Peringatan Keamanan

Salicylate intoxication may occur after ingestion or topical application of menthyl salicylate.
Mild chronic salicylate intoxication, also known as salicylism, normally occurs only after repeated use of large doses.

Salicylism can also occur following the excessive topical application of salicylates. Symptoms of toxicity include dizziness, tinnitus, deafness, sweating, nausea and vomiting, headache, and confusion, and may be controlled by reducing the dosage F91.

Symptoms of more severe intoxication or of acute poisoning following overdose include hyperventilation, fever, restlessness, ketosis, and respiratory alkalosis and metabolic acidosis. Depression of the CNS may lead to coma, cardiovascular collapse and respiratory failure may also result F91.

Menthyl salicylate

DB11201

small molecule approved

Deskripsi

Menthyl salicylate is an ester of menthol and salicylic acid L2808.

This product is used to treat minor aches and pains of the muscles/joints (e.g., arthritis, backache, sprains) L2810.

Struktur Molekul 2D

Berat 276.376
Wujud liquid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

May be absorbed through intact skin. The absorption of topical salicylates is proportional to the surface area exposed, the duration of exposure, concentration and skin integrity. Absorption characteristics of salicylates vary with the dose, formulation, and route of administration. Percutaneous absorption is enhanced by exercise, heat, occlusion, or disruption of the integrity of the skin or application to large areas of skin. Both the rate and extent of absorption increases after continuous application, increasing its bioavailability F91.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

652 Data
Aliskiren The risk or severity of renal failure and hypertension can be increased when Menthyl salicylate is combined with Aliskiren.
Deferasirox The risk or severity of gastrointestinal bleeding and peptic ulcer can be increased when Menthyl salicylate is combined with Deferasirox.
Desmopressin The risk or severity of hypertension, hyponatremia, and water intoxication can be increased when Menthyl salicylate is combined with Desmopressin.
Digoxin Menthyl salicylate may decrease the excretion rate of Digoxin which could result in a higher serum level.
Metildigoxin Menthyl salicylate may decrease the excretion rate of Metildigoxin which could result in a higher serum level.
Acetyldigoxin Menthyl salicylate may decrease the excretion rate of Acetyldigoxin which could result in a higher serum level.
Drospirenone The risk or severity of hyperkalemia can be increased when Menthyl salicylate is combined with Drospirenone.
Haloperidol The therapeutic efficacy of Haloperidol can be increased when used in combination with Menthyl salicylate.
Hydralazine Menthyl salicylate may decrease the antihypertensive activities of Hydralazine.
Lithium hydroxide Menthyl salicylate may decrease the excretion rate of Lithium hydroxide which could result in a higher serum level.
Lithium citrate Menthyl salicylate may decrease the excretion rate of Lithium citrate which could result in a higher serum level.
Lithium carbonate Menthyl salicylate may decrease the excretion rate of Lithium carbonate which could result in a higher serum level.
Methotrexate The serum concentration of Methotrexate can be increased when it is combined with Menthyl salicylate.
Pemetrexed Menthyl salicylate may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Pralatrexate Menthyl salicylate may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Probenecid Probenecid may decrease the excretion rate of Menthyl salicylate which could result in a higher serum level.
Tenofovir disoproxil Menthyl salicylate may decrease the excretion rate of Tenofovir disoproxil which could result in a higher serum level.
Tenofovir alafenamide Menthyl salicylate may decrease the excretion rate of Tenofovir alafenamide which could result in a higher serum level.
Tenofovir Menthyl salicylate may decrease the excretion rate of Tenofovir which could result in a higher serum level.
Treprostinil The risk or severity of bleeding can be increased when Treprostinil is combined with Menthyl salicylate.
Vancomycin Menthyl salicylate may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Alendronic acid The risk or severity of adverse effects can be increased when Menthyl salicylate is combined with Alendronic acid.
Lepirudin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Lepirudin.
Bivalirudin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Bivalirudin.
Alteplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Alteplase.
Urokinase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Urokinase.
Reteplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Reteplase.
Anistreplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Anistreplase.
Tenecteplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Tenecteplase.
Abciximab The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Abciximab.
Drotrecogin alfa The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Drotrecogin alfa.
Streptokinase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Streptokinase.
Dicoumarol The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Dicoumarol.
Argatroban The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Argatroban.
Ardeparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Ardeparin.
Phenindione The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Phenindione.
Fondaparinux The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Fondaparinux.
Warfarin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Warfarin.
Pentosan polysulfate The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Pentosan polysulfate.
Phenprocoumon The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Phenprocoumon.
Edetic acid The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Edetic acid.
Dipyridamole The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Dipyridamole.
Heparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Heparin.
Enoxaparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Enoxaparin.
Epoprostenol The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Epoprostenol.
Acenocoumarol The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Acenocoumarol.
4-hydroxycoumarin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with 4-hydroxycoumarin.
Coumarin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Coumarin.
Ximelagatran The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Ximelagatran.
Desmoteplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Desmoteplase.
Defibrotide The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Defibrotide.
Ancrod The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Ancrod.
Beraprost The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Beraprost.
SR-123781A The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with SR-123781A.
Prasugrel The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Prasugrel.
Rivaroxaban The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Rivaroxaban.
Sulodexide The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Sulodexide.
Semuloparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Semuloparin.
Idraparinux The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Idraparinux.
Cangrelor The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Cangrelor.
Astaxanthin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Astaxanthin.
Apixaban The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Apixaban.
Otamixaban The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Otamixaban.
Amediplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Amediplase.
Dabigatran etexilate The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Dabigatran etexilate.
Danaparoid The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Danaparoid.
Dalteparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Dalteparin.
Tinzaparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Tinzaparin.
(R)-warfarin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with (R)-warfarin.
Ethyl biscoumacetate The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Ethyl biscoumacetate.
Nadroparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Nadroparin.
Triflusal The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Triflusal.
Ticagrelor The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Ticagrelor.
Ditazole The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Ditazole.
Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Vorapaxar.
Edoxaban The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Edoxaban.
Sodium citrate The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Sodium citrate.
Dextran The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Dextran.
Bemiparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Bemiparin.
Reviparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Reviparin.
Parnaparin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Parnaparin.
Desirudin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Desirudin.
Antithrombin Alfa The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Antithrombin Alfa.
Protein C The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Protein C.
Antithrombin III human The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Antithrombin III human.
Letaxaban The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Letaxaban.
Darexaban The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Darexaban.
Betrixaban The risk or severity of bleeding can be increased when Betrixaban is combined with Menthyl salicylate.
Nafamostat The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Nafamostat.
Monteplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Monteplase.
Gabexate The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Gabexate.
Troxerutin The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Troxerutin.
Fluindione The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Fluindione.
Protein S human The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Protein S human.
Brinase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Brinase.
Clorindione The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Clorindione.
Diphenadione The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Diphenadione.
Tioclomarol The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Tioclomarol.
Melagatran The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Melagatran.
Saruplase The risk or severity of bleeding and hemorrhage can be increased when Menthyl salicylate is combined with Saruplase.

Target Protein

Prostaglandin G/H synthase 1 PTGS1
Prostaglandin G/H synthase 2 PTGS2

Contoh Produk & Brand

Produk: 16 • International brands: 0
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Menampilkan 8 dari 16 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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