Peringatan Keamanan

From what studies are available, the overall belief at the moment is that polysilicone-15 largely remains on the surface of the skin when applied and that skin penetration tests demonstrated maximum retention on the skin L2796, F88. The systemic presence of the compound is consequently expected to be minimal.

Polysilicone-15

DB11271

small molecule approved

Deskripsi

Polysilicone-15 is a silicone based UVB absorber L2796, L2797, L2799, F87, F88, F89. The compound is a colorless to pale yellow viscous liquid which is soluble in organic solvents of medium polarity and insoluble in water L2796, L2797, L2799, F87, F88, F89. It is the first polymeric UVB filer consisting of chromophores attached to a silicone backbone L2796, L2797, L2799, F87, F88, F89. When included in various other cosmetic shampoos, conditioners, or hairsprays the compound also functions as an effective photostabilizer of the product L2796, L2797, L2799, F87, F88, F89.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Polysilicone-15 is reported as having little to no absorption through the skin [L2796, F88]. The systemic presence of the compound is consequently expected to be minimal.

Volume Distribusi Polysilicone-15 is reported as having little to no absorption through the skin [L2796, F88]. The systemic presence of the compound is consequently expected to be minimal.

Klirens (Clearance) Polysilicone-15 is reported as having little to no absorption through the skin [L2796, F88]. The systemic presence of the compound is consequently expected to be minimal.

Absorpsi

Polysilicone-15 is reported as having little to no absorption through the skin L2796, F88. At this time, however, studies demonstrate that the components of most commonly used sunscreens are likely absorbed into the skin at least to some extent - although penetration to deeper tissues and the cutaneous circulation remains limited ^A33070. Despite the extensive use of sunscreen products around the world, there have been few reports of adverse effects related to their use ^A33070.

Metabolisme

Polysilicone-15 is reported as having little to no absorption through the skin L2796, F88. The systemic presence of the compound is consequently expected to be minimal.

Rute Eliminasi

Polysilicone-15 is reported as having little to no absorption through the skin L2796, F88. The systemic presence of the compound is consequently expected to be minimal.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 11702366
Benson HA: Assessment and clinical implications of absorption of sunscreens across skin. Am J Clin Dermatol. 2000 Jul-Aug;1(4):217-24.

Link

Attachment

Contoh Produk & Brand

Produk: 6 • International brands: 1

Produk

BRING GREEN Tea Tree CICA Cooling Sun

Stick • - • Topical • US • OTC
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OHUI SUN SCIENCE Perfect Sunblock Blue EX plus

Cream • - • Topical • US • OTC
P.CALM Water Barrier Suncream

Cream • - • Topical • US • OTC
SUN PROJECT SILKY CALMING SUN stick

Stick • - • Topical • US • OTC
The History Of Whoo Gongjinhyang Seol Whitening Sun

Cream • - • Topical • US • OTC

International Brands

Parsol SLX

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.