Peringatan Keamanan

As cod liver oil consists of the component compounds of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin A, and vitamin D A33159, L2872, L2871 further information about the toxicities of these cod liver oil components can be found by searching for fish oil, vitamin A, and vitamin D on DrugBank.

Cod liver oil

DB11321

small molecule nutraceutical vet_approved

Deskripsi

Cod liver oil is extracted from the liver of cod fish and mainly consists of omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Also being a rich source of vitamin A and D, cod liver oil can be taken orally as daily supplements. It is used as an adjunct treatment and preventative therapy of rickets, osteomalacia and osteoporosis while meeting the consumption criteria.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) As cod liver oil consists of the component compounds of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin A, and vitamin D [A33159, L2872, L2871] further information about the half-lives of these cod liver oil components can be found by searching for fish oil, vitamin A, and vitamin D on DrugBank.

Volume Distribusi As cod liver oil consists of the component compounds of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin A, and vitamin D [A33159, L2872, L2871] further information about the volumes of distribution of these cod liver oil components can be found by searching for fish oil, vitamin A, and vitamin D on DrugBank.

Klirens (Clearance) As cod liver oil consists of the component compounds of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin A, and vitamin D [A33159, L2872, L2871] further information about the clearance of these cod liver oil components can be found by searching for fish oil, vitamin A, and vitamin D on DrugBank.

Absorpsi

As cod liver oil consists of the component compounds of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin A, and vitamin D A33159, L2872, L2871 further information about the absorptions of these cod liver oil components can be found by searching for fish oil, vitamin A, and vitamin D on DrugBank.

Metabolisme

As cod liver oil consists of the component compounds of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin A, and vitamin D A33159, L2872, L2871 further information about the metabolism of these cod liver oil components can be found by searching for fish oil, vitamin A, and vitamin D on DrugBank.

Rute Eliminasi

As cod liver oil consists of the component compounds of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), vitamin A, and vitamin D A33159, L2872, L2871 further information about the routes of elimination of these cod liver oil components can be found by searching for fish oil, vitamin A, and vitamin D on DrugBank.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 25325252
Lentjes MA, Welch AA, Mulligan AA, Luben RN, Wareham NJ, Khaw KT: Cod liver oil supplement consumption and health: cross-sectional results from the EPIC-Norfolk cohort study. Nutrients. 2014 Oct 16;6(10):4320-37. doi: 10.3390/nu6104320.
PMID: 12897318
Rajakumar K: Vitamin D, cod-liver oil, sunlight, and rickets: a historical perspective. Pediatrics. 2003 Aug;112(2):e132-5.
PMID: 12540650
Lips P: Hypervitaminosis A and fractures. N Engl J Med. 2003 Jan 23;348(4):347-9. doi: 10.1056/NEJMe020167.
PMID: 1557095
Haddad JG: Vitamin D--solar rays, the Milky Way, or both? N Engl J Med. 1992 Apr 30;326(18):1213-5. doi: 10.1056/NEJM199204303261808.
PMID: 10617975
von Schacky C: n-3 fatty acids and the prevention of coronary atherosclerosis. Am J Clin Nutr. 2000 Jan;71(1 Suppl):224S-7S. doi: 10.1093/ajcn/71.1.224s.

Link

Contoh Produk & Brand

Produk: 11 • International brands: 0

Produk

Caldesene Medicated Ointment

Ointment • - • Topical • Canada • OTC • Approved
Cod Liver Oil Liq 100%

Liquid • 100 % • Oral • Canada • OTC • Approved
CURACID Dermal for cuts and burns

Ointment • - • Topical • US • OTC
Curefini

Ointment • - • Topical • US • OTC
Curefini

Ointment • - • Topical • US • OTC
Curefini

Ointment • - • Topical • US • OTC
CUREFINI Dermal

Cream • - • Topical • US • OTC
Curefini Dermal

Ointment • - • Topical • US • OTC

Menampilkan 8 dari 11 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.