Peringatan Keamanan

Oral LD50 in rat is >2000 mg/kg MSDS.

Carbamide peroxide

DB11129

small molecule approved

Deskripsi

Carbamide peroxide, also known as urea-hydrogen peroxide, is a water-soluble, white crystalline solid compound consisting of hydrogen peroxide and urea. As it is a source of hydrogen peroxide, it can be found in disinfecting and dental bleaching products. Some adverse effects of carbamide peroxide as a dental bleaching agent include dentin sensitivity and/or gingival irritation led by unstable and reactive H+ free radicals and low pH from prolonged use. It may also alter enamel surface morphology via enamel mineral loss and surface roughening A32336. The FDA considers carbamide peroxide to be safe in oral mucosal injury drug products as an oral wound healing agent, although there is insufficient data to establish general recognition of the effectiveness of this ingredient as an oral wound healing agent L1976. It is available in OTC otic drugs as non-water, non-oil-based solutions used to soften, loosen and remove excessive ear wax, or cerumen.

Struktur Molekul 2D

Berat 94.07
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No established pharmacokinetic data.
Volume Distribusi No established pharmacokinetic data.
Klirens (Clearance) No established pharmacokinetic data.

Absorpsi

Upon treatment into the external auditory canal or the dental cavity, exposure to carbamide peroxide is limited to the intimate contact with the treated area without any systemic absorption.

Metabolisme

No established pharmacokinetic data.

Rute Eliminasi

No established pharmacokinetic data.

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 22031060
    Ourique SA, Arrais CA, Cassoni A, Ota-Tsuzuki C, Rodrigues JA: Effects of different concentrations of carbamide peroxide and bleaching periods on the roughness of dental ceramics. Braz Oral Res. 2011 Sep-Oct;25(5):453-8.
  • PMID: 22666835
    Meireles SS, Fontes ST, Coimbra LA, Della Bona A, Demarco FF: Effectiveness of different carbamide peroxide concentrations used for tooth bleaching: an in vitro study. J Appl Oral Sci. 2012 Mar-Apr;20(2):186-91.
  • PMID: 25254197
    Bollineni S, Janga RK, Venugopal L, Reddy IR, Babu PR, Kumar SS: Role of fluoridated carbamide peroxide whitening gel in the remineralization of demineralized enamel: An in vitro study. J Int Soc Prev Community Dent. 2014 May;4(2):117-21. doi: 10.4103/2231-0762.137638.
  • PMID: 15527615
    Hand C, Harvey I: The effectiveness of topical preparations for the treatment of earwax: a systematic review. Br J Gen Pract. 2004 Nov;54(508):862-7.

Contoh Produk & Brand

Produk: 150 • International brands: 11
Produk
  • Audiologists Choice Earwax Removal Aid Drops
    Solution / drops • 65 mg/1mL • Auricular (otic) • US • OTC
  • Audiologists Choice Earwax Removal System
    Liquid • 65 mg/1mL • Topical • US • OTC
  • Auralyt
    Liquid • 7.8 mg/12mL • Topical • US • OTC
  • Auro Ear Wax Remover
    Liquid • 1.44 mL/22mL • Auricular (otic) • US • OTC
  • Best Choice Earwax Removal Drops
    Solution / drops • 65 mg/1mL • Auricular (otic) • US • OTC
  • Best Choice Earwax Removal Kit
    Liquid • 65 mg/1mL • Topical • US • OTC
  • CareOne Earwax Removal Drops
    Solution / drops • 65 mg/1mL • Auricular (otic) • US • OTC
  • CareOne Earwax Removal Kit, Earwax and Bulb
    Kit • 65 mg/1mL • Auricular (otic) • US • OTC
Menampilkan 8 dari 150 produk.
International Brands
  • Aquadrate
  • Balneum plus
  • Calmurid
  • Eucerin
  • Flexifoot
  • Flexitol
  • Hydromol intensive
  • Nutraplus
  • Sential E
  • St.James balm

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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