The EU has published a statement of caution that antiperspirant should not be applied to damaged or irritated skin, yet it is common to shave the underarm area before applying antiperspirant F48.
The possible health risks of aluminum containing antiperspirant use are not well studied. Although it has been suggested that deodorant and/or antiperspirant use is associated with incidence or age of breast cancer diagnosis A32464, a causal relationship between aluminium product use and breast cancer has not been established A32967, A32971.
The oral toxicity of aluminium compounds for which data are available (bromide, nitrate, chloride and sulfate) is moderate to low, with LD50 values in the range of 162 to 750 mg Al/kg in rats, and from 164 to 980 mg Al/kg in mice, depending on the type of aluminium compound studied F48.
Aluminum zirconium octachlorohydrex gly is complex that consists of aluminum zirconium octachlorohydrate and glycine. It is an active antiperspirant agent L2705, L2706. It diffuses into the sweat pores and prevents perspiration (sweat) from leaving the pores. The anhydrous form of the compound also has water-absorbing properties. Currently, the FDA allows the inclusion of this substance in concentrations of up to 20% in antiperspirants L2012.
Interestingly, this chemical has been studied in relation to its possible impact on the microbiome of the human underarms A32967.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.