Gamithromycin

DB11416

small molecule vet_approved

Deskripsi

Gamithromycin is an antibiotic used in cattle.

Struktur Molekul 2D

Berat 777.05
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

55 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Gamithromycin.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Gamithromycin.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Gamithromycin.
Dicoumarol The risk or severity of bleeding can be increased when Gamithromycin is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Gamithromycin is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Gamithromycin is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Gamithromycin is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Gamithromycin is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Gamithromycin is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Gamithromycin is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Gamithromycin is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Gamithromycin is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Gamithromycin is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Gamithromycin is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Gamithromycin is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Gamithromycin is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Gamithromycin is combined with (S)-Warfarin.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Gamithromycin.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Gamithromycin.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Gamithromycin.
Lidocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Quinisocaine.
Cisatracurium Gamithromycin may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Gamithromycin is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Gamithromycin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 21949059
    Sargison ND, Scott PR: Metaphylactic gamithromycin treatment for the management of lameness in ewes putatively caused by Bacteroides melaninogenicus. Vet Rec. 2011 Nov 19;169(21):556. doi: 10.1136/vr.d4927. Epub 2011 Sep 22.
  • PMID: 21355734
    Giguere S, Huang R, Malinski TJ, Dorr PM, Tessman RK, Somerville BA: Disposition of gamithromycin in plasma, pulmonary epithelial lining fluid, bronchoalveolar cells, and lung tissue in cattle. Am J Vet Res. 2011 Mar;72(3):326-30. doi: 10.2460/ajvr.72.3.326.
  • PMID: 21443748
    Berghaus LJ, Giguere S, Sturgill TL, Bade D, Malinski TJ, Huang R: Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foals. J Vet Pharmacol Ther. 2012 Feb;35(1):59-66. doi: 10.1111/j.1365-2885.2011.01292.x. Epub 2011 Mar 28.
  • PMID: 23687147
    Watteyn A, Plessers E, Wyns H, De Baere S, De Backer P, Croubels S: Pharmacokinetics of gamithromycin after intravenous and subcutaneous administration in broiler chickens. Poult Sci. 2013 Jun;92(6):1516-22. doi: 10.3382/ps.2012-02932.
  • PMID: 23810743
    Mitchell JD, Goh S, McKellar QA, McKeever DJ: In vitro pharmacodynamics of gamithromycin against Mycoplasma mycoides subspecies mycoides Small Colony. Vet J. 2013 Sep;197(3):806-11. doi: 10.1016/j.tvjl.2013.05.025. Epub 2013 Jun 28.
  • PMID: 20557439
    Huang RA, Letendre LT, Banav N, Fischer J, Somerville B: Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity. J Vet Pharmacol Ther. 2010 Jun 1;33(3):227-37. doi: 10.1111/j.1365-2885.2009.01125.x.
  • PMID: 21493573
    Baggott D, Casartelli A, Fraisse F, Manavella C, Marteau R, Rehbein S, Wiedemann M, Yoon S: Demonstration of the metaphylactic use of gamithromycin against bacterial pathogens associated with bovine respiratory disease in a multicentre farm trial. Vet Rec. 2011 Mar 5;168(9):241. doi: 10.1136/vr.c6776. Epub 2011 Feb 28.
  • PMID: 21078926
    Forbes AB, Ramage C, Sales J, Baggott D, Donachie W: Determination of the duration of antibacterial efficacy following administration of gamithromycin using a bovine Mannheimia haemolytica challenge model. Antimicrob Agents Chemother. 2011 Feb;55(2):831-5. doi: 10.1128/AAC.00552-10. Epub 2010 Nov 15.
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