Peringatan Keamanan

No toxicokinetic data available.

Cocoa butter

DB11086

biotech approved

Deskripsi

Cocoa butter is an edible natural fat obtained from the Theobroma cocoa seeds that is predominantly found in dark chocolate A33033. It is a rich source of monounsaturated and saturated fatty acids A33040 that mainly contains approximately 33% DB04224, 25% DB03796, and 33% DB03193 A20409 but does not contain caffeine or theobromine. Fat cocoa solids, including cocoa butter, have lower phenolic content than non-fat cocoa solids but may contain some polyphenols of different structures of flavonoids with antioxidant properties A33041.

Cocoa butter is included in chocolate and other food products, and can also be found in over-the-counter skin products such as lotions, creams, and bars intended to maintain skin softness. While cocoa butter has skin moisturizing properties, it was not shown to reduce the likelihood of developing of striae gravidarum, or stretch marks, in a double-blind, randomized clinical trial of women in the first trimester A33031. Still, it is a common active ingredient for prevention of skin dryness in cosmetic and skincare products. Oftentimes cocoa butter is used in over-the-counter pharmaceutical products and suppositories. The lipid-lowering effects of cocoa butter have been studied and investigated, as fatty acid constituents of cocoa butter are known to exhibit lipid-lowering properties. Dyslipidemia is characterized by elevated levels of plasma triglyceride and very-low-density lipoprotein (VLDL) cholesterol due to overproduction of large triglyceride-enriched VLDL cholesterol particles A20409. Cocoa butter has shown to reduce VLDL cholesterol levels in animal studies, suggesting its potential use in lipid disorders.

Struktur Molekul 2D

Struktur tidak tersedia

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) No pharmacokinetic data available.
Volume Distribusi No pharmacokinetic data available.
Klirens (Clearance) No pharmacokinetic data available.

Absorpsi

Cocoa butter displays poor bioavailability and low absorption compared to other oils A20409.

Metabolisme

No pharmacokinetic data available.

Rute Eliminasi

No pharmacokinetic data available.

Interaksi Obat

0 Data
Tidak ada data.

Referensi & Sumber

Artikel (PubMed)
  • PMID: 25136602
    Yildirim E, Cinar M, Yalcinkaya I, Ekici H, Atmaca N, Guncum E: Effect of cocoa butter and sunflower oil supplementation on performance, immunoglobulin, and antioxidant vitamin status of rats. Biomed Res Int. 2014;2014:606575. doi: 10.1155/2014/606575. Epub 2014 Jul 16.
  • PMID: 18715434
    Osman H, Usta IM, Rubeiz N, Abu-Rustum R, Charara I, Nassar AH: Cocoa butter lotion for prevention of striae gravidarum: a double-blind, randomised and placebo-controlled trial. BJOG. 2008 Aug;115(9):1138-42. doi: 10.1111/j.1471-0528.2008.01796.x.
  • PMID: 25116848
    Scapagnini G, Davinelli S, Di Renzo L, De Lorenzo A, Olarte HH, Micali G, Cicero AF, Gonzalez S: Cocoa bioactive compounds: significance and potential for the maintenance of skin health. Nutrients. 2014 Aug 11;6(8):3202-13. doi: 10.3390/nu6083202.
  • PMID: 16390538
    Ding EL, Hutfless SM, Ding X, Girotra S: Chocolate and prevention of cardiovascular disease: a systematic review. Nutr Metab (Lond). 2006 Jan 3;3:2. doi: 10.1186/1743-7075-3-2.
  • PMID: 12589329
    Steinberg FM, Bearden MM, Keen CL: Cocoa and chocolate flavonoids: implications for cardiovascular health. J Am Diet Assoc. 2003 Feb;103(2):215-23. doi: 10.1053/jada.2003.50028.
  • PMID: 18830150
    Jalil AM, Ismail A: Polyphenols in cocoa and cocoa products: is there a link between antioxidant properties and health? Molecules. 2008 Sep 16;13(9):2190-219.
  • PMID: 28649251
    Magrone T, Russo MA, Jirillo E: Cocoa and Dark Chocolate Polyphenols: From Biology to Clinical Applications. Front Immunol. 2017 Jun 9;8:677. doi: 10.3389/fimmu.2017.00677. eCollection 2017.

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Sekuens Gen/Protein (FASTA)

Sekuens dimuat saat dibutuhkan agar halaman tetap ringan.
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