Peringatan Keamanan

Some adverse effects experienced in patients include gastrointestinal disturbances such as vomiting and constipation, metabolic disorders and skin reactions.

Omega-3 fatty acids

DB11133

small molecule approved nutraceutical

Deskripsi

Omega-3 fatty acids are polyunsaturated fatty acids (PUFAs) with a double bond at the third carbon atom from the end of the carbon chain. The three types of omega-3 fatty acids involved in human physiology are ?-linolenic acid (ALA) (found in plant oils), eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) (both commonly found in fish oil that originally come from microalgae that is further consumed by phytoplankton, a source of diet for fish). Omega-3 fatty acids play a critical role in metabolism and cellular function and they are available as daily supplements. On September 8, 2004, the U.S. Food and Drug Administration gave "qualified health claim" status to EPA and DHA omega-3 fatty acids. Therapeutic products containing omega-3 fatty acid and its derivatives for treatment of hypertriglyceridemia include Lovaza, Omtryg, Epanova, and Vascepa.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Approximate half-life values in a compartmental study of ALA, EPA and DHA are 1h, 39-67h and 20h, respectively [A19369, A19370].
Volume Distribusi Vd of EPA is aproximately 82L
Klirens (Clearance) Clearance of EPA is approximately 757mL/h [A18890].

Absorpsi

After ingestion, dietary lipids are hydrolyzed in the intestinal lumen. The hydrolysis products—monoglycerides and free fatty acids—are then incorporated into bile-salt– containing micelles and absorbed into enterocytes, largely by passive diffusion. The absorption rate is about 95%. Within intestinal cells, free fatty acids are primarily incorporated into chylomicrons and enter the circulation via the lymphatic system where they are delivered to various tissues for metabolism, oxidation and storage.

Metabolisme

ALA, DHA and EPA are metabolized and oxidized in the liver, which is the site of biosynthesis of n-3 fatty acid intermediates, synthesizing VLDL that transport fatty acids in the plasma to tissues. Major enzymes that generate lipid signalling molecules from EPA, DHA and ALA are lipoxygenases and cyclooxygenase.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

117 Data
Ibrutinib Omega-3 fatty acids may increase the antiplatelet activities of Ibrutinib.
Lepirudin Omega-3 fatty acids may increase the anticoagulant activities of Lepirudin.
Bivalirudin Omega-3 fatty acids may increase the anticoagulant activities of Bivalirudin.
Alteplase Omega-3 fatty acids may increase the anticoagulant activities of Alteplase.
Urokinase Omega-3 fatty acids may increase the anticoagulant activities of Urokinase.
Reteplase Omega-3 fatty acids may increase the anticoagulant activities of Reteplase.
Anistreplase Omega-3 fatty acids may increase the anticoagulant activities of Anistreplase.
Tenecteplase Omega-3 fatty acids may increase the anticoagulant activities of Tenecteplase.
Drotrecogin alfa Omega-3 fatty acids may increase the anticoagulant activities of Drotrecogin alfa.
Streptokinase Omega-3 fatty acids may increase the anticoagulant activities of Streptokinase.
Dicoumarol Omega-3 fatty acids may increase the anticoagulant activities of Dicoumarol.
Argatroban Omega-3 fatty acids may increase the anticoagulant activities of Argatroban.
Ardeparin Omega-3 fatty acids may increase the anticoagulant activities of Ardeparin.
Phenindione Omega-3 fatty acids may increase the anticoagulant activities of Phenindione.
Fondaparinux Omega-3 fatty acids may increase the anticoagulant activities of Fondaparinux.
Warfarin Omega-3 fatty acids may increase the anticoagulant activities of Warfarin.
Pentosan polysulfate Omega-3 fatty acids may increase the anticoagulant activities of Pentosan polysulfate.
Phenprocoumon Omega-3 fatty acids may increase the anticoagulant activities of Phenprocoumon.
Heparin Omega-3 fatty acids may increase the anticoagulant activities of Heparin.
Enoxaparin Omega-3 fatty acids may increase the anticoagulant activities of Enoxaparin.
Acenocoumarol Omega-3 fatty acids may increase the anticoagulant activities of Acenocoumarol.
4-hydroxycoumarin Omega-3 fatty acids may increase the anticoagulant activities of 4-hydroxycoumarin.
Coumarin Omega-3 fatty acids may increase the anticoagulant activities of Coumarin.
Ximelagatran Omega-3 fatty acids may increase the anticoagulant activities of Ximelagatran.
Desmoteplase Omega-3 fatty acids may increase the anticoagulant activities of Desmoteplase.
Ancrod Omega-3 fatty acids may increase the anticoagulant activities of Ancrod.
Rivaroxaban Omega-3 fatty acids may increase the anticoagulant activities of Rivaroxaban.
Sulodexide Omega-3 fatty acids may increase the anticoagulant activities of Sulodexide.
Semuloparin Omega-3 fatty acids may increase the anticoagulant activities of Semuloparin.
Idraparinux Omega-3 fatty acids may increase the anticoagulant activities of Idraparinux.
Astaxanthin Omega-3 fatty acids may increase the anticoagulant activities of Astaxanthin.
Apixaban Omega-3 fatty acids may increase the anticoagulant activities of Apixaban.
Otamixaban Omega-3 fatty acids may increase the anticoagulant activities of Otamixaban.
Amediplase Omega-3 fatty acids may increase the anticoagulant activities of Amediplase.
Dabigatran etexilate Omega-3 fatty acids may increase the anticoagulant activities of Dabigatran etexilate.
Danaparoid Omega-3 fatty acids may increase the anticoagulant activities of Danaparoid.
Dalteparin Omega-3 fatty acids may increase the anticoagulant activities of Dalteparin.
Tinzaparin Omega-3 fatty acids may increase the anticoagulant activities of Tinzaparin.
(R)-warfarin Omega-3 fatty acids may increase the anticoagulant activities of (R)-warfarin.
Ethyl biscoumacetate Omega-3 fatty acids may increase the anticoagulant activities of Ethyl biscoumacetate.
Nadroparin Omega-3 fatty acids may increase the anticoagulant activities of Nadroparin.
Ditazole Omega-3 fatty acids may increase the anticoagulant activities of Ditazole.
Edoxaban Omega-3 fatty acids may increase the anticoagulant activities of Edoxaban.
Sodium citrate Omega-3 fatty acids may increase the anticoagulant activities of Sodium citrate.
Dextran Omega-3 fatty acids may increase the anticoagulant activities of Dextran.
Bemiparin Omega-3 fatty acids may increase the anticoagulant activities of Bemiparin.
Parnaparin Omega-3 fatty acids may increase the anticoagulant activities of Parnaparin.
Desirudin Omega-3 fatty acids may increase the anticoagulant activities of Desirudin.
Antithrombin Alfa Omega-3 fatty acids may increase the anticoagulant activities of Antithrombin Alfa.
Protein C Omega-3 fatty acids may increase the anticoagulant activities of Protein C.
Antithrombin III human Omega-3 fatty acids may increase the anticoagulant activities of Antithrombin III human.
Letaxaban Omega-3 fatty acids may increase the anticoagulant activities of Letaxaban.
Darexaban Omega-3 fatty acids may increase the anticoagulant activities of Darexaban.
Betrixaban Omega-3 fatty acids may increase the anticoagulant activities of Betrixaban.
Nafamostat Omega-3 fatty acids may increase the anticoagulant activities of Nafamostat.
Monteplase Omega-3 fatty acids may increase the anticoagulant activities of Monteplase.
Gabexate Omega-3 fatty acids may increase the anticoagulant activities of Gabexate.
Fluindione Omega-3 fatty acids may increase the anticoagulant activities of Fluindione.
Protein S human Omega-3 fatty acids may increase the anticoagulant activities of Protein S human.
Brinase Omega-3 fatty acids may increase the anticoagulant activities of Brinase.
Clorindione Omega-3 fatty acids may increase the anticoagulant activities of Clorindione.
Diphenadione Omega-3 fatty acids may increase the anticoagulant activities of Diphenadione.
Tioclomarol Omega-3 fatty acids may increase the anticoagulant activities of Tioclomarol.
Melagatran Omega-3 fatty acids may increase the anticoagulant activities of Melagatran.
Saruplase Omega-3 fatty acids may increase the anticoagulant activities of Saruplase.
(S)-Warfarin Omega-3 fatty acids may increase the anticoagulant activities of (S)-Warfarin.
Tocopherylquinone Omega-3 fatty acids may increase the anticoagulant activities of Tocopherylquinone.
Dabigatran Omega-3 fatty acids may increase the anticoagulant activities of Dabigatran.
Troxerutin Omega-3 fatty acids may increase the anticoagulant activities of Troxerutin.
Edetic acid Omega-3 fatty acids may increase the anticoagulant activities of Edetic acid.
Reviparin Omega-3 fatty acids may increase the anticoagulant activities of Reviparin.
Dermatan sulfate Omega-3 fatty acids may increase the anticoagulant activities of Dermatan sulfate.
SR-123781A Omega-3 fatty acids may increase the anticoagulant activities of SR-123781A.
Abciximab Omega-3 fatty acids may increase the antiplatelet activities of Abciximab.
Eptifibatide Omega-3 fatty acids may increase the antiplatelet activities of Eptifibatide.
Ticlopidine Omega-3 fatty acids may increase the antiplatelet activities of Ticlopidine.
Anagrelide Omega-3 fatty acids may increase the antiplatelet activities of Anagrelide.
Clopidogrel Omega-3 fatty acids may increase the antiplatelet activities of Clopidogrel.
Tirofiban Omega-3 fatty acids may increase the antiplatelet activities of Tirofiban.
Pentoxifylline Omega-3 fatty acids may increase the antiplatelet activities of Pentoxifylline.
Acetylsalicylic acid Omega-3 fatty acids may increase the antiplatelet activities of Acetylsalicylic acid.
Dipyridamole Omega-3 fatty acids may increase the antiplatelet activities of Dipyridamole.
Sulfinpyrazone Omega-3 fatty acids may increase the antiplatelet activities of Sulfinpyrazone.
Cilostazol Omega-3 fatty acids may increase the antiplatelet activities of Cilostazol.
Ridogrel Omega-3 fatty acids may increase the antiplatelet activities of Ridogrel.
Epoprostenol Omega-3 fatty acids may increase the antiplatelet activities of Epoprostenol.
Resveratrol Omega-3 fatty acids may increase the antiplatelet activities of Resveratrol.
Nimesulide Omega-3 fatty acids may increase the antiplatelet activities of Nimesulide.
Tesmilifene Omega-3 fatty acids may increase the antiplatelet activities of Tesmilifene.
Defibrotide Omega-3 fatty acids may increase the antiplatelet activities of Defibrotide.
Beraprost Omega-3 fatty acids may increase the antiplatelet activities of Beraprost.
Ibudilast Omega-3 fatty acids may increase the antiplatelet activities of Ibudilast.
Andrographolide Omega-3 fatty acids may increase the antiplatelet activities of Andrographolide.
Caplacizumab Omega-3 fatty acids may increase the antiplatelet activities of Caplacizumab.
Prasugrel Omega-3 fatty acids may increase the antiplatelet activities of Prasugrel.
Cangrelor Omega-3 fatty acids may increase the antiplatelet activities of Cangrelor.
Tranilast Omega-3 fatty acids may increase the antiplatelet activities of Tranilast.
Triflusal Omega-3 fatty acids may increase the antiplatelet activities of Triflusal.
Ticagrelor Omega-3 fatty acids may increase the antiplatelet activities of Ticagrelor.
Icosapent ethyl Omega-3 fatty acids may increase the antiplatelet activities of Icosapent ethyl.

Target Protein

Peroxisome proliferator-activated receptor gamma PPARG
Peroxisome proliferator-activated receptor alpha PPARA
Sterol regulatory element-binding protein 1 SREBF1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22254027
    Calder PC: Omega-3 fatty acids and inflammatory processes. Nutrients. 2010 Mar;2(3):355-74. doi: 10.3390/nu2030355. Epub 2010 Mar 18.
  • PMID: 21884130
    Mahaffey KR, Sunderland EM, Chan HM, Choi AL, Grandjean P, Marien K, Oken E, Sakamoto M, Schoeny R, Weihe P, Yan CH, Yasutake A: Balancing the benefits of n-3 polyunsaturated fatty acids and the risks of methylmercury exposure from fish consumption. Nutr Rev. 2011 Sep;69(9):493-508. doi: 10.1111/j.1753-4887.2011.00415.x.
  • PMID: 26681905
    Ito MK: A Comparative Overview of Prescription Omega-3 Fatty Acid Products. P T. 2015 Dec;40(12):826-57.
  • PMID: 26740832
    Forbes SC, Holroyd-Leduc JM, Poulin MJ, Hogan DB: Effect of Nutrients, Dietary Supplements and Vitamins on Cognition: a Systematic Review and Meta-Analysis of Randomized Controlled Trials. Can Geriatr J. 2015 Dec 23;18(4):231-45. doi: 10.5770/cgj.18.189. eCollection 2015 Dec.
  • PMID: 27063583
    Burckhardt M, Herke M, Wustmann T, Watzke S, Langer G, Fink A: Omega-3 fatty acids for the treatment of dementia. Cochrane Database Syst Rev. 2016 Apr 11;4:CD009002. doi: 10.1002/14651858.CD009002.pub3.
  • PMID: 1387231
    Marsen TA, Pollok M, Oette K, Baldamus CA: Pharmacokinetics of omega-3-fatty acids during ingestion of fish oil preparations. Prostaglandins Leukot Essent Fatty Acids. 1992 Jul;46(3):191-6.
  • PMID: 23471029
    Dobson EP, Barrow CJ, Kralovec JA, Adcock JL: Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase. J Lipid Res. 2013 May;54(5):1439-47. doi: 10.1194/jlr.M036186. Epub 2013 Mar 7.
  • PMID: 11483627
    Pawlosky RJ, Hibbeln JR, Novotny JA, Salem N Jr: Physiological compartmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res. 2001 Aug;42(8):1257-65.
Menampilkan 8 dari 12 artikel.
Textbook
  • ISBN: 978-0-7020-3471-8
    23. (2012). In Rang and Dale's Pharmacology (7th ed., pp. 291-2). Edinburgh: Elsevier/Churchill Livingstone.

Contoh Produk & Brand

Produk: 66 • International brands: 0
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    Capsule; Kit; Tablet, film coated • - • Oral • US
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  • Bal-Care DHA
    Kit • - • Oral • US
  • Bal-Care DHA Essential
    Kit • - • Oral • US
  • BP Vit 3
    Capsule, coated • - • Oral • US
  • BumP DHA
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