Marbofloxacin

DB11426

small molecule vet_approved

Deskripsi

Marbofloxacin is a carboxylic acid, part of the third generation of antibiotic fluoroquinolones. It is used in veterinary medicine. A formulation of marbofloxacin combined with clotrimazole and dexamethasone is available under the name Aurizon.

Struktur Molekul 2D

Berat 362.361
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

55 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Marbofloxacin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Marbofloxacin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Marbofloxacin.
Dicoumarol The risk or severity of bleeding can be increased when Marbofloxacin is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Marbofloxacin is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Marbofloxacin is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Marbofloxacin is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Marbofloxacin is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Marbofloxacin is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Marbofloxacin is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Marbofloxacin is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Marbofloxacin is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Marbofloxacin is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Marbofloxacin is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Marbofloxacin is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Marbofloxacin is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Marbofloxacin is combined with (S)-Warfarin.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Marbofloxacin.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Marbofloxacin.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Marbofloxacin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Quinisocaine.
Cisatracurium Marbofloxacin may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Marbofloxacin is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Marbofloxacin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22590047
    Shen J, Qian JJ, Gu JM, Hu XR: Marbofloxacin. Acta Crystallogr Sect E Struct Rep Online. 2012 Apr 1;68(Pt 4):o998-9. doi: 10.1107/S1600536812009312. Epub 2012 Mar 10.
  • PMID: 12117108
    Bousquet-Melou A, Bernard S, Schneider M, Toutain PL: Pharmacokinetics of marbofloxacin in horses. Equine Vet J. 2002 Jul;34(4):366-72.
  • PMID: 23375665
    Illambas J, Potter T, Cheng Z, Rycroft A, Fishwick J, Lees P: Pharmacodynamics of marbofloxacin for calf pneumonia pathogens. Res Vet Sci. 2013 Jun;94(3):675-81. doi: 10.1016/j.rvsc.2012.12.012. Epub 2013 Jan 31.
  • PMID: 12118670
    Anadon A, Martinez-Larranaga MR, Diaz MJ, Martinez MA, Frejo MT, Martinez M, Tafur M, Castellano VJ: Pharmacokinetic characteristics and tissue residues for marbofloxacin and its metabolite N-desmethyl-marbofloxacin in broiler chickens. Am J Vet Res. 2002 Jul;63(7):927-33.
  • PMID: 15500564
    Peyrou M, Doucet MY, Vrins A, Concordet D, Schneider M, Bousquet-Melou A: Population pharmacokinetics of marbofloxacin in horses: preliminary analysis. J Vet Pharmacol Ther. 2004 Oct;27(5):283-8.
  • PMID: 9652038
    Lefebvre HP, Dupouy V, Schneider M, Laroute V, Toutain PL: Pharmacokinetics of marbofloxacin in renal impairment in the dog. Vet Q. 1998;20 Suppl 1:S104.
  • PMID: 16940071
    Haritova AM, Rusenova NV, Parvanov PR, Lashev LD, Fink-Gremmels J: Integration of pharmacokinetic and pharmacodynamic indices of marbofloxacin in turkeys. Antimicrob Agents Chemother. 2006 Nov;50(11):3779-85. Epub 2006 Aug 28.
  • PMID: 16740085
    Carpenter JW, Hunter RP, Olsen JH, Henry H, Isaza R, Koch DE: Pharmacokinetics of marbofloxacin in blue and gold macaws (Ara ararauna). Am J Vet Res. 2006 Jun;67(6):947-50.
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