Peringatan Keamanan

Castor oil is considered minimally toxic when administered orally to humans; the estimated lethal oral dose is 1-2 pints of undiluted oil F76. Findings from a repeat-dose study in mouse report an oral LD50 value of >5000 mg/kg and NOAEL is approximately >2500 mg/kg/day in rat F75. Digestive tract irritation following oral ingestion, skin contact sensitization, and contact dermatitis have been reported for castor oil F70, F76.

Castor oil

DB11113

biotech approved investigational nutraceutical vet_approved

Deskripsi

Castor oil is a vegetable oil obtained by pressing the seeds of the castor oil plant (Ricinus communis L.) mainly cultivated in India, South America, Africa, and China. Castor oil is a rich source of DB02955, which represents up to 90% of the total castor oil content. It also consists up to 4% linoleic, 3% oleic, 1% stearic, and less than 1% linolenic fatty acids A31170. DB02955 has a hydroxyl group that provides a functional group location for various chemical reactions, making it a favourable substance in industrial applications A31170. Castor oil does not contain ricin, which is a natural poison found in the castor oil plant; the toxic lectin remains in the bean pulp following oil isolation F70. Due to its renewability and high versatility in addition to being the only commercial source of a hydroxylated fatty acid A31170, castor oil has been used as a vital raw material for the chemical industry A33045. Castor oil was mainly used in the manufacturing of soaps, lubricants, and coatings A31170. It is an FDA-approved food additive directly added to food products for human consumption. It can also be found in hard candies as a release agent and anti-sticking agent, or supplementary vitamins and mineral oral tablets as an ingredient for protective coatings. Castor oil is found in over-the-counter oral liquids as a stimulant laxative, and is also added in commercial cosmetic, hair, and skincare products.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data available.
Volume Distribusi No pharmacokinetic data available.
Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

After oral ingestion of castor oil, ricinoleic acid is released by lipases in the intestinal lumen and absorbed in the intestine A33043. Findings from the rat study suggest that the absorption of castor oil is inversely related to the administered dose, but the absorption is virtually complete at small doses (4g) F70.

Metabolisme

Castor oil is hydrolyzed to glycerol and ricinoleic acid via pancreatic or intestinal lipase activity F70. Ricinoleic acid is metabolized systemically and the metabolites are excreted F70. Fatty acids are expected to be degraded by pancreatic and intestinal lipase.

Rute Eliminasi

Fecal recovery of radio-labelled castor oil ranged from 11.4% (for 10 g dose of castor oil) to 86.0% (for 44.4 g dose of castor oil) F70.

Interaksi Obat

400 Data
Tramadol The therapeutic efficacy of Castor oil can be decreased when used in combination with Tramadol.
Trospium The therapeutic efficacy of Castor oil can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Castor oil can be decreased when used in combination with Oxyphenonium.
Benzatropine The therapeutic efficacy of Castor oil can be decreased when used in combination with Benzatropine.
Ziprasidone The therapeutic efficacy of Castor oil can be decreased when used in combination with Ziprasidone.
Disopyramide The therapeutic efficacy of Castor oil can be decreased when used in combination with Disopyramide.
Amitriptyline The therapeutic efficacy of Castor oil can be decreased when used in combination with Amitriptyline.
Ipratropium The therapeutic efficacy of Castor oil can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Castor oil can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Castor oil can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Castor oil can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Castor oil can be decreased when used in combination with Buclizine.
Clozapine The therapeutic efficacy of Castor oil can be decreased when used in combination with Clozapine.
Doxylamine The therapeutic efficacy of Castor oil can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Castor oil can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Castor oil can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Castor oil can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Castor oil can be decreased when used in combination with Profenamine.
Promazine The therapeutic efficacy of Castor oil can be decreased when used in combination with Promazine.
Hyoscyamine The therapeutic efficacy of Castor oil can be decreased when used in combination with Hyoscyamine.
Cyproheptadine The therapeutic efficacy of Castor oil can be decreased when used in combination with Cyproheptadine.
Imipramine The therapeutic efficacy of Castor oil can be decreased when used in combination with Imipramine.
Methscopolamine bromide The therapeutic efficacy of Castor oil can be decreased when used in combination with Methscopolamine bromide.
Chlorpromazine The therapeutic efficacy of Castor oil can be decreased when used in combination with Chlorpromazine.
Gallamine triethiodide The therapeutic efficacy of Castor oil can be decreased when used in combination with Gallamine triethiodide.
Darifenacin The therapeutic efficacy of Castor oil can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Castor oil can be decreased when used in combination with Tridihexethyl.
Triflupromazine The therapeutic efficacy of Castor oil can be decreased when used in combination with Triflupromazine.
Anisotropine methylbromide The therapeutic efficacy of Castor oil can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Castor oil can be decreased when used in combination with Nortriptyline.
Amoxapine The therapeutic efficacy of Castor oil can be decreased when used in combination with Amoxapine.
Atropine The therapeutic efficacy of Castor oil can be decreased when used in combination with Atropine.
Nicardipine The therapeutic efficacy of Castor oil can be decreased when used in combination with Nicardipine.
Pirenzepine The therapeutic efficacy of Castor oil can be decreased when used in combination with Pirenzepine.
Paroxetine The therapeutic efficacy of Castor oil can be decreased when used in combination with Paroxetine.
Homatropine methylbromide The therapeutic efficacy of Castor oil can be decreased when used in combination with Homatropine methylbromide.
Rocuronium The therapeutic efficacy of Castor oil can be decreased when used in combination with Rocuronium.
Scopolamine The therapeutic efficacy of Castor oil can be decreased when used in combination with Scopolamine.
Benzquinamide The therapeutic efficacy of Castor oil can be decreased when used in combination with Benzquinamide.
Clidinium The therapeutic efficacy of Castor oil can be decreased when used in combination with Clidinium.
Propiomazine The therapeutic efficacy of Castor oil can be decreased when used in combination with Propiomazine.
Propantheline The therapeutic efficacy of Castor oil can be decreased when used in combination with Propantheline.
Dicyclomine The therapeutic efficacy of Castor oil can be decreased when used in combination with Dicyclomine.
Biperiden The therapeutic efficacy of Castor oil can be decreased when used in combination with Biperiden.
Brompheniramine The therapeutic efficacy of Castor oil can be decreased when used in combination with Brompheniramine.
Flupentixol The therapeutic efficacy of Castor oil can be decreased when used in combination with Flupentixol.
Cocaine The therapeutic efficacy of Castor oil can be decreased when used in combination with Cocaine.
Quinidine The therapeutic efficacy of Castor oil can be decreased when used in combination with Quinidine.
Maprotiline The therapeutic efficacy of Castor oil can be decreased when used in combination with Maprotiline.
Methantheline The therapeutic efficacy of Castor oil can be decreased when used in combination with Methantheline.
Cycrimine The therapeutic efficacy of Castor oil can be decreased when used in combination with Cycrimine.
Glycopyrronium The therapeutic efficacy of Castor oil can be decreased when used in combination with Glycopyrronium.
Tolterodine The therapeutic efficacy of Castor oil can be decreased when used in combination with Tolterodine.
Oxybutynin The therapeutic efficacy of Castor oil can be decreased when used in combination with Oxybutynin.
Promethazine The therapeutic efficacy of Castor oil can be decreased when used in combination with Promethazine.
Diphenhydramine The therapeutic efficacy of Castor oil can be decreased when used in combination with Diphenhydramine.
Doxacurium The therapeutic efficacy of Castor oil can be decreased when used in combination with Doxacurium.
Doxepin The therapeutic efficacy of Castor oil can be decreased when used in combination with Doxepin.
Flavoxate The therapeutic efficacy of Castor oil can be decreased when used in combination with Flavoxate.
Desipramine The therapeutic efficacy of Castor oil can be decreased when used in combination with Desipramine.
Orphenadrine The therapeutic efficacy of Castor oil can be decreased when used in combination with Orphenadrine.
Escitalopram The therapeutic efficacy of Castor oil can be decreased when used in combination with Escitalopram.
Quetiapine The therapeutic efficacy of Castor oil can be decreased when used in combination with Quetiapine.
Mivacurium The therapeutic efficacy of Castor oil can be decreased when used in combination with Mivacurium.
Diphenidol The therapeutic efficacy of Castor oil can be decreased when used in combination with Diphenidol.
Aripiprazole The therapeutic efficacy of Castor oil can be decreased when used in combination with Aripiprazole.
Chlorprothixene The therapeutic efficacy of Castor oil can be decreased when used in combination with Chlorprothixene.
Metocurine The therapeutic efficacy of Castor oil can be decreased when used in combination with Metocurine.
Pancuronium The therapeutic efficacy of Castor oil can be decreased when used in combination with Pancuronium.
Pipecuronium The therapeutic efficacy of Castor oil can be decreased when used in combination with Pipecuronium.
Methotrimeprazine The therapeutic efficacy of Castor oil can be decreased when used in combination with Methotrimeprazine.
Tiotropium The therapeutic efficacy of Castor oil can be decreased when used in combination with Tiotropium.
Solifenacin The therapeutic efficacy of Castor oil can be decreased when used in combination with Solifenacin.
Isopropamide The therapeutic efficacy of Castor oil can be decreased when used in combination with Isopropamide.
Rapacuronium The therapeutic efficacy of Castor oil can be decreased when used in combination with Rapacuronium.
Mepenzolate The therapeutic efficacy of Castor oil can be decreased when used in combination with Mepenzolate.
Pizotifen The therapeutic efficacy of Castor oil can be decreased when used in combination with Pizotifen.
Fesoterodine The therapeutic efficacy of Castor oil can be decreased when used in combination with Fesoterodine.
Hexocyclium The therapeutic efficacy of Castor oil can be decreased when used in combination with Hexocyclium.
Dimetindene The therapeutic efficacy of Castor oil can be decreased when used in combination with Dimetindene.
Aclidinium The therapeutic efficacy of Castor oil can be decreased when used in combination with Aclidinium.
Dexetimide The therapeutic efficacy of Castor oil can be decreased when used in combination with Dexetimide.
Benactyzine The therapeutic efficacy of Castor oil can be decreased when used in combination with Benactyzine.
Umeclidinium The therapeutic efficacy of Castor oil can be decreased when used in combination with Umeclidinium.
Trimebutine The therapeutic efficacy of Castor oil can be decreased when used in combination with Trimebutine.
Dosulepin The therapeutic efficacy of Castor oil can be decreased when used in combination with Dosulepin.
Imidafenacin The therapeutic efficacy of Castor oil can be decreased when used in combination with Imidafenacin.
Butylscopolamine The therapeutic efficacy of Castor oil can be decreased when used in combination with Butylscopolamine.
Thonzylamine The therapeutic efficacy of Castor oil can be decreased when used in combination with Thonzylamine.
Methscopolamine The therapeutic efficacy of Castor oil can be decreased when used in combination with Methscopolamine.
Revefenacin The therapeutic efficacy of Castor oil can be decreased when used in combination with Revefenacin.
Oxitropium The therapeutic efficacy of Castor oil can be decreased when used in combination with Oxitropium.
Propiverine The therapeutic efficacy of Castor oil can be decreased when used in combination with Propiverine.
Batefenterol The therapeutic efficacy of Castor oil can be decreased when used in combination with Batefenterol.
Mebeverine The therapeutic efficacy of Castor oil can be decreased when used in combination with Mebeverine.
Tropatepine The therapeutic efficacy of Castor oil can be decreased when used in combination with Tropatepine.
Prifinium The therapeutic efficacy of Castor oil can be decreased when used in combination with Prifinium.
Piperidolate The therapeutic efficacy of Castor oil can be decreased when used in combination with Piperidolate.
Benzilone The therapeutic efficacy of Castor oil can be decreased when used in combination with Benzilone.
Difemerine The therapeutic efficacy of Castor oil can be decreased when used in combination with Difemerine.

Target Protein

Prostaglandin E2 receptor EP3 subtype PTGER3
Prostaglandin E2 receptor EP4 subtype PTGER4

Referensi & Sumber

Artikel (PubMed)
  • PMID: 27656091
    Patel VR, Dumancas GG, Kasi Viswanath LC, Maples R, Subong BJ: Castor Oil: Properties, Uses, and Optimization of Processing Parameters in Commercial Production. Lipid Insights. 2016 Sep 7;9:1-12. doi: 10.4137/LPI.S40233. eCollection 2016.
  • PMID: 22615395
    Tunaru S, Althoff TF, Nusing RM, Diener M, Offermanns S: Castor oil induces laxation and uterus contraction via ricinoleic acid activating prostaglandin EP3 receptors. Proc Natl Acad Sci U S A. 2012 Jun 5;109(23):9179-84. doi: 10.1073/pnas.1201627109. Epub 2012 May 21.
  • PMID: 15919203
    Ogunniyi DS: Castor oil: a vital industrial raw material. Bioresour Technol. 2006 Jun;97(9):1086-91. doi: 10.1016/j.biortech.2005.03.028.
  • PMID: 10631825
    Garry D, Figueroa R, Guillaume J, Cucco V: Use of castor oil in pregnancies at term. Altern Ther Health Med. 2000 Jan;6(1):77-9.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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