Mibolerone

DB11429

small molecule vet_approved

Deskripsi

Mibolerone is a potent anabolic steroid which is both higher affinity and more selective for the androgen receptor than metribolone.

Struktur Molekul 2D

Berat 302.458
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

149 Data
Prasterone The serum concentration of Mibolerone can be increased when it is combined with Prasterone.
Dextrose, unspecified form The serum concentration of Dextrose, unspecified form can be decreased when it is combined with Mibolerone.
Propranolol Mibolerone may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Flunisolide The risk or severity of edema formation can be increased when Mibolerone is combined with Flunisolide.
Beclomethasone dipropionate The risk or severity of edema formation can be increased when Mibolerone is combined with Beclomethasone dipropionate.
Betamethasone The risk or severity of edema formation can be increased when Mibolerone is combined with Betamethasone.
Fluticasone propionate The risk or severity of edema formation can be increased when Mibolerone is combined with Fluticasone propionate.
Fluocinolone acetonide The risk or severity of edema formation can be increased when Mibolerone is combined with Fluocinolone acetonide.
Triamcinolone The risk or severity of edema formation can be increased when Mibolerone is combined with Triamcinolone.
Prednisone The risk or severity of edema formation can be increased when Mibolerone is combined with Prednisone.
Fludrocortisone The risk or severity of edema formation can be increased when Mibolerone is combined with Fludrocortisone.
Hydrocortisone The risk or severity of edema formation can be increased when Mibolerone is combined with Hydrocortisone.
Prednisolone The risk or severity of edema formation can be increased when Mibolerone is combined with Prednisolone.
Methylprednisolone The risk or severity of edema formation can be increased when Mibolerone is combined with Methylprednisolone.
Trilostane The risk or severity of edema formation can be increased when Mibolerone is combined with Trilostane.
Budesonide The risk or severity of edema formation can be increased when Mibolerone is combined with Budesonide.
Dexamethasone The risk or severity of edema formation can be increased when Mibolerone is combined with Dexamethasone.
Corticotropin The risk or severity of edema formation can be increased when Mibolerone is combined with Corticotropin.
Cortisone acetate The risk or severity of edema formation can be increased when Mibolerone is combined with Cortisone acetate.
Paramethasone The risk or severity of edema formation can be increased when Mibolerone is combined with Paramethasone.
Ciclesonide The risk or severity of edema formation can be increased when Mibolerone is combined with Ciclesonide.
Aldosterone The risk or severity of edema formation can be increased when Mibolerone is combined with Aldosterone.
Fluticasone furoate The risk or severity of edema formation can be increased when Mibolerone is combined with Fluticasone furoate.
Fluprednidene The risk or severity of edema formation can be increased when Mibolerone is combined with Fluprednidene.
Tixocortol The risk or severity of edema formation can be increased when Mibolerone is combined with Tixocortol.
Fluprednisolone The risk or severity of edema formation can be increased when Mibolerone is combined with Fluprednisolone.
Meprednisone The risk or severity of edema formation can be increased when Mibolerone is combined with Meprednisone.
Dexamethasone isonicotinate The risk or severity of edema formation can be increased when Mibolerone is combined with Dexamethasone isonicotinate.
Melengestrol The risk or severity of edema formation can be increased when Mibolerone is combined with Melengestrol.
Deflazacort The risk or severity of edema formation can be increased when Mibolerone is combined with Deflazacort.
Cortivazol The risk or severity of edema formation can be increased when Mibolerone is combined with Cortivazol.
Prednylidene The risk or severity of edema formation can be increased when Mibolerone is combined with Prednylidene.
Fluocortin The risk or severity of edema formation can be increased when Mibolerone is combined with Fluocortin.
Fluperolone The risk or severity of edema formation can be increased when Mibolerone is combined with Fluperolone.
Cloprednol The risk or severity of edema formation can be increased when Mibolerone is combined with Cloprednol.
Fluclorolone The risk or severity of edema formation can be increased when Mibolerone is combined with Fluclorolone.
Fluticasone The risk or severity of edema formation can be increased when Mibolerone is combined with Fluticasone.
Mometasone furoate The risk or severity of edema formation can be increased when Mibolerone is combined with Mometasone furoate.
Hydrocortisone acetate The risk or severity of edema formation can be increased when Mibolerone is combined with Hydrocortisone acetate.
Hydrocortisone cypionate The risk or severity of edema formation can be increased when Mibolerone is combined with Hydrocortisone cypionate.
Hydrocortisone succinate The risk or severity of edema formation can be increased when Mibolerone is combined with Hydrocortisone succinate.
Prednisolone phosphate The risk or severity of edema formation can be increased when Mibolerone is combined with Prednisolone phosphate.
Prednisolone hemisuccinate The risk or severity of edema formation can be increased when Mibolerone is combined with Prednisolone hemisuccinate.
Methylprednisolone hemisuccinate The risk or severity of edema formation can be increased when Mibolerone is combined with Methylprednisolone hemisuccinate.
Prednisone acetate The risk or severity of edema formation can be increased when Mibolerone is combined with Prednisone acetate.
Clocortolone acetate The risk or severity of edema formation can be increased when Mibolerone is combined with Clocortolone acetate.
Melengestrol acetate The risk or severity of edema formation can be increased when Mibolerone is combined with Melengestrol acetate.
Betamethasone phosphate The risk or severity of edema formation can be increased when Mibolerone is combined with Betamethasone phosphate.
Cortisone The risk or severity of edema formation can be increased when Mibolerone is combined with Cortisone.
Clobetasol propionate The risk or severity of edema formation can be increased when Mibolerone is combined with Clobetasol propionate.
Fluocinonide The risk or severity of edema formation can be increased when Mibolerone is combined with Fluocinonide.
Hydrocortisone butyrate The risk or severity of edema formation can be increased when Mibolerone is combined with Hydrocortisone butyrate.
Desoximetasone The risk or severity of edema formation can be increased when Mibolerone is combined with Desoximetasone.
Mometasone The risk or severity of edema formation can be increased when Mibolerone is combined with Mometasone.
Fluocortolone The risk or severity of edema formation can be increased when Mibolerone is combined with Fluocortolone.
Prednisolone acetate The risk or severity of edema formation can be increased when Mibolerone is combined with Prednisolone acetate.
Fluorometholone The risk or severity of edema formation can be increased when Mibolerone is combined with Fluorometholone.
Difluocortolone The risk or severity of edema formation can be increased when Mibolerone is combined with Difluocortolone.
Flumethasone The risk or severity of edema formation can be increased when Mibolerone is combined with Flumethasone.
Methylprednisolone aceponate The risk or severity of edema formation can be increased when Mibolerone is combined with Methylprednisolone aceponate.
Lepirudin Mibolerone may increase the anticoagulant activities of Lepirudin.
Bivalirudin Mibolerone may increase the anticoagulant activities of Bivalirudin.
Alteplase Mibolerone may increase the anticoagulant activities of Alteplase.
Urokinase Mibolerone may increase the anticoagulant activities of Urokinase.
Reteplase Mibolerone may increase the anticoagulant activities of Reteplase.
Anistreplase Mibolerone may increase the anticoagulant activities of Anistreplase.
Tenecteplase Mibolerone may increase the anticoagulant activities of Tenecteplase.
Abciximab Mibolerone may increase the anticoagulant activities of Abciximab.
Drotrecogin alfa Mibolerone may increase the anticoagulant activities of Drotrecogin alfa.
Streptokinase Mibolerone may increase the anticoagulant activities of Streptokinase.
Dicoumarol Mibolerone may increase the anticoagulant activities of Dicoumarol.
Argatroban Mibolerone may increase the anticoagulant activities of Argatroban.
Ardeparin Mibolerone may increase the anticoagulant activities of Ardeparin.
Phenindione Mibolerone may increase the anticoagulant activities of Phenindione.
Fondaparinux Mibolerone may increase the anticoagulant activities of Fondaparinux.
Warfarin Mibolerone may increase the anticoagulant activities of Warfarin.
Pentosan polysulfate Mibolerone may increase the anticoagulant activities of Pentosan polysulfate.
Phenprocoumon Mibolerone may increase the anticoagulant activities of Phenprocoumon.
Dipyridamole Mibolerone may increase the anticoagulant activities of Dipyridamole.
Heparin Mibolerone may increase the anticoagulant activities of Heparin.
Enoxaparin Mibolerone may increase the anticoagulant activities of Enoxaparin.
Epoprostenol Mibolerone may increase the anticoagulant activities of Epoprostenol.
Acenocoumarol Mibolerone may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Mibolerone may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Mibolerone may increase the anticoagulant activities of Coumarin.
Ximelagatran Mibolerone may increase the anticoagulant activities of Ximelagatran.
Desmoteplase Mibolerone may increase the anticoagulant activities of Desmoteplase.
Defibrotide Mibolerone may increase the anticoagulant activities of Defibrotide.
Ancrod Mibolerone may increase the anticoagulant activities of Ancrod.
Beraprost Mibolerone may increase the anticoagulant activities of Beraprost.
Prasugrel Mibolerone may increase the anticoagulant activities of Prasugrel.
Rivaroxaban Mibolerone may increase the anticoagulant activities of Rivaroxaban.
Sulodexide Mibolerone may increase the anticoagulant activities of Sulodexide.
Semuloparin Mibolerone may increase the anticoagulant activities of Semuloparin.
Idraparinux Mibolerone may increase the anticoagulant activities of Idraparinux.
Cangrelor Mibolerone may increase the anticoagulant activities of Cangrelor.
Astaxanthin Mibolerone may increase the anticoagulant activities of Astaxanthin.
Apixaban Mibolerone may increase the anticoagulant activities of Apixaban.
Otamixaban Mibolerone may increase the anticoagulant activities of Otamixaban.
Amediplase Mibolerone may increase the anticoagulant activities of Amediplase.

Target Protein

Androgen receptor AR

Referensi & Sumber

Artikel (PubMed)
  • PMID: 25955
    Amin MI, Koshy KT, Bryan JT: Stability of aqueous solutions of mibolerone. J Pharm Sci. 1976 Dec;65(12):1777-9.
  • PMID: 869826
    Kakuk TJ, Frank FR, Weddon TE: Avian lymphoid leukosis prophylaxis with mibolerone. Avian Dis. 1977 Apr-Jun;21(2):280-9.
  • PMID: 405963
    Romero CH, Purchase HG, Frank F, Burmester BR, Kakuk TJ, Chang TS: Immune responses of chickens fed the androgen analog mibolerone. Avian Dis. 1977 Apr-Jun;21(2):264-79.
  • PMID: 4070927
    Seaman WJ: Canine ovarian fibroma associated with prolonged exposure to mibolerone. Toxicol Pathol. 1985;13(3):177-80.
  • PMID: 4077632
    Gardner HM, Hueston WD, Donovan EF: Use of mibolerone in wolves and in three Panthera species. J Am Vet Med Assoc. 1985 Dec 1;187(11):1193-4.
  • PMID: 6254486
    Lucio B, Hitchner SB: Response of mibolerone-treated chickens to infectious bursal disease virus. Avian Dis. 1980 Apr-Jun;24(2):334-44.
  • PMID: 2422638
    Murthy LR, Johnson MP, Rowley DR, Young CY, Scardino PT, Tindall DJ: Characterization of steroid receptors in human prostate using mibolerone. Prostate. 1986;8(3):241-53.
  • PMID: 921032
    Sokolowski JH, Geng S: Biological evaluation of mibolerone in the female Beagle. Am J Vet Res. 1977 Sep;38(9):1371-6.
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