Acute oral LD50 is 295 mg/kg in rat MSDS. Benzethonium was not shown to be mutagenic in the AMES Test MSDS. In a rat dermal study, there was no evidence of carcinogenic or genotoxic potential A32304.
Benzethonium is toxic when orally ingested with 1 g reported to be fatal. The risk of toxicity is related to concentration with cationic detergents. Ingestion may lead to diarrhea, abdominal pain, vomiting, collapse, convulsions, coma L1923. Oral exposure to high concentrations of benzethonium may lead to burns of the mouth, pharynx, and esophagus. To a rarer extent, hemorrhagic gastrointestinal (GI) tract necrosis and peritonitis, bronchospasm, aspiration pneumonitis, hypoxemia, and acute lung injury may develop. CNS depression progressing to coma and shock have been observed with severe ingestion or corrosive GI injury with parenteral administration of cationic detergents L1923.
Benzethonium is a synthetic quaternary ammonium salt with surfactant, antiseptic, and broad spectrum antimicrobial properties. Its salt form, benzethonium chloride, is primarily used as a skin disinfectant at concentrations of 0.1-0.2 %, which are safe and effective concentrations for the compound specified by the U.S. Food and Drug Administration (FDA). It is additionally found in cosmetics and toiletries such as mouthwashes and anti-itch ointments. It is shown to be effective in mediating its antimicrobial action against bacteria, fungi, mold and viruses. There is evidence that benzethonium acts as a spermatocide but may cause vaginal irritation A32304. Benzethonium was identified as a novel cancer-specific compound by cell-based small-molecule screen A32298.
Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).
drugbank-id dan name pada skema XML DrugBank.targets/target yang memuat polipeptida sasaran.gene-name dan varian snp-effects.Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.