Peringatan Keamanan

The oral LD50 value in rats is 360mg/kg and the dermal LD50 value is >2000mg/kg. Repeated or prolonged dermal contact can cause irritant symptoms such as reddening of the skin, blisters, or dermatitis.

Stannous fluoride

DB11092

small molecule approved

Deskripsi

Stannous Fluoride, or Tn(II) Fluoride, is a compound commonly used in toothpastes for the prevention of gingivitis, dental infections, cavities, and to relieve dental hypersensitivity. Although similar in function and activity to Sodium Fluoride (NaF), the conventionally added ingredient in toothpastes, stannous fluoride has been shown to be more effective at stopping and reversing dental lesions ^A19581. It manages and prevents dental caries and gingivitis by promoting enamel mineralization ^A19580, reducing gingival inflammation and bleeding A19582, A19583 through its potential broad-spectrum antibiotic effect and modulation of the microbial composition of the dental biofilm ^A19581. It is an FDA-approved over-the-counter product.

Struktur Molekul 2D

Berat 156.71

Wujud solid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) The half-life for the decay of the salivary elimination rate constant was 13 min [A19597].

Volume Distribusi Stannous fluoride is cleared from saliva rapidly but very well retained in gingival plaque for a prolonged period of time [A19597].

Klirens (Clearance) Stimulated and nonstimulated salivary elimination microrate constants in this case would be ?1 and 0.5 min^?1, respectively [A19597].

Absorpsi

Tin is retained in the demineralized organic matrix to some extent, diffuses through the phosphorylated non-collagenous proteins in the dentine called phosphophoryn and accumulates in the underlying mineralized tissue.

Metabolisme

Data metabolisme tidak tersedia.

Rute Eliminasi

Materials introduced into the oral cavity can be eliminated by salivary washout and swallowing, absorption through oral surfaces, or degradation ^A19597.

Interaksi Obat

0 Data

Tidak ada data.

Referensi & Sumber

Artikel (PubMed)

PMID: 26030135
Algarni AA, Mussi MC, Moffa EB, Lippert F, Zero DT, Siqueira WL, Hara AT: The impact of stannous, fluoride ions and its combination on enamel pellicle proteome and dental erosion prevention. PLoS One. 2015 Jun 1;10(6):e0128196. doi: 10.1371/journal.pone.0128196. eCollection 2015.
PMID: 27838508
Cheng X, Liu J, Li J, Zhou X, Wang L, Liu J, Xu X: Comparative effect of a stannous fluoride toothpaste and a sodium fluoride toothpaste on a multispecies biofilm. Arch Oral Biol. 2017 Feb;74:5-11. doi: 10.1016/j.archoralbio.2016.10.030. Epub 2016 Oct 29.
PMID: 17645550
Mallatt M, Mankodi S, Bauroth K, Bsoul SA, Bartizek RD, He T: A controlled 6-month clinical trial to study the effects of a stannous fluoride dentifrice on gingivitis. J Clin Periodontol. 2007 Sep;34(9):762-7. Epub 2007 Jul 23.
PMID: 24693625
He T, Barker ML, Biesbrock A, Miner M, Amini P, Goyal CR, Qaqish J: Evaluation of anti-gingivitis benefits of stannous fluoride dentifrice among triclosan dentifrice users. Am J Dent. 2013 Aug;26(4):175-9.
PMID: 13579125
NEVITT GA, WITTER DH, BOWMAN WD: Topical applications of sodium fluoride and stannous fluoride. Public Health Rep. 1958 Sep;73(9):847-50.
PMID: 20662911
Ganss C, Hardt M, Lussi A, Cocks AK, Klimek J, Schlueter N: Mechanism of action of tin-containing fluoride solutions as anti-erosive agents in dentine - an in vitro tin-uptake, tissue loss, and scanning electron microscopy study. Eur J Oral Sci. 2010 Aug;118(4):376-84. doi: 10.1111/j.1600-0722.2010.00742.x.
PMID: 19189400
Scott DC, Coggan JW, Cruze CA, He T, Johnson RD: Topical oral cavity pharmacokinetic modeling of a stannous fluoride dentifrice: an unusual two compartment model. J Pharm Sci. 2009 Oct;98(10):3862-70. doi: 10.1002/jps.21691.

Contoh Produk & Brand

Produk: 317 • International brands: 0

Produk

0.4% Stannous Fluoride Brush On Gel

Gel • 0.4 % • Dental • Canada • OTC • Approved
0.63% Stannous Fluor. Oral Rinse Concentrate

Liquid • 0.63 % • Dental • Canada • OTC • Approved
1.64% Stan. Fluor. Office Rinse Concentrate

Liquid • 1.64 % • Dental • Canada • OTC • Approved
3.28% Stannous Fluor. Irrigation Concentrate

Liquid • 3.28 % • Dental • Canada • OTC • Approved
Burkhart

Concentrate • 0.3408 g/284g • Dental • US
Burkhart

Gel • 0.116 g/120g • Dental • US • OTC
Burkhart

Gel • 0.116 g/120g • Dental • US • OTC
Burkhart

Concentrate • 0.3408 g/284g • Dental • US

Menampilkan 8 dari 317 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.