Peringatan Keamanan

Human : TCLo ( Inhalation) 175ppm, Effects : lung, Thorax or Respiration
Human: TCLo ( inhalation ) 6gm/m3/3h , Effects : Behavioral: Headache
Infant: LDLo ( Oral ) 1748 mg/kg, Effect : GI, Nausea or vomiting
Man: LDLo (Oral ) 3mg/kg
Mouse LC50 ( inhalation ) 29mg/m3/2h
Mouse: LD50 ( intravenous ) 1180ug/kg
Rabbit: LDLo ( Skin) 5010mg/kg, Effect: general depressed activity

Turpentine

DB11120

small molecule approved experimental

Deskripsi

Turpentine, also known as spirit of turpentine, oil of turpentine, and wood turpentine, is a liquid extracted from live trees, mainly pine, through distillation of resin. It is used as a solvent and base material in organic synthesis reactions. Turpentine is composed of terpenes, mainly the monoterpenes alpha-pinene and beta-pinene with lesser amounts of carene, camphene, dipentene, and terpinolene.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) Eight male volunteers were exposed to 450 mg/cu m turpentine by inhalation (2 hr, 50 W) in an exposure chamber. The mean half lives of the last phase of alpha-pinene, beta-pinene, and 3-carene (components of turpentine) averaged 32, 25, and 42 hours, respectively.

Volume Distribusi Turpentine, as a lipophilic substance, accumulates in fatty tissues. The highest concentrations of turpentine following inhalation by rats were found in the spleen, kidneys, brain, and peripheral and perinephric fat.

Klirens (Clearance) -

Absorpsi

Turpentine is readily absorbed from GI tract, skin, and respiratory tract.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Elimination of absorbed turpentine in the urine is manifested by an odor resembling that of violets.

Interaksi Obat

0 Data

Tidak ada data.

Target Protein

Mitogen-activated protein kinase 1 MAPK1

Referensi & Sumber

Link

Contoh Produk & Brand

Produk: 19 • International brands: 0

Produk

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Cal Mo Dol Ont

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Cerumol

Solution / drops • - • Auricular (otic) • Canada • OTC • Approved
Chan Yat Hing She Kun Wool Lok Medicated Oil

Oil • - • Topical • US • OTC
Die Da Wan Hua Pain Relieving

Oil • 6 g/100mL • Topical • US • OTC
Double Prawn Rumagon

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Menampilkan 8 dari 19 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.