N-acetyltyrosine

DB11102

small molecule approved

Deskripsi

N-acetyltyrosine, also referred to as N-acetyl-L-tyrosine, is used in place of as a tyrosine precursor. DB00135 is a non-essential amino acid with a polar side group. N-acetyltyrosine is administered as parenteral nutrition or intravenous infusion due to its enhanced solubility compared to tyrosine A32652. It is typically administered as a source of nutritional support where oral nutrition is inadequate or cannot be tolerated.

Struktur Molekul 2D

Berat 223.2252
Wujud solid

Peta Jejaring Molekuler
Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

Data absorpsi tidak tersedia.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

N-acetyltyrosine is eliminated in the urine A27136. The extent of urinary elimination versus utilization in the tissues appears to be related to the rapidity of infusion. When infused slowly in standard doses as in the clinical setting, about 35% is excreted unchanged in the urine. When larger doses are infused rapidly, much higher amounts are excreted reaching values up to 56% A32654. In rat studies it was found that of the drug eliminated in the urine about 74% is present as unchanged N-acetyltyrosine and 23% is present as tyrosine A32652.

Interaksi Obat

723 Data
Cyclosporine Cyclosporine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.
Aceclofenac Aceclofenac may decrease the excretion rate of N-acetyltyrosine which could result in a higher serum level.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 14621123
    Hoffer LJ, Sher K, Saboohi F, Bernier P, MacNamara EM, Rinzler D: N-acetyl-L-tyrosine as a tyrosine source in adult parenteral nutrition. JPEN J Parenter Enteral Nutr. 2003 Nov-Dec;27(6):419-22.
  • PMID: 3925425
    Im HA, Meyer PD, Stegink LD: N-acetyl-L-tyrosine as a tyrosine source during total parenteral nutrition in adult rats. Pediatr Res. 1985 Jun;19(6):514-8.
  • PMID: 2507878
    Magnusson I, Ekman L, Wangdahl M, Wahren J: N-acetyl-L-tyrosine and N-acetyl-L-cysteine as tyrosine and cysteine precursors during intravenous infusion in humans. Metabolism. 1989 Oct;38(10):957-61.

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