Peringatan Keamanan

Patients taking more than 4g of calcium a day are at risk of hypercalcemia and metabolic alkalosis L811. Chronic intake of calcium supplements is associated with adverse gastrointestinal symptoms such as constipation and flatulence L811 A19538.

Calcium citrate

DB11093

small molecule approved investigational

Deskripsi

Calcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.

Struktur Molekul 2D

Berat 498.432
Wujud solid

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) -
Volume Distribusi -
Klirens (Clearance) -

Absorpsi

The percentage of calcium absorbed varies inversely with intake A19538. Tmax of about 3.5-5h varying with formulation A19541.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions T36.

Interaksi Makanan

1 Data
  • 1. Take with or without food.

Interaksi Obat

163 Data
Grepafloxacin Calcium citrate can cause a decrease in the absorption of Grepafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enoxacin Calcium citrate can cause a decrease in the absorption of Enoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pefloxacin Calcium citrate can cause a decrease in the absorption of Pefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ciprofloxacin Calcium citrate can cause a decrease in the absorption of Ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Trovafloxacin Calcium citrate can cause a decrease in the absorption of Trovafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalidixic acid Calcium citrate can cause a decrease in the absorption of Nalidixic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rosoxacin Calcium citrate can cause a decrease in the absorption of Rosoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cinoxacin Calcium citrate can cause a decrease in the absorption of Cinoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lomefloxacin Calcium citrate can cause a decrease in the absorption of Lomefloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gatifloxacin Calcium citrate can cause a decrease in the absorption of Gatifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Norfloxacin Calcium citrate can cause a decrease in the absorption of Norfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Gemifloxacin Calcium citrate can cause a decrease in the absorption of Gemifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ofloxacin Calcium citrate can cause a decrease in the absorption of Ofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sparfloxacin Calcium citrate can cause a decrease in the absorption of Sparfloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Temafloxacin Calcium citrate can cause a decrease in the absorption of Temafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fleroxacin Calcium citrate can cause a decrease in the absorption of Fleroxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m ciprofloxacin Calcium citrate can cause a decrease in the absorption of Technetium Tc-99m ciprofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Garenoxacin Calcium citrate can cause a decrease in the absorption of Garenoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nemonoxacin Calcium citrate can cause a decrease in the absorption of Nemonoxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Flumequine Calcium citrate can cause a decrease in the absorption of Flumequine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Enrofloxacin Calcium citrate can cause a decrease in the absorption of Enrofloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Orbifloxacin Calcium citrate can cause a decrease in the absorption of Orbifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sarafloxacin Calcium citrate can cause a decrease in the absorption of Sarafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Difloxacin Calcium citrate can cause a decrease in the absorption of Difloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pazufloxacin Calcium citrate can cause a decrease in the absorption of Pazufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Prulifloxacin Calcium citrate can cause a decrease in the absorption of Prulifloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Delafloxacin Calcium citrate can cause a decrease in the absorption of Delafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sitafloxacin Calcium citrate can cause a decrease in the absorption of Sitafloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Oxolinic acid Calcium citrate can cause a decrease in the absorption of Oxolinic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Rufloxacin Calcium citrate can cause a decrease in the absorption of Rufloxacin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Pipemidic acid Calcium citrate can cause a decrease in the absorption of Pipemidic acid resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deferiprone The serum concentration of Deferiprone can be decreased when it is combined with Calcium citrate.
Dobutamine The therapeutic efficacy of Dobutamine can be decreased when used in combination with Calcium citrate.
Dolutegravir The serum concentration of Dolutegravir can be decreased when it is combined with Calcium citrate.
Eltrombopag The serum concentration of Eltrombopag can be decreased when it is combined with Calcium citrate.
Estramustine Calcium citrate can cause a decrease in the absorption of Estramustine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcium acetate The risk or severity of adverse effects can be increased when Calcium citrate is combined with Calcium acetate.
Acetyldigitoxin Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Acetyldigitoxin.
Deslanoside Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Deslanoside.
Ouabain Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Ouabain.
Digitoxin Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Digitoxin.
Oleandrin Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Oleandrin.
Cymarin Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Cymarin.
Proscillaridin Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Proscillaridin.
Lanatoside C Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Lanatoside C.
Gitoformate Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Gitoformate.
Peruvoside Calcium citrate may increase the arrhythmogenic and cardiotoxic activities of Peruvoside.
Strontium ranelate The serum concentration of Strontium ranelate can be decreased when it is combined with Calcium citrate.
Doxycycline The serum concentration of Doxycycline can be decreased when it is combined with Calcium citrate.
Lymecycline The serum concentration of Lymecycline can be decreased when it is combined with Calcium citrate.
Clomocycline The serum concentration of Clomocycline can be decreased when it is combined with Calcium citrate.
Oxytetracycline The serum concentration of Oxytetracycline can be decreased when it is combined with Calcium citrate.
Demeclocycline The serum concentration of Demeclocycline can be decreased when it is combined with Calcium citrate.
Tetracycline The serum concentration of Tetracycline can be decreased when it is combined with Calcium citrate.
Metacycline The serum concentration of Metacycline can be decreased when it is combined with Calcium citrate.
Minocycline The serum concentration of Minocycline can be decreased when it is combined with Calcium citrate.
Sarecycline The serum concentration of Sarecycline can be decreased when it is combined with Calcium citrate.
Omadacycline The serum concentration of Omadacycline can be decreased when it is combined with Calcium citrate.
Penimepicycline The serum concentration of Penimepicycline can be decreased when it is combined with Calcium citrate.
Methyclothiazide Methyclothiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Chlorthalidone Chlorthalidone may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Bendroflumethiazide Bendroflumethiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Metolazone Metolazone may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Benzthiazide Benzthiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Hydroflumethiazide Hydroflumethiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Indapamide Indapamide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Chlorothiazide Chlorothiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Trichlormethiazide Trichlormethiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Polythiazide Polythiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Quinethazone Quinethazone may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Cyclopenthiazide Cyclopenthiazide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Epitizide Epitizide may decrease the excretion rate of Calcium citrate which could result in a higher serum level.
Triethylenetetramine Calcium citrate can cause a decrease in the absorption of Triethylenetetramine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Calcitriol The risk or severity of adverse effects can be increased when Calcitriol is combined with Calcium citrate.
Calcifediol The risk or severity of adverse effects can be increased when Calcifediol is combined with Calcium citrate.
Paricalcitol The risk or severity of adverse effects can be increased when Paricalcitol is combined with Calcium citrate.
Dihydrotachysterol The risk or severity of adverse effects can be increased when Dihydrotachysterol is combined with Calcium citrate.
Alfacalcidol The risk or severity of adverse effects can be increased when Alfacalcidol is combined with Calcium citrate.
Calcipotriol The risk or severity of adverse effects can be increased when Calcipotriol is combined with Calcium citrate.
Seocalcitol The risk or severity of adverse effects can be increased when Seocalcitol is combined with Calcium citrate.
Inecalcitol The risk or severity of adverse effects can be increased when Inecalcitol is combined with Calcium citrate.
Becocalcidiol The risk or severity of adverse effects can be increased when Becocalcidiol is combined with Calcium citrate.
Eldecalcitol The risk or severity of adverse effects can be increased when Eldecalcitol is combined with Calcium citrate.
1alpha,24S-Dihydroxyvitamin D2 The risk or severity of adverse effects can be increased when 1alpha,24S-Dihydroxyvitamin D2 is combined with Calcium citrate.
Elocalcitol The risk or severity of adverse effects can be increased when Elocalcitol is combined with Calcium citrate.
Maxacalcitol The risk or severity of adverse effects can be increased when Maxacalcitol is combined with Calcium citrate.
Doxercalciferol The risk or severity of adverse effects can be increased when Doxercalciferol is combined with Calcium citrate.
1alpha-Hydroxyvitamin D5 The risk or severity of adverse effects can be increased when 1alpha-Hydroxyvitamin D5 is combined with Calcium citrate.
Tacalcitol The risk or severity of adverse effects can be increased when Tacalcitol is combined with Calcium citrate.
Previtamin D(3) The risk or severity of adverse effects can be increased when Previtamin D(3) is combined with Calcium citrate.
Thyrotropin alfa The therapeutic efficacy of Thyrotropin alfa can be decreased when used in combination with Calcium citrate.
Liothyronine The therapeutic efficacy of Liothyronine can be decreased when used in combination with Calcium citrate.
Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Calcium citrate.
Liotrix The therapeutic efficacy of Liotrix can be decreased when used in combination with Calcium citrate.
Tiratricol The therapeutic efficacy of Tiratricol can be decreased when used in combination with Calcium citrate.
Thyroid, porcine The therapeutic efficacy of Thyroid, porcine can be decreased when used in combination with Calcium citrate.
Pamidronic acid The serum concentration of Pamidronic acid can be decreased when it is combined with Calcium citrate.
Zoledronic acid The serum concentration of Zoledronic acid can be decreased when it is combined with Calcium citrate.
Alendronic acid The serum concentration of Alendronic acid can be decreased when it is combined with Calcium citrate.

Target Protein

Extracellular calcium-sensing receptor CASR
Calreticulin CALR
Calcium and integrin-binding protein 1 CIB1
Programmed cell death protein 6 PDCD6
Sorcin SRI
Calcineurin B homologous protein 1 CHP1
SPARC SPARC
Calnexin CANX
Fibrillin-2 FBN2
Protein S100-B S100B
Calsequestrin-2 CASQ2
Regucalcin RGN
Peflin PEF1
Protein S100-A6 S100A6
Translationally-controlled tumor protein TPT1
Calcium and integrin-binding family member 2 CIB2
Protein S100-A13 S100A13
Calsequestrin-1 CASQ1
Nucleobindin-1 NUCB1
Nucleobindin-2 NUCB2
Fibrillin-3 FBN3
Grancalcin GCA
Calcium-dependent secretion activator 1 CADPS
Calmodulin-2 CALM2
Calmodulin-3 CALM3
Protein S100-A16 S100A16
Calretinin CALB2
Calcyphosin CAPS
Calcium-dependent secretion activator 2 CADPS2
Calreticulin-3 CALR3
Neurexin-1 NRXN1
Neuronal calcium sensor 1 NCS1
Calmodulin CALM1

Referensi & Sumber

Artikel (PubMed)
  • PMID: 26174589
    Reid IR, Bristow SM, Bolland MJ: Calcium supplements: benefits and risks. J Intern Med. 2015 Oct;278(4):354-68. doi: 10.1111/joim.12394. Epub 2015 Jul 14.
  • PMID: 10579145
    Heller HJ, Stewart A, Haynes S, Pak CY: Pharmacokinetics of calcium absorption from two commercial calcium supplements. J Clin Pharmacol. 1999 Nov;39(11):1151-4.
Textbook
  • ISBN: 978-0-07-17803-2
    21. (2012). In Ganong's Review of Medical Physiology (24th ed., pp. 377-385). McGraw Hill.

Contoh Produk & Brand

Produk: 88 • International brands: 0
Produk
  • AzesChew
    Bar, chewable • - • Oral • US
  • Bakanasan Calcium Citrate Powder
    Powder • 63.4 mg / g • Oral • Canada • OTC • Approved
  • BasoSAN
    Powder • - • Oral • US
  • BasoSAN
    Capsule • - • Oral • US
  • BasoSAN
    Capsule • - • Oral • US
  • Bodysmarts With Calcium
    Tablet • 30 mg • Oral • Canada • OTC • Approved
  • Cal-citrus
    Tablet • 200 mg • Oral • Canada • OTC • Approved
  • Cal-mag (one To One) With Potass & Zinc
    Tablet • - • Oral • Canada • OTC • Approved
Menampilkan 8 dari 88 produk.

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