Peringatan Keamanan

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin ^F101. The systemic presence of the compound is consequently expected to be minimal. Additionally, no ocular irritation, phototoxicity, dermal irritation, or allergic contact sensitization has been reported to any significant degree ^L2847.

Ethylhexyl methoxycrylene

DB11226

small molecule approved experimental

Deskripsi

Ethylhexyl methoxycrylene is a photostabilizer that preserves the effectiveness of UV filters by interacting with both the singlet and triplet states ^F104. It returns UV filters to their ground states without absorbing sunlight ^F104. It is used as a solvent for crystalline UV filters and is easily emulsified and suitable for use in various lotions, creams, sprays, sticks, and gel formulations ^F104. It currently enjoys regional approvals in Canada, the EU, and the US ^L2847.

Struktur Molekul 2D

Berat 391.511

Wujud -

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin [F101]. The systemic presence of the compound is consequently expected to be minimal.

Volume Distribusi Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin [F101]. The systemic presence of the compound is consequently expected to be minimal.

Klirens (Clearance) Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin [F101]. The systemic presence of the compound is consequently expected to be minimal.

Absorpsi

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin ^F101. At this time, however, studies demonstrate that the components of most commonly used sunscreens are likely absorbed into the skin at least to some extent - although penetration to deeper tissues and the cutaneous circulation remains limited ^A33070. Despite the extensive use of sunscreen products around the world, there have been few reports of adverse effects related to their use ^A33070.

Metabolisme

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin ^F101. The systemic presence of the compound is consequently expected to be minimal.

Rute Eliminasi

Ethylhexyl methoxycrylene is reported as having little to no absorption through the skin ^F101. The systemic presence of the compound is consequently expected to be minimal.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 23136952
Kikuchi A, Hata Y, Kumasaka R, Nanbu Y, Yagi M: Photoexcited singlet and triplet states of a UV absorber ethylhexyl methoxycrylene. Photochem Photobiol. 2013 May-Jun;89(3):523-8. doi: 10.1111/php.12017. Epub 2012 Dec 17.
PMID: 11702366
Benson HA: Assessment and clinical implications of absorption of sunscreens across skin. Am J Clin Dermatol. 2000 Jul-Aug;1(4):217-24.

Link

Hallstar: SolaStay S1 Product Profile

Attachment

Contoh Produk & Brand

Produk: 3 • International brands: 1

Produk

Almost Makeup SPF 15

Powder • - • Topical • US • OTC
Almost Makeup SPF 18

Powder • - • Topical • US • OTC
Sunscreen SPF30

Liquid • - • Topical • US • OTC

International Brands

Solastay S1

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.