Peringatan Keamanan

Effects in man include CNS effects, mainly in persons who have used creams containing high levels of resorcinol, effects on the erythrocytes (especially methaemoglobinaemia, mainly in babies and infants) and, after prolonged exposure, effects on the thyroid gland (like goiter or especially chronic myxoedema) F61. In addition, exogenous ochronosis is associated with prolonged exposure to resorcinol F61. In persons suffering from resorcinol poisoning, the symptoms included anemia, spleen siderosis, and fatty degeneration of the liver and kidneys F61.

Resorcinol

DB11085

small molecule approved

Deskripsi

Resorcinol is a 1,3-isomer (or meta-isomer) of benzenediol with the formula C6H4(OH)2. It is used as an antiseptic and disinfectant in topical pharmaceutical products in the treatment of skin disorders and infections such as acne, seborrheic dermatitis, eczema, psoriasis, corns, calluses, and warts. It exerts a keratolytic activity. Resorcinol works by helping to remove hard, scaly, or roughened skin.

Although it is primarily indicated for use as a topical application, resorcinol also possesses a well-documented anti-thyroidal activity that is generally not relied upon for any kind of formal therapeutic indication.

Struktur Molekul 2D

Berat 110.1106
Wujud -

Peta Jejaring Molekuler
Legenda: ObatTargetGenEnzim(Panah → menunjukkan arah efek / relasi)TransporterCarrier

Profil Farmakokinetik

Waktu Paruh (Half-Life) Specific data regarding the half-life of resorcinol is not readily available, although, in one case of dermal exposure, an adult male with a 90% phenol exposure had an elimination half-life of about 14 hours [L2744].
Volume Distribusi Specific data regarding the volume of distribution of resorcinol is not readily available, although it is believed that the compound's volume of distribution is considered large, owing to resorcinol's profile as a lipid-soluble compound [L2744].
Klirens (Clearance) Specific data regarding the clearance of resorcinol is not readily available, although it is generally believed that the relatively low topical absorption or resorcinol does not result in an extensive systemic presence and clearance [F62, L2744].

Absorpsi

The dermal absorption of resorcinol seems to be low (< 1%) when applied on healthy and intact skin F62. The agent absorbed very slightly under normal conditions & the absorption was lower when applied to the scalp than to clean shaven skin due to a strong fixation by the hair L2744.

Metabolisme

Specific data regarding the metabolism of resorcinol is not readily available, although the major metabolite of resorcinol found in the urine was its glucuronide L2744.

Rute Eliminasi

Specific data regarding the route of elimination of resorcinol is not readily available, although the major metabolite of resorcinol found in the urine was its glucuronide L2744.

Interaksi Obat

748 Data
Cyclosporine Cyclosporine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Icosapent Icosapent may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefotiam Cefotiam may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Mesalazine Mesalazine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefmenoxime Cefmenoxime may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefmetazole Cefmetazole may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Pamidronic acid Pamidronic acid may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Tenofovir disoproxil Tenofovir disoproxil may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Indomethacin Indomethacin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cidofovir Cidofovir may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefpiramide Cefpiramide may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ceftazidime Ceftazidime may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Loracarbef Loracarbef may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefalotin Cefalotin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Nabumetone Nabumetone may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ketorolac Ketorolac may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Tenoxicam Tenoxicam may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Celecoxib Celecoxib may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefotaxime Cefotaxime may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Tolmetin Tolmetin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Foscarnet Foscarnet may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Rofecoxib Rofecoxib may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Piroxicam Piroxicam may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Methotrexate Methotrexate may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cephalexin Cephalexin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Fenoprofen Fenoprofen may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Valaciclovir Valaciclovir may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Valdecoxib Valdecoxib may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Diclofenac Diclofenac may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Sulindac Sulindac may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Bacitracin Bacitracin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Amphotericin B Amphotericin B may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cephaloglycin Cephaloglycin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Flurbiprofen Flurbiprofen may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Adefovir dipivoxil Adefovir dipivoxil may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Pentamidine Pentamidine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Etodolac Etodolac may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Mefenamic acid Mefenamic acid may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Acyclovir Acyclovir may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Naproxen Naproxen may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Sulfasalazine Sulfasalazine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Phenylbutazone Phenylbutazone may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Meloxicam Meloxicam may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Carprofen Carprofen may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefaclor Cefaclor may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Diflunisal Diflunisal may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Tacrolimus Tacrolimus may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ceforanide Ceforanide may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Salicylic acid Salicylic acid may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Meclofenamic acid Meclofenamic acid may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Acetylsalicylic acid Acetylsalicylic acid may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Carboplatin Carboplatin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Oxaprozin Oxaprozin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ketoprofen Ketoprofen may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Balsalazide Balsalazide may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ibuprofen Ibuprofen may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefditoren Cefditoren may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Atazanavir Atazanavir may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Colistimethate Colistimethate may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefuroxime Cefuroxime may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefapirin Cefapirin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefadroxil Cefadroxil may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefprozil Cefprozil may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ceftriaxone Ceftriaxone may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Olsalazine Olsalazine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Lumiracoxib Lumiracoxib may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefamandole Cefamandole may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefazolin Cefazolin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefonicid Cefonicid may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefoperazone Cefoperazone may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefotetan Cefotetan may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefoxitin Cefoxitin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ceftizoxime Ceftizoxime may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefradine Cefradine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Magnesium salicylate Magnesium salicylate may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Salsalate Salsalate may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Choline magnesium trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefepime Cefepime may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefacetrile Cefacetrile may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ceftibuten Ceftibuten may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cefpodoxime Cefpodoxime may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Antrafenine Antrafenine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Aminophenazone Aminophenazone may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Antipyrine Antipyrine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Phenazopyridine Phenazopyridine may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Tiaprofenic acid Tiaprofenic acid may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Lopinavir Lopinavir may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Etoricoxib Etoricoxib may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Hydrolyzed Cephalothin Hydrolyzed Cephalothin may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cephalothin Group Cephalothin Group may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Oxyphenbutazone Oxyphenbutazone may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Latamoxef Latamoxef may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Nimesulide Nimesulide may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Benoxaprofen Benoxaprofen may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Metamizole Metamizole may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Zomepirac Zomepirac may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ceftobiprole Ceftobiprole may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Cimicoxib Cimicoxib may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Ceftaroline fosamil Ceftaroline fosamil may decrease the excretion rate of Resorcinol which could result in a higher serum level.
Lornoxicam Lornoxicam may decrease the excretion rate of Resorcinol which could result in a higher serum level.

Target Protein

Carbonic anhydrase 12 CA12
Carbonic anhydrase 2 CA2
Carbonic anhydrase 14 CA14
Prostaglandin G/H synthase 1 PTGS1
Thyroid peroxidase TPO

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