Peringatan Keamanan

Organism: Mouse
Test type: LD50
Route : Intraperitoneal
Reported Dose: 275gm/kg ( 275000mg/kg)
Toxic Effect: Details of toxic effects not reported other than lethal dose value

Organism: Mouse
Test type: LDLo
Route : Intravenous
Reported Dose: 1gm/kg ( 1000mg/kg)
Toxic Effect: Details of toxic effects not reported other than lethal dose value

Methylcellulose

DB11228

small molecule approved

Deskripsi

Methyl cellulose polymer consisting of numerous linked glucose molecules used as a stabiliser, thickener and emulsifier for foodstuffs and cosmetics. The Degree of Substitution (DS) of a given form of methyl cellulose is defined as the average number of substituted hydroxyl groups per glucose with a theoretical maximum of 3, however more typical values are 1.3 2.6. Methyl cellulose is a hydrophilic white powder in pure form and dissolves in cold (but not in hot) water, forming a clear viscous solution or gel. It is available under a variety of trade names as a treatment for constipation. Like cellulose, it is not digestible, not toxic, and not allergenic

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) 4.2 minutes

Volume Distribusi accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.

Klirens (Clearance) -

Absorpsi

Cellulose derivatives considered in this report are virtually unabsorbed and little or no degradation of absorbed and little or no degradation of absorbable products occurs in the human digestive tract. In humans, virtually 100 percent of orally ingested methyl cellulose can be recovered in the feces withihn four days, indicating that absorption does not occur.

Metabolisme

Reported that when methylcellulose was given iv to dog and rabbit , aside from effect upon circulating blood, inability of body to degrade substance led to its retention & accumulation in liver, spleen, lymph nodes, kidney, and vascular walls.

Rute Eliminasi

When swallowed they are not absorbed to any appreciable degree and appear unchanged in feces.

Interaksi Makanan

1 Data

1. Take with a full glass of water.

Interaksi Obat

400 Data

Tramadol	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Tramadol.
Trospium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Trospium.
Oxyphenonium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Oxyphenonium.
Benzatropine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Benzatropine.
Ziprasidone	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Ziprasidone.
Disopyramide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Disopyramide.
Amitriptyline	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Amitriptyline.
Ipratropium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Ipratropium.
Olanzapine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Olanzapine.
Metixene	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Metixene.
Terfenadine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Terfenadine.
Buclizine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Buclizine.
Clozapine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Clozapine.
Doxylamine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Doxylamine.
Trihexyphenidyl	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Oxyphencyclimine.
Procyclidine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Procyclidine.
Profenamine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Profenamine.
Promazine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Promazine.
Hyoscyamine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Hyoscyamine.
Cyproheptadine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Cyproheptadine.
Imipramine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Imipramine.
Methscopolamine bromide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Methscopolamine bromide.
Chlorpromazine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Chlorpromazine.
Gallamine triethiodide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Gallamine triethiodide.
Darifenacin	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Darifenacin.
Tridihexethyl	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Tridihexethyl.
Triflupromazine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Triflupromazine.
Anisotropine methylbromide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Nortriptyline.
Amoxapine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Amoxapine.
Atropine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Atropine.
Nicardipine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Nicardipine.
Pirenzepine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Pirenzepine.
Paroxetine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Paroxetine.
Homatropine methylbromide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Homatropine methylbromide.
Rocuronium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Rocuronium.
Scopolamine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Scopolamine.
Benzquinamide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Benzquinamide.
Clidinium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Clidinium.
Propiomazine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Propiomazine.
Propantheline	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Propantheline.
Dicyclomine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Dicyclomine.
Biperiden	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Biperiden.
Brompheniramine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Brompheniramine.
Flupentixol	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Flupentixol.
Cocaine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Cocaine.
Quinidine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Quinidine.
Maprotiline	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Maprotiline.
Methantheline	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Methantheline.
Cycrimine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Cycrimine.
Glycopyrronium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Glycopyrronium.
Tolterodine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Tolterodine.
Oxybutynin	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Oxybutynin.
Promethazine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Promethazine.
Diphenhydramine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Diphenhydramine.
Doxacurium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Doxacurium.
Doxepin	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Doxepin.
Flavoxate	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Flavoxate.
Desipramine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Desipramine.
Orphenadrine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Orphenadrine.
Escitalopram	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Escitalopram.
Quetiapine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Quetiapine.
Mivacurium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Mivacurium.
Diphenidol	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Diphenidol.
Aripiprazole	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Aripiprazole.
Chlorprothixene	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Chlorprothixene.
Metocurine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Metocurine.
Pancuronium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Pancuronium.
Pipecuronium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Pipecuronium.
Methotrimeprazine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Methotrimeprazine.
Tiotropium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Tiotropium.
Solifenacin	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Solifenacin.
Isopropamide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Isopropamide.
Rapacuronium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Rapacuronium.
Mepenzolate	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Mepenzolate.
Pizotifen	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Pizotifen.
Fesoterodine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Fesoterodine.
Hexocyclium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Hexocyclium.
Dimetindene	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Dimetindene.
Aclidinium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Aclidinium.
Dexetimide	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Dexetimide.
Benactyzine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Benactyzine.
Umeclidinium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Umeclidinium.
Trimebutine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Trimebutine.
Dosulepin	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Dosulepin.
Imidafenacin	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Imidafenacin.
Butylscopolamine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Butylscopolamine.
Thonzylamine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Thonzylamine.
Methscopolamine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Methscopolamine.
Revefenacin	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Revefenacin.
Oxitropium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Oxitropium.
Propiverine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Propiverine.
Batefenterol	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Batefenterol.
Mebeverine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Mebeverine.
Tropatepine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Tropatepine.
Prifinium	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Prifinium.
Piperidolate	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Piperidolate.
Benzilone	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Benzilone.
Difemerine	The therapeutic efficacy of Methylcellulose can be decreased when used in combination with Difemerine.

Referensi & Sumber

Link

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.