Peringatan Keamanan

No toxicokinetic data available.

Dioxybenzone

DB11221

small molecule approved

Deskripsi

Dioxybenzone, or benzophenone-8, is an organic compound derived from DB01878 that is used as a sunscreen agent. It absorbed UV-B and UV-AII rays. Dioxybenzone is an approved sunscreen ingredient in concentrations up to 3% ^L2525.

Struktur Molekul 2D

Berat 244.246

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data available.

Volume Distribusi No pharmacokinetic data available.

Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

Dioxybenzone is a derivative of benzophenone. In monkeys, percutaneous absorption of benzophenone was observed ^L2525. Other derivatives of benzophenone are capable of crossing the skin via direct penetration through the intercellular laminae of the stratum corneum (SC) or by passive diffusion by high-concentration gradient into the systemic circulation, where they are transported to different tissues including liver and brain ^A32726.

Metabolisme

No pharmacokinetic data available.

Rute Eliminasi

No pharmacokinetic data available.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Sex hormone-binding globulin SHBG

Referensi & Sumber

Artikel (PubMed)

PMID: 28959646
Ruszkiewicz JA, Pinkas A, Ferrer B, Peres TV, Tsatsakis A, Aschner M: Neurotoxic effect of active ingredients in sunscreen products, a contemporary review. Toxicol Rep. 2017 May 27;4:245-259. doi: 10.1016/j.toxrep.2017.05.006. eCollection 2017.
PMID: 23749905
Rao GS, Tokuda H, Ichiishi E, Takasaki M, Iida A, Suzuki N, Konoshima T, Kapadia GJ: Oral chemoprevention of skin cancer in mice by benzophenone sunscreens dioxybenzone and octabenzone in drinking water. Anticancer Res. 2013 Jun;33(6):2535-40.
PMID: 27690075
Hong H, Rua D, Sakkiah S, Selvaraj C, Ge W, Tong W: Consensus Modeling for Prediction of Estrogenic Activity of Ingredients Commonly Used in Sunscreen Products. Int J Environ Res Public Health. 2016 Sep 29;13(10). pii: ijerph13100958. doi: 10.3390/ijerph13100958.

Link

Contoh Produk & Brand

Produk: 6 • International brands: 0

Produk

Hydroquinone with sunscreens

Cream • - • Topical • US
Nuquin Hp

Cream • - • Topical • US
Nuquin Hp

Gel • - • Topical • US
Perrigo Hydroquinone with sunscreens

Gel • - • Topical • US
Perrigo Hydroquinone with sunscreens

Cream • - • Topical • US
Viquin Forte With Moisturizing Aha - Crm

Cream • - • Topical • Canada • Approved

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.