Highest dose tested was 360mg/kg/day in rats resulted in transient limb swelling.
Antithrombin Alfa is a recombinant antithrombin , an anticoagulant, that is used for the prevention of thromboembolic events in patients that have hereditary deficiency of antithrombin in high risk situations.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.
| Apixaban | Apixaban may increase the anticoagulant activities of Antithrombin Alfa. |
| Dabigatran etexilate | Dabigatran etexilate may increase the anticoagulant activities of Antithrombin Alfa. |
| Dasatinib | The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Antithrombin Alfa. |
| Deferasirox | The risk or severity of gastrointestinal bleeding can be increased when Antithrombin Alfa is combined with Deferasirox. |
| Ursodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Ursodeoxycholic acid. |
| Glycochenodeoxycholic Acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Glycochenodeoxycholic Acid. |
| Cholic Acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Cholic Acid. |
| Glycocholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Glycocholic acid. |
| Deoxycholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Deoxycholic acid. |
| Taurocholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Taurocholic acid. |
| Obeticholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Obeticholic acid. |
| Chenodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Chenodeoxycholic acid. |
| Taurochenodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Taurochenodeoxycholic acid. |
| Tauroursodeoxycholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Tauroursodeoxycholic acid. |
| Bamet-UD2 | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Bamet-UD2. |
| Dehydrocholic acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Dehydrocholic acid. |
| Hyodeoxycholic Acid | The risk or severity of bleeding and bruising can be increased when Antithrombin Alfa is combined with Hyodeoxycholic Acid. |
| Edoxaban | The risk or severity of bleeding can be increased when Edoxaban is combined with Antithrombin Alfa. |
| Ibrutinib | The risk or severity of bleeding and hemorrhage can be increased when Ibrutinib is combined with Antithrombin Alfa. |
| Obinutuzumab | The risk or severity of bleeding and hemorrhage can be increased when Antithrombin Alfa is combined with Obinutuzumab. |
| Rivaroxaban | Antithrombin Alfa may increase the anticoagulant activities of Rivaroxaban. |
| Sugammadex | The risk or severity of bleeding and hemorrhage can be increased when Antithrombin Alfa is combined with Sugammadex. |
| Tibolone | Tibolone may increase the anticoagulant activities of Antithrombin Alfa. |
| Tipranavir | The risk or severity of bleeding and hemorrhage can be increased when Tipranavir is combined with Antithrombin Alfa. |
| Urokinase | Urokinase may increase the anticoagulant activities of Antithrombin Alfa. |
| Vitamin E | Vitamin E may increase the anticoagulant activities of Antithrombin Alfa. |
| Vorapaxar | The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Antithrombin Alfa. |
| Ginkgo biloba | Ginkgo biloba may increase the anticoagulant activities of Antithrombin Alfa. |
| Ifosfamide | The risk or severity of bleeding can be increased when Ifosfamide is combined with Antithrombin Alfa. |
| Quinine | The therapeutic efficacy of Antithrombin Alfa can be increased when used in combination with Quinine. |
| Quinidine | The therapeutic efficacy of Antithrombin Alfa can be increased when used in combination with Quinidine. |
| Tamoxifen | The risk or severity of bleeding can be increased when Tamoxifen is combined with Antithrombin Alfa. |
| Toremifene | The risk or severity of bleeding can be increased when Toremifene is combined with Antithrombin Alfa. |
| Pentoxifylline | The therapeutic efficacy of Antithrombin Alfa can be increased when used in combination with Pentoxifylline. |
| Pentosan polysulfate | Pentosan polysulfate may increase the anticoagulant activities of Antithrombin Alfa. |
| Levocarnitine | The therapeutic efficacy of Antithrombin Alfa can be increased when used in combination with Levocarnitine. |
| Diethylstilbestrol | Diethylstilbestrol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Chlorotrianisene | Chlorotrianisene may decrease the anticoagulant activities of Antithrombin Alfa. |
| Conjugated estrogens | Conjugated estrogens may decrease the anticoagulant activities of Antithrombin Alfa. |
| Mestranol | The risk or severity of adverse effects can be increased when Mestranol is combined with Antithrombin Alfa. |
| Estrone sulfate | Estrone sulfate may decrease the anticoagulant activities of Antithrombin Alfa. |
| Quinestrol | Quinestrol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Hexestrol | Hexestrol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Synthetic Conjugated Estrogens, A | Synthetic Conjugated Estrogens, A may decrease the anticoagulant activities of Antithrombin Alfa. |
| Synthetic Conjugated Estrogens, B | Synthetic Conjugated Estrogens, B may decrease the anticoagulant activities of Antithrombin Alfa. |
| Polyestradiol phosphate | Polyestradiol phosphate may decrease the anticoagulant activities of Antithrombin Alfa. |
| Esterified estrogens | Esterified estrogens may decrease the anticoagulant activities of Antithrombin Alfa. |
| Zeranol | Zeranol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Equol | Equol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Methallenestril | Methallenestril may decrease the anticoagulant activities of Antithrombin Alfa. |
| Epimestrol | Epimestrol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Moxestrol | Moxestrol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Estradiol acetate | Estradiol acetate may decrease the anticoagulant activities of Antithrombin Alfa. |
| Estradiol benzoate | Estradiol benzoate may decrease the anticoagulant activities of Antithrombin Alfa. |
| Estradiol cypionate | Estradiol cypionate may decrease the anticoagulant activities of Antithrombin Alfa. |
| Estradiol valerate | Estradiol valerate may decrease the anticoagulant activities of Antithrombin Alfa. |
| Biochanin A | Biochanin A may decrease the anticoagulant activities of Antithrombin Alfa. |
| Formononetin | Formononetin may decrease the anticoagulant activities of Antithrombin Alfa. |
| Estriol | Estriol may decrease the anticoagulant activities of Antithrombin Alfa. |
| Limaprost | The risk or severity of adverse effects can be increased when Limaprost is combined with Antithrombin Alfa. |
| Icosapent | The risk or severity of bleeding and hemorrhage can be increased when Icosapent is combined with Antithrombin Alfa. |
| Mesalazine | The risk or severity of bleeding can be increased when Mesalazine is combined with Antithrombin Alfa. |
| Indomethacin | The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Antithrombin Alfa. |
| Nabumetone | The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Antithrombin Alfa. |
| Ketorolac | The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Antithrombin Alfa. |
| Tenoxicam | The risk or severity of bleeding and hemorrhage can be increased when Tenoxicam is combined with Antithrombin Alfa. |
| Celecoxib | The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Antithrombin Alfa. |
| Tolmetin | The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Antithrombin Alfa. |
| Rofecoxib | The risk or severity of bleeding and hemorrhage can be increased when Rofecoxib is combined with Antithrombin Alfa. |
| Piroxicam | The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Antithrombin Alfa. |
| Fenoprofen | The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Antithrombin Alfa. |
| Valdecoxib | The risk or severity of bleeding and hemorrhage can be increased when Valdecoxib is combined with Antithrombin Alfa. |
| Diclofenac | The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Antithrombin Alfa. |
| Sulindac | The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Antithrombin Alfa. |
| Flurbiprofen | The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Antithrombin Alfa. |
| Etodolac | The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Antithrombin Alfa. |
| Mefenamic acid | The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Antithrombin Alfa. |
| Naproxen | The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Antithrombin Alfa. |
| Sulfasalazine | The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Antithrombin Alfa. |
| Phenylbutazone | The risk or severity of bleeding and hemorrhage can be increased when Phenylbutazone is combined with Antithrombin Alfa. |
| Meloxicam | The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Antithrombin Alfa. |
| Carprofen | The risk or severity of bleeding and hemorrhage can be increased when Carprofen is combined with Antithrombin Alfa. |
| Diflunisal | The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Antithrombin Alfa. |
| Salicylic acid | The risk or severity of bleeding and hemorrhage can be increased when Salicylic acid is combined with Antithrombin Alfa. |
| Meclofenamic acid | The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Antithrombin Alfa. |
| Oxaprozin | The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Antithrombin Alfa. |
| Ketoprofen | The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Antithrombin Alfa. |
| Balsalazide | The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Antithrombin Alfa. |
| Olsalazine | The risk or severity of bleeding can be increased when Olsalazine is combined with Antithrombin Alfa. |
| Lumiracoxib | The risk or severity of bleeding and hemorrhage can be increased when Lumiracoxib is combined with Antithrombin Alfa. |
| Magnesium salicylate | The risk or severity of bleeding and hemorrhage can be increased when Magnesium salicylate is combined with Antithrombin Alfa. |
| Salsalate | The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Antithrombin Alfa. |
| Choline magnesium trisalicylate | The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Antithrombin Alfa. |
| Antrafenine | The risk or severity of bleeding and hemorrhage can be increased when Antrafenine is combined with Antithrombin Alfa. |
| Aminophenazone | The risk or severity of bleeding and hemorrhage can be increased when Aminophenazone is combined with Antithrombin Alfa. |
| Antipyrine | The risk or severity of bleeding and hemorrhage can be increased when Antipyrine is combined with Antithrombin Alfa. |
| Tiaprofenic acid | The risk or severity of bleeding and hemorrhage can be increased when Tiaprofenic acid is combined with Antithrombin Alfa. |
| Etoricoxib | The risk or severity of bleeding and hemorrhage can be increased when Etoricoxib is combined with Antithrombin Alfa. |
| Taxifolin | The risk or severity of bleeding and hemorrhage can be increased when Taxifolin is combined with Antithrombin Alfa. |
| Oxyphenbutazone | The risk or severity of bleeding and hemorrhage can be increased when Oxyphenbutazone is combined with Antithrombin Alfa. |