Peringatan Keamanan

The occurrence of overdose with magnesium citrate is very unlikely but some of the signs of the presence of overdose are diarrhea or severe stomach pain.L2841

Magnesium citrate

DB11110

small molecule approved

Deskripsi

Magnesium citrate is a low volume and osmotic cathartic agent. The cathartic action works primarily through the high osmolarity of the solution which draws large amounts of fluid into space where is used.T215 Magnesium citrate is considered by the FDA as an approved inactive ingredient for approved drug products under the specifications of oral administration of a maximum concentration of 237 mg.L2831 It is also considered as an active ingredient in over-the-counter products.L1113

Struktur Molekul 2D

Berat 451.113
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) The study of the half-life of magnesium citrate is very difficult due to the half-life of the available isotopes for magnesium.[A19349]
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Mean plasma concentration of magnesium after administration of oral doses of magnesium citrate are reported to be of around 0.7 mmol/L and the concentration in saliva rested in 0.28 mmol/L. In reports, it has also been proven that the absorption and bioavailability of magnesium are greater when administered in the form of magnesium citrate when compared with other forms such as magnesium ocude.A33128

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

After oral administration of magnesium citrate, there is a 40% increase in urine excretion of magnesium.A33129 Magnesium citrate is also widely eliminated via the feces because, when present in the bowel, it relaxes the bowel and pulls water into the intestine which increases bowel movement and a significant portion of this agent gets excreted by this via.F99

Interaksi Makanan

1 Data
  • 1. Take with or without food. Taking magnesium supplements with food may reduce the risk of diarrhea.

Interaksi Obat

552 Data
Succinylcholine The therapeutic efficacy of Succinylcholine can be increased when used in combination with Magnesium citrate.
Metocurine iodide The therapeutic efficacy of Metocurine iodide can be increased when used in combination with Magnesium citrate.
Gallamine triethiodide The therapeutic efficacy of Gallamine triethiodide can be increased when used in combination with Magnesium citrate.
Cisatracurium Magnesium citrate may increase the neuromuscular blocking activities of Cisatracurium.
Rocuronium The therapeutic efficacy of Rocuronium can be increased when used in combination with Magnesium citrate.
Atracurium besylate The therapeutic efficacy of Atracurium besylate can be increased when used in combination with Magnesium citrate.
Doxacurium The therapeutic efficacy of Doxacurium can be increased when used in combination with Magnesium citrate.
Mivacurium The therapeutic efficacy of Mivacurium can be increased when used in combination with Magnesium citrate.
Decamethonium The therapeutic efficacy of Decamethonium can be increased when used in combination with Magnesium citrate.
Metocurine The therapeutic efficacy of Metocurine can be increased when used in combination with Magnesium citrate.
Pancuronium The therapeutic efficacy of Pancuronium can be increased when used in combination with Magnesium citrate.
Pipecuronium The therapeutic efficacy of Pipecuronium can be increased when used in combination with Magnesium citrate.
Vecuronium The therapeutic efficacy of Vecuronium can be increased when used in combination with Magnesium citrate.
Rapacuronium The therapeutic efficacy of Rapacuronium can be increased when used in combination with Magnesium citrate.
Pyrantel The therapeutic efficacy of Pyrantel can be increased when used in combination with Magnesium citrate.
Neosaxitoxin The therapeutic efficacy of Neosaxitoxin can be increased when used in combination with Magnesium citrate.
Atracurium The therapeutic efficacy of Atracurium can be increased when used in combination with Magnesium citrate.
Gallamine The therapeutic efficacy of Gallamine can be increased when used in combination with Magnesium citrate.
Alcuronium The therapeutic efficacy of Alcuronium can be increased when used in combination with Magnesium citrate.
Tubocurarine The therapeutic efficacy of Tubocurarine can be increased when used in combination with Magnesium citrate.
Calcitriol The serum concentration of Magnesium citrate can be increased when it is combined with Calcitriol.
Calcifediol The serum concentration of Magnesium citrate can be increased when it is combined with Calcifediol.
Paricalcitol The serum concentration of Magnesium citrate can be increased when it is combined with Paricalcitol.
Dihydrotachysterol The serum concentration of Magnesium citrate can be increased when it is combined with Dihydrotachysterol.
Alfacalcidol The serum concentration of Magnesium citrate can be increased when it is combined with Alfacalcidol.
Seocalcitol The serum concentration of Magnesium citrate can be increased when it is combined with Seocalcitol.
Inecalcitol The serum concentration of Magnesium citrate can be increased when it is combined with Inecalcitol.
Becocalcidiol The serum concentration of Magnesium citrate can be increased when it is combined with Becocalcidiol.
Eldecalcitol The serum concentration of Magnesium citrate can be increased when it is combined with Eldecalcitol.
1alpha,24S-Dihydroxyvitamin D2 The serum concentration of Magnesium citrate can be increased when it is combined with 1alpha,24S-Dihydroxyvitamin D2.
Elocalcitol The serum concentration of Magnesium citrate can be increased when it is combined with Elocalcitol.
Maxacalcitol The serum concentration of Magnesium citrate can be increased when it is combined with Maxacalcitol.
Doxercalciferol The serum concentration of Magnesium citrate can be increased when it is combined with Doxercalciferol.
1alpha-Hydroxyvitamin D5 The serum concentration of Magnesium citrate can be increased when it is combined with 1alpha-Hydroxyvitamin D5.
Previtamin D(3) The serum concentration of Magnesium citrate can be increased when it is combined with Previtamin D(3).
Deferiprone Magnesium citrate can cause a decrease in the absorption of Deferiprone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Eltrombopag Magnesium citrate can cause a decrease in the absorption of Eltrombopag resulting in a reduced serum concentration and potentially a decrease in efficacy.
Raltegravir Magnesium citrate can cause a decrease in the absorption of Raltegravir resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deferasirox Magnesium citrate can cause a decrease in the absorption of Deferasirox resulting in a reduced serum concentration and potentially a decrease in efficacy.
Halofantrine Magnesium citrate can cause a decrease in the absorption of Halofantrine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Misoprostol The risk or severity of adverse effects can be increased when Magnesium citrate is combined with Misoprostol.
Tramadol The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Tramadol.
Trospium The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Trospium.
Oxyphenonium The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Oxyphenonium.
Benzatropine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Benzatropine.
Ziprasidone The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Ziprasidone.
Disopyramide The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Disopyramide.
Amitriptyline The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Amitriptyline.
Ipratropium The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Ipratropium.
Olanzapine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Olanzapine.
Metixene The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Metixene.
Terfenadine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Terfenadine.
Buclizine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Buclizine.
Clozapine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Clozapine.
Doxylamine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Doxylamine.
Trihexyphenidyl The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Trihexyphenidyl.
Oxyphencyclimine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Oxyphencyclimine.
Procyclidine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Procyclidine.
Profenamine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Profenamine.
Promazine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Promazine.
Hyoscyamine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Hyoscyamine.
Cyproheptadine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Cyproheptadine.
Imipramine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Imipramine.
Methscopolamine bromide The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Methscopolamine bromide.
Chlorpromazine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Chlorpromazine.
Darifenacin The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Darifenacin.
Tridihexethyl The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Tridihexethyl.
Triflupromazine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Triflupromazine.
Anisotropine methylbromide The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Anisotropine methylbromide.
Nortriptyline The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Nortriptyline.
Amoxapine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Amoxapine.
Atropine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Atropine.
Pirenzepine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Pirenzepine.
Paroxetine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Paroxetine.
Homatropine methylbromide The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Homatropine methylbromide.
Scopolamine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Scopolamine.
Benzquinamide The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Benzquinamide.
Clidinium The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Clidinium.
Propiomazine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Propiomazine.
Propantheline The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Propantheline.
Dicyclomine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Dicyclomine.
Biperiden The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Biperiden.
Brompheniramine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Brompheniramine.
Flupentixol The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Flupentixol.
Cocaine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Cocaine.
Quinidine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Quinidine.
Maprotiline The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Maprotiline.
Methantheline The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Methantheline.
Cycrimine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Cycrimine.
Glycopyrronium The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Glycopyrronium.
Tolterodine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Tolterodine.
Oxybutynin The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Oxybutynin.
Promethazine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Promethazine.
Diphenhydramine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Diphenhydramine.
Doxepin The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Doxepin.
Flavoxate The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Flavoxate.
Desipramine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Desipramine.
Orphenadrine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Orphenadrine.
Escitalopram The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Escitalopram.
Quetiapine The therapeutic efficacy of Magnesium citrate can be decreased when used in combination with Quetiapine.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 14596323
    Walker AF, Marakis G, Christie S, Byng M: Mg citrate found more bioavailable than other Mg preparations in a randomised, double-blind study. Magnes Res. 2003 Sep;16(3):183-91.
  • PMID: 11569488
    Rylander R, Megevand Y, Lasserre B, Amstutz W, Granbom S: Moderate alcohol consumption and urinary excretion of magnesium and calcium. Scand J Clin Lab Invest. 2001;61(5):401-5.
  • PMID: 5383308
    Nielsen SP: Free and protein-bound magnesium in normal human plasma determined by ultracentrifugation and ultrafiltration. Scand J Clin Lab Invest. 1969 May;23(3):219-25.
  • PMID: 26069819
    Jahnen-Dechent W, Ketteler M: Magnesium basics. Clin Kidney J. 2012 Feb;5(Suppl 1):i3-i14. doi: 10.1093/ndtplus/sfr163.
Textbook
  • Kim D. and Pickhardt P. (2010). CT Colonography. Elsevier.
Attachment

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