Doramectin

DB11400

small molecule vet_approved

Deskripsi

Doramectin is a veterinary drug approved by the Food and Drug Administration for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites in cattle.

Struktur Molekul 2D

Berat 899.128
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

1003 Data
Buprenorphine Doramectin may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Dronabinol The serum concentration of Dronabinol can be increased when it is combined with Doramectin.
Droperidol Droperidol may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Hydrocodone Doramectin may increase the central nervous system depressant (CNS depressant) activities of Hydrocodone.
Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Magnesium sulfate The therapeutic efficacy of Doramectin can be increased when used in combination with Magnesium sulfate.
Methotrimeprazine Doramectin may increase the central nervous system depressant (CNS depressant) activities of Methotrimeprazine.
Metyrosine Doramectin may increase the sedative activities of Metyrosine.
Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Mirtazapine Doramectin may increase the central nervous system depressant (CNS depressant) activities of Mirtazapine.
Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Orphenadrine Doramectin may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Paraldehyde Doramectin may increase the central nervous system depressant (CNS depressant) activities of Paraldehyde.
Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Pramipexole Doramectin may increase the sedative activities of Pramipexole.
Ropinirole Doramectin may increase the sedative activities of Ropinirole.
Rotigotine Doramectin may increase the sedative activities of Rotigotine.
Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Doramectin.
Sodium oxybate Doramectin may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Suvorexant Doramectin may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Thalidomide Doramectin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Zolpidem Doramectin may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Yohimbine The therapeutic efficacy of Doramectin can be increased when used in combination with Yohimbine.
Eliglustat The metabolism of Eliglustat can be decreased when combined with Doramectin.
Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Doramectin.
Alfentanil The serum concentration of Alfentanil can be increased when it is combined with Doramectin.
Buspirone The metabolism of Buspirone can be decreased when combined with Doramectin.
Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Doramectin.
Cisapride The serum concentration of Cisapride can be increased when it is combined with Doramectin.
Disopyramide Doramectin may increase the QTc-prolonging activities of Disopyramide.
Estazolam The serum concentration of Estazolam can be increased when it is combined with Doramectin.
Quinine The serum concentration of Quinine can be increased when it is combined with Doramectin.
Quinidine The serum concentration of Quinidine can be increased when it is combined with Doramectin.
Repaglinide The serum concentration of Repaglinide can be increased when it is combined with Doramectin.
Sirolimus The metabolism of Sirolimus can be decreased when combined with Doramectin.
Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Doramectin.
Terfenadine The serum concentration of Terfenadine can be increased when it is combined with Doramectin.
Triazolam The serum concentration of Triazolam can be increased when it is combined with Doramectin.
Cilostazol The metabolism of Cilostazol can be decreased when combined with Doramectin.
Colchicine The metabolism of Colchicine can be decreased when combined with Doramectin.
Fentanyl The risk or severity of CNS depression can be increased when Fentanyl is combined with Doramectin.
Iloperidone The metabolism of Iloperidone can be decreased when combined with Doramectin.
Retapamulin The metabolism of Retapamulin can be decreased when combined with Doramectin.
Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Doramectin.
Vardenafil The metabolism of Vardenafil can be decreased when combined with Doramectin.
Zopiclone The metabolism of Zopiclone can be decreased when combined with Doramectin.
Lovastatin The metabolism of Lovastatin can be decreased when combined with Doramectin.
Mefloquine The therapeutic efficacy of Doramectin can be decreased when used in combination with Mefloquine.
Mianserin The therapeutic efficacy of Doramectin can be decreased when used in combination with Mianserin.
Orlistat Orlistat can cause a decrease in the absorption of Doramectin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Topotecan Doramectin may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Doramectin.
Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Doramectin.
Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Doramectin.
Warfarin The serum concentration of Warfarin can be increased when it is combined with Doramectin.
Acenocoumarol The serum concentration of Acenocoumarol can be increased when it is combined with Doramectin.
(R)-warfarin The serum concentration of (R)-warfarin can be increased when it is combined with Doramectin.
R,S-Warfarin alcohol The serum concentration of R,S-Warfarin alcohol can be increased when it is combined with Doramectin.
S,R-Warfarin alcohol The serum concentration of S,R-Warfarin alcohol can be increased when it is combined with Doramectin.
(S)-Warfarin The serum concentration of (S)-Warfarin can be increased when it is combined with Doramectin.
Midazolam The serum concentration of Midazolam can be increased when it is combined with Doramectin.
Tetracosactide The risk or severity of liver damage can be increased when Tetracosactide is combined with Doramectin.
Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Doramectin.
Telaprevir The serum concentration of Telaprevir can be increased when it is combined with Doramectin.
Picosulfuric acid The therapeutic efficacy of Picosulfuric acid can be decreased when used in combination with Doramectin.
Ethanol Doramectin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Azelastine Doramectin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brimonidine Brimonidine may increase the central nervous system depressant (CNS depressant) activities of Doramectin.
Fluvoxamine The risk or severity of adverse effects can be increased when Doramectin is combined with Fluvoxamine.
Citalopram The risk or severity of adverse effects can be increased when Doramectin is combined with Citalopram.
Duloxetine The risk or severity of adverse effects can be increased when Doramectin is combined with Duloxetine.
Trazodone The risk or severity of adverse effects can be increased when Doramectin is combined with Trazodone.
Paroxetine The risk or severity of adverse effects can be increased when Doramectin is combined with Paroxetine.
Sertraline The risk or severity of adverse effects can be increased when Doramectin is combined with Sertraline.
Sibutramine The risk or severity of adverse effects can be increased when Doramectin is combined with Sibutramine.
Nefazodone The risk or severity of adverse effects can be increased when Doramectin is combined with Nefazodone.
Escitalopram The risk or severity of adverse effects can be increased when Doramectin is combined with Escitalopram.
Zimelidine The risk or severity of adverse effects can be increased when Doramectin is combined with Zimelidine.
Dapoxetine The risk or severity of adverse effects can be increased when Doramectin is combined with Dapoxetine.
Milnacipran The risk or severity of adverse effects can be increased when Doramectin is combined with Milnacipran.
Desvenlafaxine The risk or severity of adverse effects can be increased when Doramectin is combined with Desvenlafaxine.
Seproxetine The risk or severity of adverse effects can be increased when Doramectin is combined with Seproxetine.
Indalpine The risk or severity of adverse effects can be increased when Doramectin is combined with Indalpine.
Ritanserin The risk or severity of adverse effects can be increased when Doramectin is combined with Ritanserin.
Alaproclate The risk or severity of adverse effects can be increased when Doramectin is combined with Alaproclate.
Vintafolide The serum concentration of Vintafolide can be increased when it is combined with Doramectin.
Vincamine The serum concentration of Vincamine can be increased when it is combined with Doramectin.
Acetyldigitoxin The serum concentration of Acetyldigitoxin can be increased when it is combined with Doramectin.
Deslanoside The serum concentration of Deslanoside can be increased when it is combined with Doramectin.
Ouabain The serum concentration of Ouabain can be increased when it is combined with Doramectin.
Oleandrin The serum concentration of Oleandrin can be increased when it is combined with Doramectin.
Cymarin The serum concentration of Cymarin can be increased when it is combined with Doramectin.
Proscillaridin The serum concentration of Proscillaridin can be increased when it is combined with Doramectin.
Metildigoxin The serum concentration of Metildigoxin can be increased when it is combined with Doramectin.
Lanatoside C The serum concentration of Lanatoside C can be increased when it is combined with Doramectin.
Gitoformate The serum concentration of Gitoformate can be increased when it is combined with Doramectin.
Acetyldigoxin The serum concentration of Acetyldigoxin can be increased when it is combined with Doramectin.
Peruvoside The serum concentration of Peruvoside can be increased when it is combined with Doramectin.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 8236732
    Authors unspecified: Doramectin--a novel avermectin. Vet Parasitol. 1993 Jul;49(1):1-119.
  • PMID: 8236738
    Goudie AC, Evans NA, Gration KA, Bishop BF, Gibson SP, Holdom KS, Kaye B, Wicks SR, Lewis D, Weatherley AJ, et al.: Doramectin--a potent novel endectocide. Vet Parasitol. 1993 Jul;49(1):5-15.
  • PMID: 14690080
    Yas-Natan E, Shamir M, Kleinbart S, Aroch I: Doramectin toxicity in a collie. Vet Rec. 2003 Dec 6;153(23):718-20.
  • PMID: 8988561
    Stewart TB, Fox MC, Wiles SE: Doramectin efficacy against gastrointestinal nematodes in pigs. Vet Parasitol. 1996 Nov 1;66(1-2):101-8.
  • PMID: 10502489
    Escudero E, Carceles CM, Diaz MS, Sutra JF, Galtier P, Alvinerie M: Pharmacokinetics of moxidectin and doramectin in goats. Res Vet Sci. 1999 Oct;67(2):177-81.
  • PMID: 19614846
    Li N, Jiang H, Li J, Wang Z, Li C, Li X, Ding S: Pharmacokinetics of doramectin in rabbits after subcutaneous administration. J Vet Pharmacol Ther. 2009 Aug;32(4):397-9. doi: 10.1111/j.1365-2885.2008.01044.x.
  • PMID: 10747243
    Atta AH, Abo-Shihada MN: Comparative pharmacokinetics of doramectin and ivermectin in sheep. J Vet Pharmacol Ther. 2000 Feb;23(1):49-52.
  • PMID: 9195716
    Yazwinski TA, Tucker C, Featherston H, Johnson Z, Wood-Huels N: Endectocidal efficacies of doramectin in naturally parasitized pigs. Vet Parasitol. 1997 Jun;70(1-3):123-8.
Menampilkan 8 dari 10 artikel.

Contoh Produk & Brand

Produk: 0 • International brands: 0
Belum ada data produk/brand untuk obat ini pada database. Jalankan import DrugBank untuk mengisi field produk/brand.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
© 2025 Digital Pharmacy Research - Universitas Esa Unggul