Peringatan Keamanan

In a rat acute oral toxicity study, median LD50 value was reported to be >2000 mg/kg.^L50226 No case of overdose has been reported. Diethylamino hydroxybenzoyl hexyl benzoate was not shown to be mutagenic, clastogenic, or phototoxic in vitro ^F107. The no observed adverse effect level (NOAEL) 200 mg/kg bw/day for maternal toxicity, and 1000 mg/kg bw/day (highest applied dose) for prenatal developmental toxicity ^F107.

Diethylamino hydroxybenzoyl hexyl benzoate

DB11269

small molecule approved

Deskripsi

Diethylamino hydroxybenzoyl hexyl benzoate is a UV filter with high absorption in the UV-A range. Minimizing the overexposure of human skin to ultraviolet radiation that may lead to acute and chronic photodamage, diethylamino hydroxybenzoyl hexyl benzoate is an oil-soluble UV filter that may be incorporated in the oil phase of emulsions ^F107. Diethylamino hydroxybenzoyl hexyl benzoate was approved in Europe in 2005, and is also marketed in the U.S., South America, Mexico, Japan and Taiwan. It has a chemical structure similar to the classical benxophoenone drug class, and displays good photostability ^A33171. It is used in concentrations up to 10% in sunscreen products, either alone or in combination with other UV absorbers ^F107.

Struktur Molekul 2D

Berat 397.515

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data.

Volume Distribusi No pharmacokinetic data.

Klirens (Clearance) No pharmacokinetic data.

Absorpsi

Based on the findings of a rat study assessing dermal or percutaneous absorption, only a minor amount of diethylamino hydroxybenzoyl hexyl benzoate will undergo percutaneous absorption and most of the compounds will remain in the upper layers of the stratum corneum ^F107. In rat and porcine skin, the percutaneous absorption was 0.10 ± 0.12 ?g/cm^2 or 0.04 ± 0.05% ^F107.

Metabolisme

In steady-state and transient photolysis experiments in vitro, diethylamino hydroxybenzoyl hexyl benzoate may be oxidized by H2O2/UV to form degradation products ^A33172. Like other UV filters, diethylamino hydroxybenzoyl hexyl benzoate may be subject to photodegradation upon absorption of UV radiation, which results in the compound passing from a ground state to either a singlet or triplet excited state ^A33171.

Rute Eliminasi

No pharmacokinetic data.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 28042100
Kawakami CM, Maximo LN, Fontanezi BB, da Silva RS, Gaspar LR: Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) as additive to the UV filter avobenzone in cosmetic sunscreen formulations - Evaluation of the photochemical behavior and photostabilizing effect. Eur J Pharm Sci. 2017 Mar 1;99:299-309. doi: 10.1016/j.ejps.2016.12.031. Epub 2016 Dec 30.
PMID: 25693827
Gong P, Yuan H, Zhai P, Dong W, Li H: Degradation of organic ultraviolet filter diethylamino hydroxybenzoyl hexyl benzoate in aqueous solution by UV/H2O2. Environ Sci Pollut Res Int. 2015 Jul;22(13):10189-95. doi: 10.1007/s11356-015-4166-7. Epub 2015 Feb 20.
PMID: 23284607
Couteau C, Chauvet C, Paparis E, Coiffard L: UV filters, ingredients with a recognized anti-inflammatory effect. PLoS One. 2012;7(12):e46187. doi: 10.1371/journal.pone.0046187. Epub 2012 Dec 20.

Link

EMA Scientific Committee on Consumer Products (SCCP): OPINION ON Diethylamino hydroxybenzoyl hexyl benzoate

Attachment

European Commission: OPINION ON Diethylamino hydroxybenzoyl hexyl benzoate

Contoh Produk & Brand

Produk: 31 • International brands: 1

Produk

Age 20s ESSENCE COVER PACT WHITE DARK BE-35

Cream • - • Topical • US • OTC
Age 20s ESSENCE COVER PACT WHITE DEEP BE-25

Cream • - • Topical • US • OTC
BRING GREEN Tea Tree CICA Cooling Sun

Stick • - • Topical • US • OTC
Calming Days Vegan Sunscreen

Gel • - • Topical • US • OTC
CC Cream SPF 50

Cream • - • Cutaneous; Topical • US • OTC
D-one By Tamdoan Bb Light

Cream • - • Topical • US • OTC
D-one By Tamdoan Bb Medium

Cream • - • Topical • US • OTC
D-one By Tamdoan Sunscreen 50

Cream • - • Topical • US • OTC

Menampilkan 8 dari 31 produk.

International Brands

Uvinul A Plus — BASF

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.