Acute oral LD50 is 1200 mg/kg in rat, 1400 mg/kg in mouse, and 1000 mg/kg in guinea pig MSDS. Systemic toxicity may occur following topical overdose of structurally-related ophthalmic atropine, particularly in children. It is characterized by flushing and dryness of the skin, blurred vision, a rapid and irregular pulse, fever, convulsions and hallucinations, and the loss of neuromuscular coordination. Abdominal distension may be observed with infants. Severe intoxication is manifested by central nervous system depression, coma, circulatory and respiratory failure, and death FDA Label. Symptomatic and supportive treatment should be initiated. In case of accidental use or overdose in infants and small children, the body surface should be kept moist FDA Label.
Homatropine is an anticholinergic drug that acts as an antagonist at muscarinic acetylcholine receptors. It is present in antitussives, under the trade name Hycodan, in combination with hydrocodone (dihydrocodeinone) bitartrate indicated for the symptomatic relief of cough as oral tablets or solutions. Homatropine is included in subtherapeutic amounts as homatropine methylbromide to discourage deliberate overdosage. Homatropine hydrobromide has been administered as ophthalmic solutions as a cycloplegic to temporarily paralyze accomodation, and to induce mydriasis (the dilation of the pupil); however such therapeutic use has not been approved by the FDA to be safe and effective.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Tramadol | The risk or severity of adverse effects can be increased when Tramadol is combined with Homatropine. |
| Trospium | The risk or severity of adverse effects can be increased when Trospium is combined with Homatropine. |
| Oxyphenonium | The risk or severity of adverse effects can be increased when Oxyphenonium is combined with Homatropine. |
| Butabarbital | The risk or severity of adverse effects can be increased when Butabarbital is combined with Homatropine. |
| Butalbital | The risk or severity of adverse effects can be increased when Butalbital is combined with Homatropine. |
| Benzatropine | The risk or severity of adverse effects can be increased when Benzatropine is combined with Homatropine. |
| Ziprasidone | The risk or severity of adverse effects can be increased when Ziprasidone is combined with Homatropine. |
| Disopyramide | The risk or severity of adverse effects can be increased when Disopyramide is combined with Homatropine. |
| Talbutal | The risk or severity of adverse effects can be increased when Talbutal is combined with Homatropine. |
| Pentobarbital | The risk or severity of adverse effects can be increased when Pentobarbital is combined with Homatropine. |
| Amitriptyline | The risk or severity of adverse effects can be increased when Amitriptyline is combined with Homatropine. |
| Ipratropium | The risk or severity of adverse effects can be increased when Ipratropium is combined with Homatropine. |
| Methadone | The risk or severity of adverse effects can be increased when Methadone is combined with Homatropine. |
| Olanzapine | The risk or severity of adverse effects can be increased when Olanzapine is combined with Homatropine. |
| Metixene | The risk or severity of adverse effects can be increased when Metixene is combined with Homatropine. |
| Terfenadine | The risk or severity of adverse effects can be increased when Terfenadine is combined with Homatropine. |
| Buclizine | The risk or severity of adverse effects can be increased when Buclizine is combined with Homatropine. |
| Clozapine | The risk or severity of reduced gastrointestinal motility can be increased when Homatropine is combined with Clozapine. |
| Doxylamine | The risk or severity of adverse effects can be increased when Doxylamine is combined with Homatropine. |
| Trihexyphenidyl | The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Homatropine. |
| Oxyphencyclimine | The risk or severity of adverse effects can be increased when Oxyphencyclimine is combined with Homatropine. |
| Procyclidine | The risk or severity of adverse effects can be increased when Procyclidine is combined with Homatropine. |
| Profenamine | The risk or severity of adverse effects can be increased when Profenamine is combined with Homatropine. |
| Metocurine iodide | The risk or severity of adverse effects can be increased when Metocurine iodide is combined with Homatropine. |
| Secobarbital | The risk or severity of adverse effects can be increased when Secobarbital is combined with Homatropine. |
| Promazine | The risk or severity of adverse effects can be increased when Promazine is combined with Homatropine. |
| Hyoscyamine | The risk or severity of adverse effects can be increased when Hyoscyamine is combined with Homatropine. |
| Cyproheptadine | The risk or severity of adverse effects can be increased when Cyproheptadine is combined with Homatropine. |
| Imipramine | The risk or severity of adverse effects can be increased when Imipramine is combined with Homatropine. |
| Methscopolamine bromide | The risk or severity of adverse effects can be increased when Methscopolamine bromide is combined with Homatropine. |
| Metharbital | The risk or severity of adverse effects can be increased when Metharbital is combined with Homatropine. |
| Fluoxetine | The risk or severity of adverse effects can be increased when Fluoxetine is combined with Homatropine. |
| Chlorpromazine | The risk or severity of adverse effects can be increased when Chlorpromazine is combined with Homatropine. |
| Gallamine triethiodide | The risk or severity of adverse effects can be increased when Gallamine triethiodide is combined with Homatropine. |
| Darifenacin | The risk or severity of adverse effects can be increased when Darifenacin is combined with Homatropine. |
| Tridihexethyl | The risk or severity of adverse effects can be increased when Tridihexethyl is combined with Homatropine. |
| Triflupromazine | The risk or severity of adverse effects can be increased when Triflupromazine is combined with Homatropine. |
| Dextromethorphan | The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Homatropine. |
| Anisotropine methylbromide | The risk or severity of adverse effects can be increased when Anisotropine methylbromide is combined with Homatropine. |
| Nortriptyline | The risk or severity of adverse effects can be increased when Nortriptyline is combined with Homatropine. |
| Amoxapine | The risk or severity of adverse effects can be increased when Amoxapine is combined with Homatropine. |
| Cisatracurium | The risk or severity of adverse effects can be increased when Cisatracurium is combined with Homatropine. |
| Atropine | The risk or severity of adverse effects can be increased when Atropine is combined with Homatropine. |
| Thiopental | The risk or severity of adverse effects can be increased when Thiopental is combined with Homatropine. |
| Nicardipine | The risk or severity of adverse effects can be increased when Nicardipine is combined with Homatropine. |
| Mecamylamine | The risk or severity of adverse effects can be increased when Mecamylamine is combined with Homatropine. |
| Pirenzepine | The risk or severity of adverse effects can be increased when Pirenzepine is combined with Homatropine. |
| Paroxetine | The risk or severity of adverse effects can be increased when Paroxetine is combined with Homatropine. |
| Procaine | The risk or severity of adverse effects can be increased when Procaine is combined with Homatropine. |
| Homatropine methylbromide | The risk or severity of adverse effects can be increased when Homatropine methylbromide is combined with Homatropine. |
| Rocuronium | The risk or severity of adverse effects can be increased when Rocuronium is combined with Homatropine. |
| Atracurium besylate | The risk or severity of adverse effects can be increased when Atracurium besylate is combined with Homatropine. |
| Scopolamine | The risk or severity of adverse effects can be increased when Scopolamine is combined with Homatropine. |
| Isoflurane | The risk or severity of adverse effects can be increased when Isoflurane is combined with Homatropine. |
| Benzquinamide | The risk or severity of adverse effects can be increased when Benzquinamide is combined with Homatropine. |
| Clidinium | The risk or severity of adverse effects can be increased when Clidinium is combined with Homatropine. |
| Propiomazine | The risk or severity of adverse effects can be increased when Propiomazine is combined with Homatropine. |
| Propantheline | The risk or severity of adverse effects can be increased when Propantheline is combined with Homatropine. |
| Primidone | The risk or severity of adverse effects can be increased when Primidone is combined with Homatropine. |
| Dicyclomine | The risk or severity of adverse effects can be increased when Dicyclomine is combined with Homatropine. |
| Tropicamide | The risk or severity of adverse effects can be increased when Tropicamide is combined with Homatropine. |
| Biperiden | The risk or severity of adverse effects can be increased when Biperiden is combined with Homatropine. |
| Brompheniramine | The risk or severity of adverse effects can be increased when Brompheniramine is combined with Homatropine. |
| Methylphenobarbital | The risk or severity of adverse effects can be increased when Methylphenobarbital is combined with Homatropine. |
| Cocaine | The risk or severity of adverse effects can be increased when Cocaine is combined with Homatropine. |
| Quinidine | The risk or severity of adverse effects can be increased when Quinidine is combined with Homatropine. |
| Amantadine | The risk or severity of adverse effects can be increased when Amantadine is combined with Homatropine. |
| Maprotiline | The risk or severity of adverse effects can be increased when Maprotiline is combined with Homatropine. |
| Methantheline | The risk or severity of adverse effects can be increased when Methantheline is combined with Homatropine. |
| Hexafluronium | The risk or severity of adverse effects can be increased when Hexafluronium is combined with Homatropine. |
| Cycrimine | The risk or severity of adverse effects can be increased when Cycrimine is combined with Homatropine. |
| Desloratadine | The risk or severity of adverse effects can be increased when Desloratadine is combined with Homatropine. |
| Cyclopentolate | The risk or severity of adverse effects can be increased when Cyclopentolate is combined with Homatropine. |
| Glycopyrronium | The risk or severity of adverse effects can be increased when Glycopyrronium is combined with Homatropine. |
| Tolterodine | The risk or severity of adverse effects can be increased when Tolterodine is combined with Homatropine. |
| Oxybutynin | The risk or severity of adverse effects can be increased when Oxybutynin is combined with Homatropine. |
| Promethazine | The risk or severity of adverse effects can be increased when Promethazine is combined with Homatropine. |
| Diphenhydramine | The risk or severity of adverse effects can be increased when Diphenhydramine is combined with Homatropine. |
| Pentolinium | The risk or severity of adverse effects can be increased when Pentolinium is combined with Homatropine. |
| Trimethaphan | The risk or severity of adverse effects can be increased when Trimethaphan is combined with Homatropine. |
| Doxacurium | The risk or severity of adverse effects can be increased when Doxacurium is combined with Homatropine. |
| Doxepin | The risk or severity of adverse effects can be increased when Doxepin is combined with Homatropine. |
| Flavoxate | The risk or severity of adverse effects can be increased when Flavoxate is combined with Homatropine. |
| Desipramine | The risk or severity of adverse effects can be increased when Desipramine is combined with Homatropine. |
| Orphenadrine | The risk or severity of adverse effects can be increased when Orphenadrine is combined with Homatropine. |
| Phenobarbital | The risk or severity of adverse effects can be increased when Phenobarbital is combined with Homatropine. |
| Escitalopram | The risk or severity of adverse effects can be increased when Escitalopram is combined with Homatropine. |
| Tubocurarine | The risk or severity of adverse effects can be increased when Tubocurarine is combined with Homatropine. |
| Quetiapine | The risk or severity of adverse effects can be increased when Quetiapine is combined with Homatropine. |
| Mivacurium | The risk or severity of adverse effects can be increased when Mivacurium is combined with Homatropine. |
| Levacetylmethadol | The risk or severity of adverse effects can be increased when Levacetylmethadol is combined with Homatropine. |
| Diphenidol | The risk or severity of adverse effects can be increased when Diphenidol is combined with Homatropine. |
| Aripiprazole | The risk or severity of adverse effects can be increased when Aripiprazole is combined with Homatropine. |
| Chlorprothixene | The risk or severity of adverse effects can be increased when Chlorprothixene is combined with Homatropine. |
| Fenoterol | The risk or severity of adverse effects can be increased when Fenoterol is combined with Homatropine. |
| Metocurine | The risk or severity of adverse effects can be increased when Metocurine is combined with Homatropine. |
| Pancuronium | The risk or severity of adverse effects can be increased when Pancuronium is combined with Homatropine. |
| Pipecuronium | The risk or severity of adverse effects can be increased when Pipecuronium is combined with Homatropine. |
| Vecuronium | The risk or severity of adverse effects can be increased when Vecuronium is combined with Homatropine. |
| Amobarbital | The risk or severity of adverse effects can be increased when Amobarbital is combined with Homatropine. |