Florfenicol

DB11413

small molecule experimental vet_approved

Deskripsi

Florfenicol is a fluorinated synthetic analog of thiamphenicol.

Struktur Molekul 2D

Berat 358.21
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

55 Data
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Florfenicol.
BCG vaccine The therapeutic efficacy of BCG vaccine can be decreased when used in combination with Florfenicol.
Typhoid vaccine The therapeutic efficacy of Typhoid vaccine can be decreased when used in combination with Florfenicol.
Dicoumarol The risk or severity of bleeding can be increased when Florfenicol is combined with Dicoumarol.
Phenindione The risk or severity of bleeding can be increased when Florfenicol is combined with Phenindione.
Warfarin The risk or severity of bleeding can be increased when Florfenicol is combined with Warfarin.
Phenprocoumon The risk or severity of bleeding can be increased when Florfenicol is combined with Phenprocoumon.
Acenocoumarol The risk or severity of bleeding can be increased when Florfenicol is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding can be increased when Florfenicol is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding can be increased when Florfenicol is combined with Coumarin.
(R)-warfarin The risk or severity of bleeding can be increased when Florfenicol is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding can be increased when Florfenicol is combined with Ethyl biscoumacetate.
Fluindione The risk or severity of bleeding can be increased when Florfenicol is combined with Fluindione.
Clorindione The risk or severity of bleeding can be increased when Florfenicol is combined with Clorindione.
Diphenadione The risk or severity of bleeding can be increased when Florfenicol is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding can be increased when Florfenicol is combined with Tioclomarol.
(S)-Warfarin The risk or severity of bleeding can be increased when Florfenicol is combined with (S)-Warfarin.
Lactulose The therapeutic efficacy of Lactulose can be decreased when used in combination with Florfenicol.
Vibrio cholerae CVD 103-HgR strain live antigen The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Florfenicol.
Estetrol The therapeutic efficacy of Estetrol can be decreased when used in combination with Florfenicol.
Lidocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Lidocaine.
Ropivacaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Ropivacaine.
Bupivacaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Bupivacaine.
Cinchocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Cinchocaine.
Dyclonine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Dyclonine.
Procaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Procaine.
Prilocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Prilocaine.
Proparacaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Proparacaine.
Meloxicam The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Meloxicam.
Oxybuprocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Oxybuprocaine.
Cocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Cocaine.
Mepivacaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Mepivacaine.
Levobupivacaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Levobupivacaine.
Diphenhydramine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Diphenhydramine.
Benzocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Benzocaine.
Chloroprocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Chloroprocaine.
Phenol The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Phenol.
Tetrodotoxin The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Tetrodotoxin.
Benzyl alcohol The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Benzyl alcohol.
Capsaicin The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Capsaicin.
Etidocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Etidocaine.
Articaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Articaine.
Tetracaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Tetracaine.
Propoxycaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Propoxycaine.
Pramocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Pramocaine.
Butamben The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Butamben.
Butacaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Butacaine.
Oxetacaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Oxetacaine.
Ethyl chloride The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Ethyl chloride.
Butanilicaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Butanilicaine.
Metabutethamine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Metabutethamine.
Quinisocaine The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Quinisocaine.
Cisatracurium Florfenicol may increase the neuromuscular blocking activities of Cisatracurium.
Ambroxol The risk or severity of methemoglobinemia can be increased when Florfenicol is combined with Ambroxol.
Fecal microbiota The therapeutic efficacy of Fecal microbiota can be decreased when used in combination with Florfenicol.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 11475424
    Picco EJ, Diaz DC, Valtorta SE, Boggi JC: Chronotoxicology of florfenicol. Chronobiol Int. 2001 May;18(3):567-72.
  • PMID: 17570454
    Park BK, Lim JH, Kim MS, Hwang YH, Yun HI: Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in dogs. Res Vet Sci. 2008 Feb;84(1):85-9. Epub 2007 Jun 13.
  • PMID: 15175268
    Blickwede M, Valentin-Weigand P, Schwarz S: Subinhibitory concentrations of florfenicol enhance the adherence of florfenicol-susceptible and florfenicol-resistant Staphylococcus aureus. J Antimicrob Chemother. 2004 Jul;54(1):286-8. Epub 2004 Jun 2.
  • PMID: 16670108
    Kehrenberg C, Meunier D, Targant H, Cloeckaert A, Schwarz S, Madec JY: Plasmid-mediated florfenicol resistance in Pasteurella trehalosi. J Antimicrob Chemother. 2006 Jul;58(1):13-7. Epub 2006 May 2.
  • PMID: 12607736
    Hayes JM, Eichman J, Katz T, Gilewicz R: Stability of florfenicol in drinking water. J AOAC Int. 2003 Jan-Feb;86(1):22-9.
  • PMID: 18307512
    Lane VM, Villarroel A, Wetzlich SE, Clifford A, Taylor I, Craigmill AL: Tissue residues of florfenicol in sheep. J Vet Pharmacol Ther. 2008 Apr;31(2):178-80. doi: 10.1111/j.1365-2885.2007.00918.x.
  • PMID: 15102069
    Cook AL, St Claire M, Sams R: Use of florfenicol in non-human primates. J Med Primatol. 2004 Jun;33(3):127-33.
  • PMID: 3806782
    Varma KJ, Adams PE, Powers TE, Powers JD, Lamendola JF: Pharmacokinetics of florfenicol in veal calves. J Vet Pharmacol Ther. 1986 Dec;9(4):412-25.
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