Peringatan Keamanan

An aqueous extract of Curcuma xanthorrhiza did not produce any signs of toxicity in mice or rats up to an oral dose of 2 g/kg bw F114. In a single toxicity study, no mortality was observed after a single oral administration of xanthorrhizol to mice at 500 mg/kg F114. The oral median lethal dose (LD50) of curcumin in mice was >2g/kg bw and single oral doses of curcumin at 1-5 g/kg bw induced no toxic effects in rats.L34044 No case of overdose has been reported.

Curcuma xanthorrhiza oil

DB11265

biotech nutraceutical

Deskripsi

Curcuma xanthorrhiza oil is extracted from Curcuma xanthorrhiza Roxb., a member of the ginger family (Zingiberaceae) that is widely distributed in the region of Southeastern Asia A33162. Curcuma xanthorrhiza is also known as Javanese Turmeric or Temoe Lawak F114. For centuries, Curcuma xanthorrhiza oil has been used as a traditional medicine due to its antibacterial, antispasmodic, antioxidative, antitumor, anti-inflammatory and protective effects A33160. It has been used in the treatment of stomach diseases, liver disorders, constipation, bloody diarrhoea, dysentery, children’s fevers, hypotriglyceridaemic, haemorrhoids and skin eruptions A33162. Curcuma xanthorrhiza oil is comprised of 1-2% of curcumin and 3-12% volatile oil, which mainly contains sesquiterpenes, 44.5% of xanthorrhizol, and a small amount of DB01744 F114. However the principal active components of Curcuma xanthorrhiza are DB11672 and xanthorrhizol that display a wide range of pharmacological activities and synergistic effects F114. Curcumin is a mixture of dicinnamoylmethane derivatives and other phenolic and non-phenolic diarylheptanoids F114. Curcuma xanthorrhiza oil is found as an active ingredient in cosmetic and hygienic products, and marketing of products containing Curcuma xanthorrhiza oil is authorized in some European countries including Germany and the Netherlands F114.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) There are no pharmacokinetic data for xanthorrhizol. Refer to [DB11672] for its pharmacokinetic information.
Volume Distribusi There are no pharmacokinetic data for xanthorrhizol. Refer to [DB11672] for its pharmacokinetic information.
Klirens (Clearance) There are no pharmacokinetic data for xanthorrhizol. Refer to [DB11672] for its pharmacokinetic information.

Absorpsi

There are no pharmacokinetic data for xanthorrhizol. Refer to DB11672 for its pharmacokinetic information.

Metabolisme

There are no pharmacokinetic data for xanthorrhizol. Refer to DB11672 for its pharmacokinetic information.

Rute Eliminasi

There are no pharmacokinetic data for xanthorrhizol. Refer to DB11672 for its pharmacokinetic information.

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 25133223
    Devaraj S, Ismail S, Ramanathan S, Yam MF: Investigation of antioxidant and hepatoprotective activity of standardized Curcuma xanthorrhiza rhizome in carbon tetrachloride-induced hepatic damaged rats. ScientificWorldJournal. 2014;2014:353128. doi: 10.1155/2014/353128. Epub 2014 Jul 14.
  • PMID: 26500452
    Oon SF, Nallappan M, Tee TT, Shohaimi S, Kassim NK, Sa'ariwijaya MS, Cheah YH: Xanthorrhizol: a review of its pharmacological activities and anticancer properties. Cancer Cell Int. 2015 Oct 21;15:100. doi: 10.1186/s12935-015-0255-4. eCollection 2015.
  • PMID: 25190883
    Salea R, Widjojokusumo E, Veriansyah B, Tjandrawinata RR: Optimizing oil and xanthorrhizol extraction from Curcuma xanthorrhiza Roxb. rhizome by supercritical carbon dioxide. J Food Sci Technol. 2014 Sep;51(9):2197-203. doi: 10.1007/s13197-014-1272-3. Epub 2014 Feb 9.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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