Peringatan Keamanan

Oral LD50 in mouse is 2000 mg/kg, and dermal LD50 is 4060 mg/kg in rat and 2000 mg/kg pig. LC50 of hydrogen peroxide vapours in rat is 2000 mg/m at 4 hours MSDS.

Oral ingestion of high dose hydrogen peroxide may cause chest and stomach pain, loss of consciousness, motor disorders, microhemorrhages and moderate leucocytosis in humans. Inhalation of highly concentrated vapours causes extreme irritation of nose and throat ^L2024.

Hydrogen peroxide has no known carcinogenic potential. It was shown to be mutagenic to bacteria (Salmonella typhimurium) and the fungi, Neurospora crassa and Aspergillis chevallieri, and induced DNA damage in Escheria coli ^L2024. It also caused sister chromatid exchanges and chromosomal aberrations in mammalian cells in vitro ^L2024.

Hydrogen peroxide

DB11091

small molecule approved vet_approved

Deskripsi

Hydrogen peroxide is the simplest peroxide with a chemical formula H2O2. Hydrogen peroxide is an unstable compound in the presence of a base or catalyst, and is typically stored with a stabilizer in a weakly acidic solution. If heated to its boiling point, it may undergo potentially explosive thermal decomposition. Hydrogen peroxide is formed in the body of mammals during reduction of oxygen either directly in a two-electron transfer reaction ^L2024. As a natural product of metabolism, it readily undergoes decomposition by catalase in normal cells ^L2024.

Due to its potent and broad-spectrum antimicrobial actions, hydrogen peroxide is used in both liquid and gas form for preservative, disinfection and sterilization applications as an oxidative biocide ^A32369. It is used in industrial and cosmetic applications as a bleaching agent. Hydrogen peroxide is also considered as a generally recognized as safe compound by the FDA ^L2024; it is used as an antimicrobial agent in starch and cheese products, and as an oxidizing and reducing agent in products containing dried eggs, dried egg whites, and dried egg yolks.

Struktur Molekul 2D

Berat 34.0147

Wujud liquid

Peta Jejaring Molekuler

Obat Target Gen Interaksi Enzim Transporter Carrier

Legenda: Obat • Target • Gen • Enzim • (Panah → menunjukkan arah efek / relasi) • Transporter • Carrier

1. Pendahuluan & Konsep

Fitur visualisasi ini dikembangkan menggunakan pendekatan Graph Theory untuk memetakan hubungan polifarmasi dan molekuler. Entitas (Obat, Target, Gen) direpresentasikan sebagai Simpul (Nodes), sedangkan hubungan biologisnya sebagai Sisi (Edges).

2. Sumber Data (Validasi)

Data Obat: Diekstraksi dari elemen drugbank-id dan name pada skema XML DrugBank.
Target Protein: Diambil dari elemen targets/target yang memuat polipeptida sasaran.
Genetik: Disinkronisasi dari sub-elemen gene-name dan varian snp-effects.
Genetik: Jumlah titik node dibatasi pada maksimal 10 (Slice=10) interaksi untuk menghindari tumpukan data.

3. Algoritma Visualisasi

Tata letak grafik menggunakan algoritma Force-Directed Graph (Barnes-Hut). Model fisika ini menerapkan gaya tolak-menolak antar simpul (Gravitasi: -3000) agar tidak tumpang tindih, serta gaya pegas (Spring: 0.04) pada garis penghubung untuk fleksibilitas interaksi.

4. Legenda Visual

Obat Utama (Pusat Analisis)

Target Protein (Mekanisme)

Gen (Faktor Genetik)

Metode ini mendukung analisis Precision Medicine dan evaluasi risiko Drug-Drug Interaction (DDI).

Profil Farmakokinetik

Waktu Paruh (Half-Life) -

Volume Distribusi Target organs affected by hydrogen peroxide include the lungs, intestine, thymus, liver, and kidney [L2024].

Klirens (Clearance) -

Absorpsi

It is reported that hydrogen peroxide is decomposed before absorption in the intestine. Solutions of hydrogen peroxide displays poor penetration when applied to tissue ^L2024.

Metabolisme

Hydrogen peroxide is reduced by glutathione peroxidase, which is an endogenous enzyme in human tissue. It is rapidly decomposed to oxygen and water when in contact with catalase, an enzyme found in blood and most tissues ^L2024.

Rute Eliminasi

Data eliminasi belum tersedia.

Interaksi Obat

57 Data

Alpha-1-proteinase inhibitor	Alpha-1-proteinase inhibitor may increase the thrombogenic activities of Hydrogen peroxide.
Menadione	Menadione may increase the thrombogenic activities of Hydrogen peroxide.
Tranexamic acid	Tranexamic acid may increase the thrombogenic activities of Hydrogen peroxide.
Aminocaproic acid	Aminocaproic acid may increase the thrombogenic activities of Hydrogen peroxide.
Aprotinin	Aprotinin may increase the thrombogenic activities of Hydrogen peroxide.
Aminomethylbenzoic acid	Hydrogen peroxide may increase the thrombogenic activities of Aminomethylbenzoic acid.
Camostat	Hydrogen peroxide may increase the thrombogenic activities of Camostat.
Menadione bisulfite	Hydrogen peroxide may increase the thrombogenic activities of Menadione bisulfite.
Fibrinogen human	The therapeutic efficacy of Fibrinogen human can be increased when used in combination with Hydrogen peroxide.
Tretinoin	The risk or severity of Thrombosis can be increased when Hydrogen peroxide is combined with Tretinoin.
Antihemophilic factor, human recombinant	Hydrogen peroxide may increase the thrombogenic activities of Antihemophilic factor, human recombinant.
Coagulation factor VIIa Recombinant Human	Hydrogen peroxide may increase the thrombogenic activities of Coagulation factor VIIa Recombinant Human.
Coagulation Factor IX (Recombinant)	Hydrogen peroxide may increase the thrombogenic activities of Coagulation Factor IX (Recombinant).
Calcium	Hydrogen peroxide may increase the thrombogenic activities of Calcium.
Pantothenic acid	Hydrogen peroxide may increase the thrombogenic activities of Pantothenic acid.
Formic acid	Hydrogen peroxide may increase the thrombogenic activities of Formic acid.
Platelet Activating Factor	Hydrogen peroxide may increase the thrombogenic activities of Platelet Activating Factor.
Turoctocog alfa	Hydrogen peroxide may increase the thrombogenic activities of Turoctocog alfa.
Catridecacog	Hydrogen peroxide may increase the thrombogenic activities of Catridecacog.
Antihemophilic factor (recombinant), PEGylated	Hydrogen peroxide may increase the thrombogenic activities of Antihemophilic factor (recombinant), PEGylated.
Prothrombin	Hydrogen peroxide may increase the thrombogenic activities of Prothrombin.
Factor IX Complex (Human)	Hydrogen peroxide may increase the thrombogenic activities of Factor IX Complex (Human).
Susoctocog alfa	Hydrogen peroxide may increase the thrombogenic activities of Susoctocog alfa.
Eftrenonacog alfa	Hydrogen peroxide may increase the thrombogenic activities of Eftrenonacog alfa.
Rusalatide acetate	Hydrogen peroxide may increase the thrombogenic activities of Rusalatide acetate.
Vatreptacog alfa	Hydrogen peroxide may increase the thrombogenic activities of Vatreptacog alfa.
Factor XIII (human)	Hydrogen peroxide may increase the thrombogenic activities of Factor XIII (human).
Von Willebrand factor human	Hydrogen peroxide may increase the thrombogenic activities of Von Willebrand factor human.
Coagulation factor X human	Hydrogen peroxide may increase the thrombogenic activities of Coagulation factor X human.
Coagulation factor VII human	Hydrogen peroxide may increase the thrombogenic activities of Coagulation factor VII human.
Anti-inhibitor coagulant complex	Hydrogen peroxide may increase the thrombogenic activities of Anti-inhibitor coagulant complex.
Coagulation Factor IX Human	Hydrogen peroxide may increase the thrombogenic activities of Coagulation Factor IX Human.
Antihemophilic factor human	Hydrogen peroxide may increase the thrombogenic activities of Antihemophilic factor human.
Kallidinogenase	Hydrogen peroxide may increase the thrombogenic activities of Kallidinogenase.
Trenonacog alfa	Hydrogen peroxide may increase the thrombogenic activities of Trenonacog alfa.
Albutrepenonacog alfa	Hydrogen peroxide may increase the thrombogenic activities of Albutrepenonacog alfa.
Emicizumab	Hydrogen peroxide may increase the thrombogenic activities of Emicizumab.
Nonacog beta pegol	Hydrogen peroxide may increase the thrombogenic activities of Nonacog beta pegol.
Moroctocog alfa	Hydrogen peroxide may increase the thrombogenic activities of Moroctocog alfa.
Beroctocog alfa	Hydrogen peroxide may increase the thrombogenic activities of Beroctocog alfa.
Andexanet alfa	Hydrogen peroxide may increase the thrombogenic activities of Andexanet alfa.
Calcium cation	Hydrogen peroxide may increase the thrombogenic activities of Calcium cation.
Damoctocog alfa pegol	Hydrogen peroxide may increase the thrombogenic activities of Damoctocog alfa pegol.
Turoctocog alfa pegol	Hydrogen peroxide may increase the thrombogenic activities of Turoctocog alfa pegol.
Acetylcysteine	The therapeutic efficacy of Acetylcysteine can be decreased when used in combination with Hydrogen peroxide.
Alteplase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Alteplase.
Urokinase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Urokinase.
Reteplase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Reteplase.
Anistreplase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Anistreplase.
Tenecteplase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Tenecteplase.
Streptokinase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Streptokinase.
Lanoteplase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Lanoteplase.
Amediplase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Amediplase.
Saruplase	The therapeutic efficacy of Hydrogen peroxide can be decreased when used in combination with Saruplase.
Protein S human	Hydrogen peroxide may increase the thrombogenic activities of Protein S human.
Rurioctocog alfa pegol	Hydrogen peroxide may increase the thrombogenic activities of Rurioctocog alfa pegol.
Etranacogene dezaparvovec	Hydrogen peroxide may increase the thrombogenic activities of Etranacogene dezaparvovec.

Target Protein

Tyrosine-protein phosphatase non-receptor type 1 PTPN1

Referensi & Sumber

Artikel (PubMed)

PMID: 20713407
Finnegan M, Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms. J Antimicrob Chemother. 2010 Oct;65(10):2108-15. doi: 10.1093/jac/dkq308. Epub 2010 Aug 16.
PMID: 22532463
Linley E, Denyer SP, McDonnell G, Simons C, Maillard JY: Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action. J Antimicrob Chemother. 2012 Jul;67(7):1589-96. doi: 10.1093/jac/dks129. Epub 2012 Apr 24.

Link

Contoh Produk & Brand

Produk: 436 • International brands: 0

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Menampilkan 8 dari 436 produk.

Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.