with Phenothiazine.
Perampanel The therapeutic efficacy of Perampanel can be decreased when used in combination with Phenothiazine.
Ifenprodil The therapeutic efficacy of Ifenprodil can be decreased when used in combination with Phenothiazine.
Barbexaclone The therapeutic efficacy of Barbexaclone can be decreased when used in combination with Phenothiazine.
Beclamide The therapeutic efficacy of Beclamide can be decreased when used in combination with Phenothiazine.
Cannabidiol The therapeutic efficacy of Cannabidiol can be decreased when used in combination with Phenothiazine.
Paraldehyde The therapeutic efficacy of Paraldehyde can be decreased when used in combination with Phenothiazine.
Stiripentol The therapeutic efficacy of Stiripentol can be decreased when used in combination with Phenothiazine.
Eslicarbazepine acetate The therapeutic efficacy of Eslicarbazepine acetate can be decreased when used in combination with Phenothiazine.
Doramectin The therapeutic efficacy of Doramectin can be decreased when used in combination with Phenothiazine.
Tiletamine The therapeutic efficacy of Tiletamine can be decreased when used in combination with Phenothiazine.
Brexanolone The therapeutic efficacy of Brexanolone can be decreased when used in combination with Phenothiazine.
Etiracetam The therapeutic efficacy of Etiracetam can be decreased when used in combination with Phenothiazine.
Vinpocetine The therapeutic efficacy of Vinpocetine can be decreased when used in combination with Phenothiazine.
Carisbamate The therapeutic efficacy of Carisbamate can be decreased when used in combination with Phenothiazine.
Pheneturide The therapeutic efficacy of Pheneturide can be decreased when used in combination with Phenothiazine.
Neocitrullamon The therapeutic efficacy of Neocitrullamon can be decreased when used in combination with Phenothiazine.
Medazepam The therapeutic efficacy of Medazepam can be decreased when used in combination with Phenothiazine.
Phenibut The therapeutic efficacy of Phenibut can be decreased when used in combination with Phenothiazine.
Ethadione The therapeutic efficacy of Ethadione can be decreased when used in combination with Phenothiazine.
Cannabidivarin The therapeutic efficacy of Cannabidivarin can be decreased when used in combination with Phenothiazine.
Eslicarbazepine The therapeutic efficacy of Eslicarbazepine can be decreased when used in combination with Phenothiazine.
JNJ-26489112 The therapeutic efficacy of JNJ-26489112 can be decreased when used in combination with Phenothiazine.
Cenobamate The therapeutic efficacy of Cenobamate can be decreased when used in combination with Phenothiazine.
Phenytoin The therapeutic efficacy of Phenytoin can be decreased when used in combination with Phenothiazine.
Topiramate The therapeutic efficacy of Topiramate can be decreased when used in combination with Phenothiazine.
Clobazam The therapeutic efficacy of Clobazam can be decreased when used in combination with Phenothiazine.
Lamotrigine The therapeutic efficacy of Lamotrigine can be decreased when used in combination with Phenothiazine.
Carbamazepine The therapeutic efficacy of Carbamazepine can be decreased when used in combination with Phenothiazine.
Oxcarbazepine The therapeutic efficacy of Oxcarbazepine can be decreased when used in combination with Phenothiazine.
Diazepam The therapeutic efficacy of Diazepam can be decreased when used in combination with Phenothiazine.
Zonisamide The therapeutic efficacy of Zonisamide can be decreased when used in combination with Phenothiazine.
Phenobarbital The therapeutic efficacy of Phenobarbital can be decreased when used in combination with Phenothiazine.
Levetiracetam The therapeutic efficacy of Levetiracetam can be decreased when used in combination with Phenothiazine.
Amifampridine The risk or severity of seizure can be increased when Phenothiazine is combined with Amifampridine.
Dalfampridine The risk or severity of seizure can be increased when Phenothiazine is combined with Dalfampridine.
Bupropion The risk or severity of seizure can be increased when Bupropion is combined with Phenothiazine.
Amitriptyline The serum concentration of Nortriptyline, an active metabolite of Amitriptyline, can be decreased when used in combination with Phenothiazine.
Fenfluramine The therapeutic efficacy of Fenfluramine can be decreased when used in combination with Phenothiazine.
Ganaxolone The therapeutic efficacy of Ganaxolone can be decreased when used in combination with Phenothiazine.
Hydroxychloroquine The risk or severity of seizure can be increased when Hydroxychloroquine is combined with Phenothiazine.

Target Protein

Androgen receptor AR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 17647710
    Authors unspecified: Phenothiazine. Can J Comp Med Vet Sci. 1940 Dec;4(12):332.
  • PMID: 20285807
    Authors unspecified: PHENOTHIAZINE. Bull Am Pharm Assoc. 1946 Jul-Aug;14(7-8):158.
  • PMID: 5359756
    Boet DJ: Phenothiazine retinopathy. Ophthalmologica. 1969;158 Suppl:574-82.
  • PMID: 13474074
    RAPPAPORT R: Phenothiazine derivatives. Fr Med. 1957 Aug-Sep;20(8-9):23-6.
  • PMID: 5647013
    Alkemade PP: Phenothiazine-retinopathy. Ophthalmologica. 1968;155(1):70-6.
  • PMID: 14263549
    LONGMORE DB: PHENOTHIAZINE PIGMENTATION. Lancet. 1965 Apr 17;1(7390):854.
  • PMID: 14346775
    RICHARDS F: PHENOTHIAZINE PIGMENTATION. Lancet. 1965 Aug 28;2(7409):437.
  • PMID: 2889672
    Singh SD, Varma A: Phenothiazine poisoning. Indian Pediatr. 1986 Oct;23 Suppl:172-3.
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Sekuens Gen/Protein (FASTA)

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