Peringatan Keamanan

Infants : LDLo (Intramuscular ) : 10gm/kg ; Effects - Brain and coverings : meningeal changes
Infants : TDLo ( Intramuscular ) : 143 mg/kg ; Effects - Dermatits
Mouse: LD50 ( intravenous ) : 950mg/kg
Mouse : LDLo (Oral ) : 10gm/kg

Calcium gluconate

DB11126

small molecule approved vet_approved

Deskripsi

Calcium gluconate is used as mineral supplement and medication when there is insufficient calcium in the diet. Supplementation may be done to treat or prevent osteoporosis or rickets, consequences of hypocalcemia. It can also be taken by mouth but is not recommended by injection into a muscle.
Calcium Gluconate Injection, USP is a sterile, nonpyrogenic supersaturated solution of calcium gluconate for intravenous use only. Each mL contains: Calcium gluconate 94 mg; calcium saccharate (tetrahydrate) 4.5 mg; water for injection q.s. Hydrochloric acid and/or sodium hydroxide may have been added for pH adjustment (6.0 to 8.2). Calcium saccharate provides 6% of the total calcium and stabilizes the supersaturated solution of calcium gluconate.
Each 10 mL of the injection provides 93 mg elemental calcium (Ca++) equivalent to 1 g of calcium gluconate.

Struktur Molekul 2D

Berat 430.372
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi Not available
Klirens (Clearance) -

Absorpsi

Approximately one-fifth to one-third of orally administered calcium is absorbed in the small intestine, depending on presence of vitamin D metabolites, pH in lumen, and on dietary factors, such as calcium binding to fiber or phytates. Calcium absorption is increased when a calcium deficiency is present or when a patient is on a low-calcium diet. In patients with achlorhydria or hypochlorhydria, calcium absorption, especially with the carbonate salt, may be reduced.

Metabolisme

Calcium gluconate does not require hepatic metabolism for the release of Ca++ and is as effective as calcium chloride in treating ionic hypocalcemia in the absence of hepatic function.

Rute Eliminasi

Renal (20%) - The amount excreted in the urine varies with degree of calcium absorption and whether there is excessive bone loss or failure of renal conservation. Fecal (80%) - Consists mainly of nonabsorbed calcium, with only a small amount of endogenous fecal calcium excreted.

Interaksi Makanan

2 Data
  • 1. Take with a full glass of water.
  • 2. Take with food.

Interaksi Obat

228 Data
Grepafloxacin Calcium gluconate can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enoxacin Calcium gluconate can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pefloxacin Calcium gluconate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofloxacin Calcium gluconate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trovafloxacin Calcium gluconate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalidixic acid Calcium gluconate can cause a decrease in the absorption of Nalidixic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosoxacin Calcium gluconate can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin Calcium gluconate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lomefloxacin Calcium gluconate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gatifloxacin Calcium gluconate can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norfloxacin Calcium gluconate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemifloxacin Calcium gluconate can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Calcium gluconate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sparfloxacin Calcium gluconate can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temafloxacin Calcium gluconate can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fleroxacin Calcium gluconate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m ciprofloxacin Calcium gluconate can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Garenoxacin Calcium gluconate can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nemonoxacin Calcium gluconate can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Flumequine Calcium gluconate can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enrofloxacin Calcium gluconate can cause a decrease in the absorption of Enrofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orbifloxacin Calcium gluconate can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarafloxacin Calcium gluconate can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Difloxacin Calcium gluconate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pazufloxacin Calcium gluconate can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prulifloxacin Calcium gluconate can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delafloxacin Calcium gluconate can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sitafloxacin Calcium gluconate can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxolinic acid Calcium gluconate can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rufloxacin Calcium gluconate can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pipemidic acid Calcium gluconate can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ceftriaxone The risk or severity of adverse effects can be increased when Calcium gluconate is combined with Ceftriaxone.
Deferiprone The serum concentration of Deferiprone can be decreased when it is combined with Calcium gluconate.
Dobutamine The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium gluconate.
Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Calcium gluconate.
Eltrombopag The serum concentration of Eltrombopag can be decreased when it is combined with Calcium gluconate.
Estramustine Calcium gluconate can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate The risk or severity of adverse effects can be increased when Calcium gluconate is combined with Calcium acetate.
Digoxin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Digoxin.
Acetyldigitoxin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Deslanoside Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Deslanoside.
Ouabain Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Ouabain.
Digitoxin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Digitoxin.
Oleandrin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Oleandrin.
Cymarin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Cymarin.
Proscillaridin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Proscillaridin.
Metildigoxin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Metildigoxin.
Lanatoside C Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Lanatoside C.
Gitoformate Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Gitoformate.
Acetyldigoxin Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigoxin.
Peruvoside Calcium gluconate may increase the arrhythmogenic and cardiotoxic activities of Peruvoside.
Strontium ranelate The serum concentration of Strontium ranelate can be decreased when it is combined with Calcium gluconate.
Doxycycline The serum concentration of Doxycycline can be decreased when it is combined with Calcium gluconate.
Lymecycline The serum concentration of Lymecycline can be decreased when it is combined with Calcium gluconate.
Clomocycline The serum concentration of Clomocycline can be decreased when it is combined with Calcium gluconate.
Oxytetracycline The serum concentration of Oxytetracycline can be decreased when it is combined with Calcium gluconate.
Demeclocycline The serum concentration of Demeclocycline can be decreased when it is combined with Calcium gluconate.
Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Calcium gluconate.
Metacycline The serum concentration of Metacycline can be decreased when it is combined with Calcium gluconate.
Minocycline The serum concentration of Minocycline can be decreased when it is combined with Calcium gluconate.
Sarecycline The serum concentration of Sarecycline can be decreased when it is combined with Calcium gluconate.
Omadacycline The serum concentration of Omadacycline can be decreased when it is combined with Calcium gluconate.
Penimepicycline The serum concentration of Penimepicycline can be decreased when it is combined with Calcium gluconate.
Methyclothiazide Methyclothiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Chlorthalidone Chlorthalidone may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Bendroflumethiazide Bendroflumethiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Metolazone Metolazone may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Benzthiazide Benzthiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Hydroflumethiazide Hydroflumethiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Indapamide Indapamide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Chlorothiazide Chlorothiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Trichlormethiazide Trichlormethiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Polythiazide Polythiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Quinethazone Quinethazone may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Cyclopenthiazide Cyclopenthiazide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Epitizide Epitizide may decrease the excretion rate of Calcium gluconate which could result in a higher serum level.
Triethylenetetramine Calcium gluconate can cause a decrease in the absorption of Triethylenetetramine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol The risk or severity of adverse effects can be increased when Calcitriol is combined with Calcium gluconate.
Calcifediol The risk or severity of adverse effects can be increased when Calcifediol is combined with Calcium gluconate.
Paricalcitol The risk or severity of adverse effects can be increased when Paricalcitol is combined with Calcium gluconate.
Dihydrotachysterol The risk or severity of adverse effects can be increased when Dihydrotachysterol is combined with Calcium gluconate.
Alfacalcidol The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium gluconate.
Calcipotriol The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium gluconate.
Seocalcitol The risk or severity of adverse effects can be increased when Seocalcitol is combined with Calcium gluconate.
Inecalcitol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium gluconate.
Becocalcidiol The risk or severity of adverse effects can be increased when Becocalcidiol is combined with Calcium gluconate.
Eldecalcitol The risk or severity of adverse effects can be increased when Eldecalcitol is combined with Calcium gluconate.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of adverse effects can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Calcium gluconate.
Elocalcitol The risk or severity of adverse effects can be increased when Elocalcitol is combined with Calcium gluconate.
Maxacalcitol The risk or severity of adverse effects can be increased when Maxacalcitol is combined with Calcium gluconate.
Doxercalciferol The risk or severity of adverse effects can be increased when Doxercalciferol is combined with Calcium gluconate.
1alpha-Hydroxyvitamin D5 The risk or severity of adverse effects can be increased when 1alpha-Hydroxyvitamin D5 is combined with Calcium gluconate.
Tacalcitol The risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium gluconate.
Previtamin D(3) The risk or severity of adverse effects can be increased when Previtamin D(3) is combined with Calcium gluconate.
Isradipine The therapeutic efficacy of Isradipine can be decreased when used in combination with Calcium gluconate.
Diltiazem The therapeutic efficacy of Diltiazem can be decreased when used in combination with Calcium gluconate.
Trimethadione The therapeutic efficacy of Trimethadione can be decreased when used in combination with Calcium gluconate.
Amlodipine The therapeutic efficacy of Amlodipine can be decreased when used in combination with Calcium gluconate.
Nimodipine The therapeutic efficacy of Nimodipine can be decreased when used in combination with Calcium gluconate.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 2360741
    Martin TJ, Kang Y, Robertson KM, Virji MA, Marquez JM: Ionization and hemodynamic effects of calcium chloride and calcium gluconate in the absence of hepatic function. Anesthesiology. 1990 Jul;73(1):62-5.

Contoh Produk & Brand

Produk: 69 • International brands: 0
Produk
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    Solution • 20 mg / mL • Intravenous • Canada • Approved
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    Injection, solution • 94 mg/1mL • Intravenous • US
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  • Calcium Gluconate
    Injection, solution • 94 mg/1mL • Intravenous • US
  • Calcium Gluconate
    Injection, solution • 94 mg/1mL • Intravenous • US
  • Calcium Gluconate
    Injection, solution • 94 mg/1mL • Intravenous • US
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Menampilkan 8 dari 69 produk.

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