Peringatan Keamanan

Acute oral LD50 of 200 mcu papain is 4000 mg/kg in rat and 12500 mg/kg in mouse MSDS. It acts as an irritant in case of inhalation or contact with eyes.

Papain

DB11193

biotech approved

Deskripsi

Papain, also known as papaya proteinase I, is a cysteine protease (EC 3.4.22.2) enzyme that is found in species of papaya, Carica papaya and Vasconcellea cundinamarcensis. The enzyme is found to be localized in the skin of papaya, and is collected from slashed unripe papayas as a crude latex. Papain is used in food, pharmaceutical, textile, and cosmetic industries. While it has been used for the treatment of inflammation and pain via topical administration, papain has also shown to have anthelmintic and tooth-whitening properties. Present in over-the-counter mixture products consisting of different digestive enzymes, its active site contains a catalytic diad that plays a role in breaking peptide bonds. Papain is also used as an ingredient in various enzymatic debriding preparations.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data available.
Volume Distribusi No pharmacokinetic data available.
Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

No pharmacokinetic data available.

Metabolisme

No pharmacokinetic data available.

Rute Eliminasi

No pharmacokinetic data available.

Interaksi Obat

0 Data
Tidak ada data.

Target Protein

Toll-like receptor 4 TLR4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 25705851
    Stremnitzer C, Manzano-Szalai K, Willensdorfer A, Starkl P, Pieper M, Konig P, Mildner M, Tschachler E, Reichart U, Jensen-Jarolim E: Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation. J Invest Dermatol. 2015 Jul;135(7):1790-1800. doi: 10.1038/jid.2015.58. Epub 2015 Feb 23.

Contoh Produk & Brand

Produk: 16 • International brands: 0
Produk
  • BEAUTIFUL CONTRACT - Deep V Breast contract -Hui Ju Sheng Enterprise Corporation Ltd.
    Capsule, gelatin coated • 35 mg/500mg • Oral • US • OTC
  • Bromelain and Papain Tab
    Tablet • - • Oral • Canada • OTC • Approved
  • Chewable Enzymes Tablets
    Tablet • - • Oral • Canada • OTC • Approved
  • Dygest
    Tablet • - • Oral • Canada • OTC • Approved
  • Enzyme Tablets
    Tablet • - • Oral • Canada • OTC • Approved
  • Herbalax Forte No 70 Tab
    Tablet • - • Oral • Canada • OTC • Approved
  • Master Key Formula 3 Tab
    Tablet • - • Oral • Canada • OTC • Approved
  • Neo Life Beta Gest Tab
    Tablet • - • Oral • Canada • OTC • Approved
Menampilkan 8 dari 16 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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